Gene
tia1
- ID
- ZDB-GENE-030131-1506
- Name
- TIA1 cytotoxic granule-associated RNA binding protein
- Symbol
- tia1 Nomenclature History
- Previous Names
-
- fb73d10
- wu:fb73d10
- wu:fc02b04
- zgc:55520
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables mRNA 3'-UTR binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in cytoplasmic stress granule and nuclear stress granule. Is expressed in brain; retina; retinal ganglion cell layer; retinal inner nuclear layer; and trunk. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55520 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 26 | Alliance | Amyotrophic lateral sclerosis 26 with or without frontotemporal dementia | 619133 |
| Welander distal myopathy | 604454 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR003954 | RNA recognition motif domain, eukaryotes |
| Domain | IPR034827 | TIA-1, RNA recognition motif 1 |
| Domain | IPR034830 | TIA-1, RNA recognition motif 2 |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain | RNA recognition motif domain, eukaryotes | TIA-1, RNA recognition motif 1 | TIA-1, RNA recognition motif 2 |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3ASR4 | InterPro | 256 | ||||||
| UniProtKB:Q7ZVY0 | InterPro | 386 | ||||||
| UniProtKB:A0A8M3AZZ3 | InterPro | 385 |
Interactions and Pathways
No data available
Plasmids
No data available