Gene
slc2a2
- ID
- ZDB-GENE-030131-1213
- Name
- solute carrier family 2 member 2
- Symbol
- slc2a2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables D-glucose transmembrane transporter activity. Acts upstream of or within D-glucose import; brain development; and liver development. Predicted to be located in membrane. Predicted to be active in brush border and plasma membrane. Is expressed in several structures, including digestive system; muscle; nervous system; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Fanconi-Bickel syndrome; glycogen storage disease; and type 2 diabetes mellitus. Orthologous to human SLC2A2 (solute carrier family 2 member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Marín-Juez et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb719 | Allele with one delins | Exon 4 | Unknown | CRISPR | |
| ihb720 | Allele with one deletion | Exon 4 | Unknown | CRISPR | |
| la010638Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| zf4082 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| zf4083 | Allele with one deletion | Exon 3 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-slc2a2 | Zebrafish Nomenclature Committee | |
| MO1-slc2a2 | N/A | (2) |
| MO2-slc2a2 | N/A | Liu et al., 2013 |
| MO3-slc2a2 | N/A | Marín-Juez et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fanconi-Bickel syndrome | Alliance | Fanconi-Bickel syndrome | 227810 |
| type 2 diabetes mellitus | Alliance | {Diabetes mellitus, noninsulin-dependent} | 125853 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Glucose transporter GLUT | Major facilitator, sugar transporter-like | Major facilitator superfamily domain | MFS transporter superfamily | Sugar/inositol transporter | Sugar transporter, conserved site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q102R8 | InterPro | 504 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc2a2-201
(1)
|
Ensembl | 2,792 nt | ||
| ncRNA |
slc2a2-002
(1)
|
Ensembl | 829 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-153N9 | ZFIN Curated Data | |
| Encodes | EST | fb62h10 | ||
| Encodes | EST | IMAGE:7076647 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001042721 (1) | 2722 nt | ||
| Genomic | GenBank:CR392026 (2) | 191490 nt | ||
| Polypeptide | UniProtKB:Q102R8 (1) | 504 aa |
- Chen, J., Zhao, W., Cao, L., Martins, R.S.T., Canário, A.V.M. (2024) Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish. BMC Biology. 22:163163
- Ribeiro, T., Reis, M., Vasconcelos, V., Urbatzka, R. (2024) Phenotypic screening in zebrafish larvae identifies promising cyanobacterial strains and pheophorbide a as insulin mimetics. Scientific Reports. 14:3214232142
- Schmitner, N., Thumer, S., Regele, D., Mayer, E., Bergerweiss, I., Helker, C., Stainier, D.Y.R., Meyer, D., Kimmel, R.A. (2024) Conserved glucokinase regulation in zebrafish confirms therapeutic utility for pharmacologic modulation in diabetes. Communications biology. 7:15571557
- Wang, J.X., Zhang, Y.Y., Qian, Y.C., Qian, Y.F., Jin, A.H., Wang, M., Luo, Y., Qiao, F., Zhang, M.L., Chen, L.Q., Du, Z.Y. (2024) Inhibition of mitochondrial citrate shuttle alleviates metabolic syndromes induced by high-fat diet. American journal of physiology. Cell physiology. 327(3):C737-C749
- Zhu, X., Zhang, D., Wang, Y., Wang, C., Liu, X., Niu, Y. (2024) Study on the signaling pathways involved in the anti-hyperglycemic effect of raspberry ketone on zebrafish using integrative transcriptome and metabolome analyses. Food & function. 15(18):9457-9470
- Antomagesh, F., Jayakumar Rajeswari, J., Vijayan, M.M. (2023) Chronic cortisol elevation restricts glucose uptake but not insulin responsiveness in zebrafish skeletal muscle. General and comparative endocrinology. 336:114231
- Diogo, P., Martins, G., Simão, M., Marreiros, A., Eufrásio, A.C., Cabrita, E., Gavaia, P.J. (2023) Type I Diabetes in Zebrafish Reduces Sperm Quality and Increases Insulin and Glucose Transporter Transcripts. International Journal of Molecular Sciences. 24(8):
- Liu, R., Lu, Y., Peng, X., Jia, J., Ruan, Y., Shi, S., Shu, T., Li, T., Jin, X., Zhai, G., He, J., Lou, Q., Yin, Z. (2023) Enhanced insulin activity achieved in VDRa/b ablation zebrafish. Frontiers in endocrinology. 14:10546651054665
- Qian, X., Klatt, S., Bennewitz, K., Wohlfart, D.P., Lou, B., Meng, Y., Buettner, M., Poschet, G., Morgenstern, J., Fleming, T., Sticht, C., Hausser, I., Fleming, I., Szendroedi, J., Nawroth, P.P., Kroll, J. (2023) Impaired Detoxification of Trans, Trans-2,4-Decadienal, an Oxidation Product from Omega-6 Fatty Acids, Alters Insulin Signaling, Gluconeogenesis and Promotes Microvascular Disease. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 11(4):e2302325
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) Deciphering the pathogenesis of retinopathy associated with carnitine palmitoyltransferase I deficiency in zebrafish model. Biochemical and Biophysical Research Communications. 664:100107100-107
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