Gene
rpl3
- ID
- ZDB-GENE-030131-1291
- Name
- ribosomal protein L3
- Symbol
- rpl3 Nomenclature History
- Previous Names
-
- wu:fa99g02
- wu:fb65e09
- zgc:110350
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Acts upstream of or within exocrine pancreas development. Predicted to be located in cytoplasm; nucleolus; and ribosome. Predicted to be part of cytosolic large ribosomal subunit. Is expressed in eye; liver; and pancreas. Used to study Shwachman-Diamond syndrome. Orthologous to human RPL3 (ribosomal protein L3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110350 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
Shwachman-Diamond syndrome | rpl3hi2437Tg/+; jh1Tg; jh2Tg | standard conditions | Provost et al., 2012 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR019926 | Large ribosomal subunit protein uL3, conserved site |
Family | IPR000597 | Large ribosomal subunit protein uL3 |
Family | IPR045077 | Large ribosomal subunit protein uL3, archaeal/eukaryotic-type |
Homologous_superfamily | IPR009000 | Translation protein, beta-barrel domain superfamily |
Homologous_superfamily | IPR044892 | Ribosomal protein L3, domain 3, archaeal-type superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Large ribosomal subunit protein uL3 | Large ribosomal subunit protein uL3, archaeal/eukaryotic-type | Large ribosomal subunit protein uL3, conserved site | Ribosomal protein L3, domain 3, archaeal-type superfamily | Translation protein, beta-barrel domain superfamily |
---|---|---|---|---|---|---|---|
UniProtKB:Q6Q418 | InterPro | 403 | |||||
UniProtKB:A0A2R8Q924 | InterPro PDB | 403 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-151M15 | ZFIN Curated Data | |
Encodes | EST | fa99g02 | ZFIN Curated Data | |
Encodes | EST | fb65e09 | ||
Encodes | cDNA | MGC:110350 | ZFIN Curated Data | |
Encodes | cDNA | MGC:191959 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001001590 (1) | 1371 nt | ||
Genomic | GenBank:BX901883 (1) | 241961 nt | ||
Polypeptide | UniProtKB:A0A2R8Q924 (1) | 403 aa |
- Li, Y.F., Cheng, T., Zhang, Y.J., Fu, X.X., Mo, J., Zhao, G.Q., Xue, M.G., Zhuo, D.H., Xing, Y.Y., Huang, Y., Sun, X.Z., Wang, D., Liu, X., Dong, Y., Zhu, X.S., He, F., Ma, J., Chen, D., Jin, X., Xu, P.F. (2022) Mycn regulates intestinal development through ribosomal biogenesis in a zebrafish model of Feingold syndrome 1. PLoS Biology. 20:e3001856
- Maffioli, E., Angiulli, E., Nonnis, S., Grassi Scalvini, F., Negri, A., Tedeschi, G., Arisi, I., Frabetti, F., D'Aniello, S., Alleva, E., Cioni, C., Toni, M. (2022) Brain Proteome and Behavioural Analysis in Wild Type, BDNF+/- and BDNF-/- Adult Zebrafish (Danio rerio) Exposed to Two Different Temperatures. International Journal of Molecular Sciences. 23(10)
- Madakashira, B.P., Zhang, C., Macchi, F., Magnani, E., Sadler, K.C. (2021) Nuclear Organization during Hepatogenesis in Zebrafish Requires Uhrf1. Genes. 12(7):
- Martín, M., Modenutti, C.P., Gil Rosas, M.L., Peyret, V., Geysels, R.C., Bernal Barquero, C.E., Sobrero, G., Muñoz, L., Signorino, M., Testa, G., Miras, M.B., Masini-Repiso, A.M., Calcaterra, N.B., Coux, G., Carrasco, N., Martí, M.A., Nicola, J.P. (2021) A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis. The Journal of clinical endocrinology and metabolism. 106(7):1867-1881
- Athanasiadis, E.I., Botthof, J.G., Andres, H., Ferreira, L., Lio, P., Cvejic, A. (2017) Single-cell RNA-sequencing uncovers transcriptional states and fate decisions in haematopoiesis. Nature communications. 8:2045
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Veerkamp, J., Rudolph, F., Cseresnyes, Z., Priller, F., Otten, C., Renz, M., Schaefer, L., and Abdelilah-Seyfried, S. (2013) Unilateral dampening of bmp activity by nodal generates cardiac left-right asymmetry. Developmental Cell. 24(6):660-667
- Zheng, W., Xu, H., Lam, S.H., Luo, H., Karuturi, R.K., and Gong, Z. (2013) Transcriptomic analyses of sexual dimorphism of the zebrafish liver and the effect of sex hormones. PLoS One. 8(1):e53562
- Provost, E., Wehner, K.A., Zhong, X., Ashar, F., Nguyen, E., Green, R., Parsons, M.J., and Leach, S.D. (2012) Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development. Development (Cambridge, England). 139(17):3232-3241
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