Gene
ctsla
- ID
- ZDB-GENE-030131-106
- Name
- cathepsin La
- Symbol
- ctsla Nomenclature History
- Previous Names
-
- ctsl1a
- cb143 (1)
- hm:zeh1631
- ik:tdsubc_2d2
- ik:tdsubc_2f10
- sb:cb143
- tdsubc_2f10
- wu:fb70e06
- wu:fi15c08
- xx:tdsubc_2d2
- xx:tdsubc_2f10
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space and lysosome. Is expressed in blood; digestive system; gill; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSL (cathepsin L).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb143 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
Active_site | IPR025660 | Cysteine peptidase, histidine active site |
Active_site | IPR025661 | Cysteine peptidase, asparagine active site |
Domain | IPR000668 | Peptidase C1A, papain C-terminal |
Domain | IPR013201 | Cathepsin propeptide inhibitor domain (I29) |
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Domain Details Per Protein
Protein | Additional Resources | Length | Cathepsin propeptide inhibitor domain (I29) | Cysteine peptidase, asparagine active site | Cysteine peptidase, cysteine active site | Cysteine peptidase, histidine active site | Papain-like cysteine endopeptidase | Papain-like cysteine peptidase superfamily | Peptidase C1A | Peptidase C1A, papain C-terminal |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2BCJ2 | InterPro | 363 | ||||||||
UniProtKB:Q6NYR5 | InterPro | 337 | ||||||||
UniProtKB:A5WVL6 | InterPro | 337 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-250N8 | ZFIN Curated Data | |
Encodes | EST | cb143 | Thisse et al., 2001 | |
Encodes | EST | fb70e06 | ||
Encodes | EST | fi15c08 | ||
Encodes | EST | tdsubc_2d2 | ||
Encodes | EST | tdsubc_2f10 | ||
Encodes | EST | zeh1631 | ||
Encodes | cDNA | MGC:76945 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_212584 (1) | 1426 nt | ||
Genomic | GenBank:CT025745 (2) | 77308 nt | ||
Polypeptide | UniProtKB:A0A8M2BCJ2 (1) | 363 aa |
- Lee, J.J., Wang, T., Wiggins, K., Lu, P.N., Underwood, C., Ochenkowska, K., Samarut, E., Pollard, L.M., Flanagan-Steet, H., Steet, R. (2024) Dysregulated lysosomal exocytosis drives protease-mediated cartilage pathogenesis in multiple lysosomal disorders. iScience. 27:109293109293
- Kolb, J., Tsata, V., John, N., Kim, K., Möckel, C., Rosso, G., Kurbel, V., Parmar, A., Sharma, G., Karandasheva, K., Abuhattum, S., Lyraki, O., Beck, T., Müller, P., Schlüßler, R., Frischknecht, R., Wehner, A., Krombholz, N., Steigenberger, B., Beis, D., Takeoka, A., Blümcke, I., Möllmert, S., Singh, K., Guck, J., Kobow, K., Wehner, D. (2023) Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Nature communications. 14:68146814
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595
- Casey, M.A., Hill, J.T., Hoshijima, K., Bryan, C.D., Gribble, S.L., Brown, J.T., Chien, C.B., Yost, H.J., Kwan, K.M. (2021) Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish. G3 (Bethesda). 12(3):
- Cavone, L., McCann, T., Drake, L.K., Aguzzi, E.A., Oprişoreanu, A.M., Pedersen, E., Sandi, S., Selvarajah, J., Tsarouchas, T.M., Wehner, D., Keatinge, M., Mysiak, K.S., Henderson, B.E.P., Dobie, R., Henderson, N.C., Becker, T., Becker, C.G. (2021) A unique macrophage subpopulation signals directly to progenitor cells to promote regenerative neurogenesis in the zebrafish spinal cord. Developmental Cell. 56(11):1617-1630.e6
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Han, B., Luo, J., Jiang, P., Li, Y., Wang, Q., Bai, Y., Chen, J., Wang, J., Zhang, J. (2020) Inhibition of Embryonic HSP 90 Function Promotes Variation of Cold Tolerance in Zebrafish. Frontiers in genetics. 11:541944
- King, A.C., Gut, M., Zenker, A.K. (2020) Shedding new light on early sex determination in zebrafish. Archives of toxicology. 94(12):4143-4158
- Lee, H.J., Hou, Y., Chen, Y., Dailey, Z.Z., Riddihough, A., Jang, H.S., Wang, T., Johnson, S.L. (2020) Regenerating zebrafish fin epigenome is characterized by stable lineage-specific DNA methylation and dynamic chromatin accessibility. Genome biology. 21:52
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