Gene
wdr43
- ID
- ZDB-GENE-021231-3
- Name
- WD repeat domain 43
- Symbol
- wdr43 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including blood vessel morphogenesis; embryonic viscerocranium morphogenesis; and hematopoietic stem cell differentiation. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in brain; gut epithelium; and pharyngeal arch. Orthologous to human WDR43 (WD repeat domain 43).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Zhao et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi821aTg | Transgenic insertion | Intron 2 | Unknown | DNA | |
| hi2144Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| sa23082 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa36414 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa36415 | Allele with one point mutation | Unknown | Unknown | ENU | |
| tft001 | Allele with one point mutation | Exon 9 | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR007148 | Small-subunit processome, Utp12 |
| Domain | IPR024977 | Anaphase-promoting complex subunit 4-like, WD40 domain |
| Family | IPR052414 | U3 small nucleolar RNA-associated WD repeat-containing protein |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Anaphase-promoting complex subunit 4-like, WD40 domain | Small-subunit processome, Utp12 | U3 small nucleolar RNA-associated WD repeat-containing protein | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q8JHG6 | InterPro | 650 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-195O20 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-74H17 | ZFIN Curated Data | |
| Encodes | EST | fb83h12 | ||
| Encodes | EST | fc13e01 | ||
| Encodes | cDNA | MGC:110501 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:172003 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174198 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193931 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193937 | ZFIN Curated Data | |
| Has Artifact | EST | fc27f04 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001018166 (1) | 2696 nt | ||
| Genomic | GenBank:CR391986 (1) | 131805 nt | ||
| Polypeptide | UniProtKB:Q8JHG6 (1) | 650 aa |
- Yan, F., Hao, Z., Zeng, J., Liu, Y., Dai, Q., Zhu, Y., Zhi, Z., Lin, H., Li, S., Chen, H., Zhang, Y. (2024) Identification of a neuropeptide in suppressing food intake in zebrafish. Biochemical and Biophysical Research Communications. 734:150752150752
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zhao, C., Andreeva, V., Gibert, Y., LaBonty, M., Lattanzi, V., Prabhudesai, S., Zhou, Y., Zon, L., McCann, K.L., Baserga, S., and Yelick, P.C. (2014) Tissue specific roles for the ribosome biogenesis factor Wdr43 in zebrafish development. PLoS Genetics. 10(1):e1004074
- Burns, C.E., Galloway, J.L., Smith, A.C., Keefe, M.D., Cashman, T.J., Paik, E.J., Mayhall, E.A., Amsterdam, A.H., and Zon, L.I. (2009) A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence. Blood. 113(23):5776-5782
- Parant, J.M., George, S.A., Pryor, R., Wittwer, C.T., and Yost, H.J. (2009) A rapid and efficient method of genotyping zebrafish mutants. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(12):3168-3174
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
- Golling, G., Amsterdam, A., Sun, Z., Antonelli, M., Maldonado, E., Chen, W., Burgess, S., Haldi, M., Artzt, K., Farrington, S., Lin, S.Y., Nissen, R.M., and Hopkins, N. (2002) Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development. Nature Genetics. 31(2):135-140
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
- Amsterdam, A., Burgess, S., Golling, G., Chen, W., Sun, Z., Townsend, K., Farrington, S., Haldi, M., and Hopkins, N. (1999) A large-scale insertional mutagenesis screen in zebrafish. Genes & Development. 13(20):2713-2724
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