Gene
dnajc3a
- ID
- ZDB-GENE-030131-1264
- Name
- DnaJ (Hsp40) homolog, subfamily C, member 3a
- Symbol
- dnajc3a Nomenclature History
- Previous Names
-
- dnajc3
- wu:fb64f06
- zgc:77731
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable misfolded protein binding activity and protein-folding chaperone binding activity. Predicted to be involved in protein folding in endoplasmic reticulum. Predicted to act upstream of or within response to unfolded protein. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including axis; digestive system; hatching gland; periderm; and polster. Orthologous to human DNAJC3 (DnaJ heat shock protein family (Hsp40) member C3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56356 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la026884Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa16813 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa34665 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus | 616192 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001623 | DnaJ domain |
Family | IPR051727 | DnaJ Homolog Subfamily C Member 3 Co-Chaperones |
Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
Homologous_superfamily | IPR036869 | Chaperone J-domain superfamily |
Repeat | IPR019734 | Tetratricopeptide repeat |
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Domain Details Per Protein
Protein | Additional Resources | Length | Chaperone J-domain superfamily | DnaJ domain | DnaJ Homolog Subfamily C Member 3 Co-Chaperones | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat |
---|---|---|---|---|---|---|---|
UniProtKB:Q6P0U6 | InterPro | 504 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
dnajc3a-201
(1)
|
Ensembl | 1,934 nt | ||
ncRNA |
dnajc3a-002
(1)
|
Ensembl | 658 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-46K9 | ZFIN Curated Data | |
Encodes | cDNA | MGC:56356 | ZFIN Curated Data | |
Encodes | cDNA | MGC:77731 | ZFIN Curated Data | |
Has Artifact | EST | fb64f06 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_199610 (1) | 1923 nt | ||
Genomic | GenBank:BX537139 (1) | 243063 nt | ||
Polypeptide | UniProtKB:Q6P0U6 (1) | 504 aa |
- Li, X., Zhou, L., Zheng, Y., He, T., Guo, H., Li, J., Zhang, J. (2023) Establishment of a non-alcoholic fatty liver disease model by high fat diet in adult zebrafish. Animal models and experimental medicine. 7(6):904-913
- Park, K.H., Makki, H.M.M., Kim, S.H., Chung, H.J., Jung, J. (2023) Narirutin ameliorates alcohol-induced liver injury by targeting MAPK14 in zebrafish larvae. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 166:115350115350
- Elbialy, A., Sulidan, K., Bhuiyan, A., Igarashi, Y., Yoshitake, K., Yamanouchi, D., Kang, J., Asakawa, S., Watabe, S., Kinoshita, S. (2022) Induction of endoplasmic reticulum stress markers in an acromegaly model. Journal of cellular biochemistry. 123(9):1411-1421
- Ellis, J.L., Evason, K.J., Zhang, C., Fourman, M.N., Liu, J., Ninov, N., Delous, M., Vanhollebeke, B., Fiddes, I., Otis, J.P., Houvras, Y., Farber, S.A., Xu, X., Lin, X., Stainier, D.Y.R., Yin, C. (2022) A missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish. Hepatology communications. 6(11):3083-3097
- Singh, M.K., Jayarajan, R., Varshney, S., Upadrasta, S., Singh, A., Yadav, R., Scaria, V., Sengupta, S., Shanmugam, D., Shalimar, ., Sivasubbu, S., Gandotra, S., Sachidanandan, C. (2021) Chronic systemic exposure to IL6 leads to deregulation of glycolysis and fat accumulation in the zebrafish liver. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1866(5):158905
- Zhang, L., Kim, S.H., Park, K.H., Townsend, D., Tew, K.D. (2021) Glutathione S-Transferase P Influences Redox Homeostasis and Response to Drugs that Induce the Unfolded Protein Response in Zebrafish. The Journal of pharmacology and experimental therapeutics. 377(1):121-132
- Yang, B., Maddison, L.A., Zaborska, K.E., Dai, C., Yin, L., Tang, Z., Zang, L., Jacobson, D.A., Powers, A.C., Chen, W. (2020) RIPK3-mediated inflammation is a conserved β cell response to ER stress. Science advances. 6(51):
- Espenschied, S.T., Cronan, M.R., Matty, M.A., Mueller, O., Redinbo, M.R., Tobin, D.M., Rawls, J.F. (2019) Epithelial delamination is protective during pharmaceutical-induced enteropathy. Proceedings of the National Academy of Sciences of the United States of America. 116(34):16961-16970
- Park, K.H., Kim, S.H. (2019) Low dose of chronic ethanol exposure in adult zebrafish induces hepatic steatosis and injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 117:109179
- Park, K.H., Ye, Z.W., Zhang, J., Hammad, S.M., Townsend, D.M., Rockey, D.C., Kim, S.H. (2019) 3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish. Scientific Reports. 9:1138
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