Gene

ctsla

ID
ZDB-GENE-030131-106
Name
cathepsin La
Symbol
ctsla Nomenclature History
Previous Names
  • ctsl1a
  • cb143 (1)
  • hm:zeh1631
  • ik:tdsubc_2d2
  • ik:tdsubc_2f10
  • sb:cb143
  • tdsubc_2f10
  • wu:fb70e06
  • wu:fi15c08
  • xx:tdsubc_2d2
  • xx:tdsubc_2f10
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space and lysosome. Is expressed in blood; digestive system; gill; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSL (cathepsin L).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa6998Allele with one point mutationUnknownPremature StopENU
sa20514Allele with one point mutationUnknownPremature StopENU
sa40539Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With ctsla Human Ortholog
No data available
Associated With ctsla Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR000169 Cysteine peptidase, cysteine active site
Active_site IPR025660 Cysteine peptidase, histidine active site
Active_site IPR025661 Cysteine peptidase, asparagine active site
Domain IPR000668 Peptidase C1A, papain C-terminal
Domain IPR013201 Cathepsin propeptide inhibitor domain (I29)
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Domain Details Per Protein
Protein Additional Resources Length Cathepsin propeptide inhibitor domain (I29) Cysteine peptidase, asparagine active site Cysteine peptidase, cysteine active site Cysteine peptidase, histidine active site Papain-like cysteine endopeptidase Papain-like cysteine peptidase superfamily Peptidase C1A Peptidase C1A, papain C-terminal
UniProtKB:A0A8M2BCJ2 InterPro 363
UniProtKB:Q6NYR5 InterPro 337
UniProtKB:A5WVL6 InterPro 337
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 5
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ctsla-201 (1) Ensembl 1,518 nt
mRNA ctsla-203 (1) Ensembl 768 nt
mRNA ctsla-204 (1) Ensembl 947 nt
mRNA ctsla-205 (1) Ensembl 1,390 nt
ncRNA ctsla-004 (1) Ensembl 878 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-250N8ZFIN Curated Data
EncodesESTcb143Thisse et al., 2001
EncodesESTfb70e06
EncodesESTfi15c08
EncodesESTtdsubc_2d2
EncodesESTtdsubc_2f10
EncodesESTzeh1631
EncodescDNAMGC:76945ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanCTSL9
Conserved genome location (synteny) (2)
Amino acid sequence comparison (1)
Citations
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