Gene
esr2b
- ID
- ZDB-GENE-030116-1
- Name
- estrogen receptor 2b
- Symbol
- esr2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Enables estradiol binding activity; nuclear estrogen receptor activity; and steroid hormone binding activity. Involved in sex determination. Acts upstream of or within embryonic cranial skeleton morphogenesis; response to estrogen; and swimming behavior. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including forebrain; head; liver; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); bone disease (multiple); hypospadias; and neurodegenerative disease (multiple). Orthologous to human ESR2 (estrogen receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 25 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103724 (1 image)
- aj414566 (14 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa77 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| uab127 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
| uab128 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| ulg079 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | CRISPR | |
| umo13 | Allele with one deletion | Exon 1 | Premature Stop | CRISPR | |
| zf3760 | unknown | Unknown | Unknown | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-esr2b | (4) | |
| CRISPR2-esr2b | (4) | |
| CRISPR3-esr2b | (2) | |
| MO1-esr2b | N/A | (4) |
| MO2-esr2b | N/A | (6) |
| MO3-esr2b | N/A | Bugel et al., 2016 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ovarian dysgenesis 8 | Alliance | ?Ovarian dysgenesis 8 | 618187 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR021064 | Estrogen receptor beta-like, N-terminal |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR024178 | Estrogen receptor/oestrogen-related receptor |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Estrogen receptor beta/gamma | Estrogen receptor beta-like, N-terminal | Estrogen receptor/oestrogen-related receptor | Nuclear hormone receptor | Nuclear hormone receptor family NR3 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B359 | InterPro | 600 | |||||||||
| UniProtKB:Q5PR29 | InterPro | 592 | |||||||||
| UniProtKB:B8JJL3 | InterPro | 592 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(esr2b:EGFP) |
|
| 1 | Wang et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-249P9 | ZFIN Curated Data | |
| Encodes | EST | aj414566 | Bertrand et al., 2007 | |
| Encodes | cDNA | MGC:103724 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191967 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_174862 (1) | 2718 nt | ||
| Genomic | GenBank:CT025749 (1) | 188450 nt | ||
| Polypeptide | UniProtKB:A0A8M2B359 (1) | 600 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | ESR2 | 14 | Phylogenetic tree (1) Amino acid sequence comparison (4) Conserved genome location (synteny) (1) Nucleotide sequence comparison (1) | |
| Mouse | Esr2 | 12 | Amino acid sequence comparison (3) Conserved genome location (synteny) (1) Nucleotide sequence comparison (1) Phylogenetic tree (1) |
- Ai, N., Han, C.R., Zhao, H., Cheng, S.Y., Ge, W. (2024) Disruption of thyroid hormone receptor thrab leads to female infertility in zebrafish. Endocrinology. 165(5):
- Guerrero-Limón, G., Muller, M. (2024) Exploring Estrogen antagonism using CRISPR/Cas9 to generate specific mutants for each of the receptors. Chemosphere. 364:143100
- Peng, W., Zhang, Y., Song, B., Yang, P., Liu, L. (2024) Developmental Delay and Male-Biased Sex Ratio in esr2b Knockout Zebrafish. Genes. 15(5):
- Uju, C., Karimzadeh, K., Unniappan, S. (2024) Brain Derived Neurotrophic Factor Stimulates Hypothalamic and Gonadal Reproductive Hormones and Oocyte Maturation in Zebrafish. Reproduction (Cambridge, England). 169(1):
- Zadmajid, V., Shahriar, S., Gorelick, D.A. (2024) Testosterone acts through membrane protein GPRC6A to cause cardiac edema in zebrafish embryos. Development (Cambridge, England). 151(23):
- Zhang, F., Tang, C., Wang, J., Lin, T., Ge, W., He, C., Yang, C., Zuo, Z. (2024) Letrozole induced a polycystic ovary syndrome model in zebrafish by interfering with the hypothalamic-pituitary-gonadal axis. Environmental pollution (Barking, Essex : 1987). 347:123723
- Pellegrini, E., Fernezelian, D., Malleret, C., Gueguen, M.M., Patche-Firmin, J., Rastegar, S., Meilhac, O., Diotel, N. (2023) Estrogenic regulation of claudin 5 and tight junction protein 1 gene expression in zebrafish: A role on blood-brain barrier?. The Journal of comparative neurology. 531(17):1828-1845
- Shaw, K., Lu, C., Liu, X., Trudeau, V.L. (2023) Arginine vasopressin injection rescues delayed oviposition in cyp19a1b-/- mutant female zebrafish. Frontiers in endocrinology. 14:13086751308675
- Wesselman, H.M., Gatz, A.E., Pfaff, M.R., Arceri, L., Wingert, R.A. (2023) Estrogen Signaling Influences Nephron Segmentation of the Zebrafish Embryonic Kidney. Cells. 12(4):
- Zhai, Y., Zhang, X., Zhao, C., Geng, R., Wu, K., Yuan, M., Ai, N., Ge, W. (2023) Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis. PLoS Genetics. 19:e1010954e1010954
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