Gene
anxa2b
- ID
- ZDB-GENE-030131-1089
- Name
- annexin A2b
- Symbol
- anxa2b Nomenclature History
- Previous Names
-
- wu:fb59b10
- zgc:92492 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable calcium-dependent phospholipid binding activity and phosphatidylserine binding activity. Predicted to be involved in cell adhesion. Predicted to be located in basement membrane and extracellular region. Predicted to be active in several cellular components, including nucleus; plasma membrane; and vesicle membrane. Is expressed in gut and intestine. Human ortholog(s) of this gene implicated in osteonecrosis. Orthologous to several human genes including ANXA2 (annexin A2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92492 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb586 | Allele with one deletion | Exon 5 | Unknown | CRISPR | |
| ihb599 | Allele with one deletion | Exon 5 | Unknown | CRISPR | |
| sa20962 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30887 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40910 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-anxa2b | Quoseena et al., 2020 | |
| CRISPR2-anxa2b | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Annexin | Annexin A2 | Annexin repeat | Annexin repeat, conserved site | Annexin superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A8E5G1 | InterPro | 338 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
anxa2b-201
(1)
|
Ensembl | 1,324 nt | ||
| mRNA |
anxa2b-202
(1)
|
Ensembl | 1,297 nt | ||
| ncRNA |
anxa2b-003
(1)
|
Ensembl | 313 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(anxa2b:RFP) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-182O15 | ZFIN Curated Data | |
| Encodes | EST | fb59b10 | ||
| Encodes | cDNA | MGC:92492 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:123147 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174369 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193789 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001105600 (1) | 1279 nt | ||
| Genomic | GenBank:BX927082 (1) | 157140 nt | ||
| Polypeptide | UniProtKB:A8E5G1 (1) | 338 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | ANXA2 | 15 | Amino acid sequence comparison (1) |
- Hu, Y., Luo, Z., Wang, M., Wu, Z., Liu, Y., Cheng, Z., Sun, Y., Xiong, J.W., Tong, X., Zhu, Z., Zhang, B. (2024) Prox1a promotes liver growth and differentiation by repressing cdx1b expression and intestinal fate transition in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 52(1):66-77
- Kolb, J., Tsata, V., John, N., Kim, K., Möckel, C., Rosso, G., Kurbel, V., Parmar, A., Sharma, G., Karandasheva, K., Abuhattum, S., Lyraki, O., Beck, T., Müller, P., Schlüßler, R., Frischknecht, R., Wehner, A., Krombholz, N., Steigenberger, B., Beis, D., Takeoka, A., Blümcke, I., Möllmert, S., Singh, K., Guck, J., Kobow, K., Wehner, D. (2023) Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Nature communications. 14:68146814
- Quoseena, M., Vuppaladadium, S., Hussain, S., Banu, S., Bharathi, S., Idris, M.M. (2020) Functional role of annexins in zebrafish caudal fin regeneration - A gene knockdown approach in regenerating tissue. Biochimie. 175:125-131
- Park, J., Levic, D.S., Sumigray, K.D., Bagwell, J., Eroglu, O., Block, C.L., Eroglu, C., Barry, R., Lickwar, C.R., Rawls, J.F., Watts, S.A., Lechler, T., Bagnat, M. (2019) Lysosome-Rich Enterocytes Mediate Protein Absorption in the Vertebrate Gut. Developmental Cell. 51(1):7-20.e6
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Saxena, S., Purushothaman, S., Meghah, V., Bhatti, B., Poruri, A., Meena Lakshmi, M.G., Sarath Babu, N., Murthy, C.L., Mandal, K.K., Kumar, A., Idris, M.M. (2016) Role of Annexin gene and its regulation during zebrafish caudal fin regeneration. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 24(3):551-9
- Zhao, X.X., Zhang, Y.B., Ni, P.L., Wu, Z.L., Yan, Y.C., Li, Y.P. (2016) Protein Arginine Methyltransferase 6 (Prmt6) Is Essential for Early Zebrafish Development through the Direct Suppression of gadd45αa Stress Sensor Gene. The Journal of biological chemistry. 291(1):402-12
- Marjoram, L., Alvers, A., Deerhake, M.E., Bagwell, J., Mankiewicz, J., Cocchiaro, J.L., Beerman, R.W., Willer, J., Sumigray, K.D., Katsanis, N., Tobin, D.M., Rawls, J.F., Goll, M.G., Bagnat, M. (2015) Epigenetic control of intestinal barrier function and inflammation in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 112(9):2770-5
- Thakur, P.C., Davison, J.M., Stuckenholz, C., Lu, L., and Bahary, N. (2014) Dysregulated phosphatidylinositol signaling promotes endoplasmic reticulum stress-mediated intestinal mucosal injury and inflammation in zebrafish. Disease models & mechanisms. 7(1):93-106
- Stuckenholz, C., Lu, L., Thakur, P.C., Choi, T.Y., Shin, D., and Bahary, N. (2013) Sfrp5 Modulates Both Wnt and BMP Signaling and Regulates Gastrointestinal Organogensis in the Zebrafish, Danio rerio. PLoS One. 8(4):e62470
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