Gene
lamb4
- ID
- ZDB-GENE-021226-2
- Name
- laminin, beta 4
- Symbol
- lamb4 Nomenclature History
- Previous Names
-
- fa05e06
- wu:fa05e06
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Involved in retina layer formation. Acts upstream of or within glial cell development and retina development in camera-type eye. Predicted to be located in basement membrane and extracellular region. Predicted to be part of laminin complex. Is expressed in several structures, including central nervous system; head; liver; median fin fold; and notochord. Orthologous to human LAMB4 (laminin subunit beta 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Charlton-Perkins et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la023303Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa6002 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa6808 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9508 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18559 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24711 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30287 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 7 of 7
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-lamb4 | Charlton-Perkins et al., 2019 | |
| CRISPR2-lamb4 | Charlton-Perkins et al., 2019 | |
| MO1-lamb4 | N/A | Parsons et al., 2002 |
1 - 3 of 3
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like domain | Laminin IV type B | Laminin/Netrin Extracellular Matrix | Laminin, N-terminal | Laminin-type EGF domain | Spectrin/alpha-actinin |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q8JHV6 | InterPro | 1827 | ||||||
| UniProtKB:A0AB32TIW6 | InterPro | 1827 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-380L19 | ZFIN Curated Data | |
| Encodes | EST | fa05e06 | Parsons et al., 2002 |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_173276 (1) | 6792 nt | ||
| Genomic | GenBank:CABZ01079202 (1) | 40679 nt | ||
| Polypeptide | UniProtKB:A0AB32TIW6 (1) | 1827 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | LAMB4 | 7 | Amino acid sequence comparison (2) |
- Hu, T., Liu, L., Wang, H., Yang, M., Xu, B., Xie, H., Lin, Z., Jin, X., Wang, P., Liu, Y., Sun, H., Liu, S. (2024) RCAN family member 3 deficiency contributes to noncompaction of the ventricular myocardium. Journal of genetics and genomics = Yi chuan xue bao. 51(5):543-553
- Zhao, N., Wang, X., Wang, T., Xu, X., Liu, Q., Li, J. (2022) Genome-Wide Identification of Laminin Family Related to Follicular Pseudoplacenta Development in Black Rockfish (Sebastes schlegelii). International Journal of Molecular Sciences. 23(18)
- Charlton-Perkins, M., Almeida, A.D., MacDonald, R.B., Harris, W.A. (2019) Genetic control of cellular morphogenesis in Müller glia. Glia. 67(7):1401-1411
- DeRossi, C., Bambino, K., Morrison, J., Sakarin, I., Villacorta-Martin, C., Zhang, C., Ellis, J.L., Fiel, M.I., Ybanez, M., Lee, Y.A., Huang, K.L., Yin, C., Sakaguchi, T.F., Friedman, S.L., Villanueva, A., Chu, J. (2019) Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans. Hepatology (Baltimore, Md.). 70(6):2107-2122
- Nicholas, C., Weaver, M., Piedade, W.P., Vocking, O., Famulski, J.K. (2019) Temporal characterization of optic fissure basement membrane composition suggests nidogen may be an initial target of remodeling. Developmental Biology. 452(1):43-54
- Chen, C.H., Merriman, A.F., Savage, J., Willer, J., Wahlig, T., Katsanis, N., Yin, V.P., Poss, K.D. (2015) Transient laminin beta 1a Induction Defines the Wound Epidermis during Zebrafish Fin Regeneration. PLoS Genetics. 11:e1005437
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Sztal, T., Berger, S., Currie, P.D., and Hall, T.E. (2011) Characterization of the laminin gene family and evolution in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(2):422-431
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
1 - 10 of 11
Show