Gene
smc2
- ID
- ZDB-GENE-030131-105
- Name
- structural maintenance of chromosomes 2
- Symbol
- smc2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable chromatin binding activity. Acts upstream of or within DNA damage response and liver development. Predicted to be located in chromosome and nuclear lumen. Predicted to be part of condensin complex. Predicted to be active in chromatin and condensed chromosome. Is expressed in several structures, including blood vessel; digestive system; nervous system; optic vesicle; and pectoral fin. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human SMC2 (structural maintenance of chromosomes 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55326 (9 images)
- IMAGE:7165175 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Li et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa11094 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11231 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa13643 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU | |
| zf3797 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| zf3798 | Allele with one delins | Exon 1 | Unknown | CRISPR | |
| zko372a | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-smc2 | (2) | |
| CRISPR2-smc2 | Li et al., 2021 | |
| CRISPR3-smc2 | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003395 | RecF/RecN/SMC, N-terminal |
| Domain | IPR010935 | SMCs flexible hinge |
| Domain | IPR027120 | Smc2, ATP-binding cassette domain |
| Family | IPR024704 | Structural maintenance of chromosomes protein |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | P-loop containing nucleoside triphosphate hydrolase | RecF/RecN/SMC, N-terminal | Smc2, ATP-binding cassette domain | SMCs flexible hinge | SMCs flexible hinge superfamily | Structural maintenance of chromosomes protein |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:B8A5K9 | InterPro | 1199 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-245P14 | ZFIN Curated Data | |
| Contains | SNP | rs3727514 | ZFIN Curated Data | |
| Contains | SNP | rs3727515 | ZFIN Curated Data | |
| Contains | SNP | rs3727516 | ZFIN Curated Data | |
| Contains | SNP | rs3727517 | ZFIN Curated Data | |
| Contains | SNP | rs3727518 | ZFIN Curated Data | |
| Contains | SNP | rs3727519 | ZFIN Curated Data | |
| Contains | SNP | rs3727520 | ZFIN Curated Data | |
| Contains | SNP | rs3727521 | ZFIN Curated Data | |
| Contains | SNP | rs3727522 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199542 (1) | 4073 nt | ||
| Genomic | GenBank:BX548248 (1) | 195620 nt | ||
| Polypeptide | UniProtKB:B8A5K9 (1) | 1199 aa |
- Islam, K.N., Modi, M.M., Siegfried, K.R. (2021) The Zebrafish Meiotic Cohesin Complex Protein Smc1b Is Required for Key Events in Meiotic Prophase I. Frontiers in cell and developmental biology. 9:714245
- Li, X., Song, G., Zhao, Y., Ren, J., Li, Q., Cui, Z. (2021) Functions of SMC2 in the Development of Zebrafish Liver. Biomedicines. 9(9):
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Deng, C., Chen, H., Yang, N., Feng, Y., Hsueh, A.J. (2015) Apela regulates fluid homeostasis by binding to the APJ receptor to activate Gi signaling. The Journal of biological chemistry. 290(30):18261-8
- Mans, D.A., Vermaat, J.S., Weijts, B.G., van Rooijen, E., van Reeuwijk, J., Boldt, K., Daenen, L.G., van der Groep, P., Rowland, B.D., Jans, J.J., Roepman, R., Voest, E.E., van Diest, P.J., Verhaar, M.C., de Bruin, A., and Giles, R.H. (2013) Regulation of E2F1 by the von Hippel-Lindau tumour suppressor protein predicts survival in renal cell cancer patients. The Journal of pathology. 231(1):117-29
- Recher, G., Jouralet, J., Brombin, A., Heuzé, A., Mugniery, E., Hermel, J.M., Desnoulez, S., Savy, T., Herbomel, P., Bourrat, F., Peyriéras, N., Jamen, F., and Joly, J.S. (2013) Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Development (Cambridge, England). 140(24):4860-9
- Ma, D., Wang, L., Wang, S., Gao, Y., Wei, Y., and Liu, F. (2012) Foxn1 maintains thymic epithelial cells to support T-cell development via mcm2 in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 109(51):21040-21045
- Mönnich, M., Banks, S., Eccles, M., Dickinson, E., and Horsfield, J. (2009) Expression of cohesin and condensin genes during zebrafish development supports a non-proliferative role for cohesin. Gene expression patterns : GEP. 9(8):586-594
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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