Gene
lamb1a
- ID
- ZDB-GENE-021226-1
- Name
- laminin, beta 1a
- Symbol
- lamb1a Nomenclature History
- Previous Names
-
- lamb1
- cb95 (1)
- fc20b05
- grumpy
- gup
- sb:cb95
- wu:fc20b05
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Enables mechanoreceptor activity. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; determination of left/right asymmetry in lateral mesoderm; and nervous system development. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of laminin complex. Is expressed in several structures, including digestive system; eye; fin; heart; and optic cup. Used to study coloboma. Human ortholog(s) of this gene implicated in autistic disorder and lissencephaly 5. Orthologous to human LAMB1 (laminin subunit beta 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb95 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- 64 figures from 24 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi1113bTg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| hi1297Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| hi3181Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| lamb1a_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
| m135 | unknown | Unknown | Unknown | ENU | |
| m189 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| m217 | unknown | Unknown | Unknown | ENU | |
| m726 | unknown | Unknown | Unknown | ENU | |
| m753 | unknown | Unknown | Unknown | ENU | |
| pd110 | Allele with one point mutation | Unknown | Missense | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-lamb1a | Derrick et al., 2021 | |
| MO1-lamb1a | N/A | (4) |
| MO2-lamb1a | N/A | Hochgreb-Hägele et al., 2013 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| lissencephaly 5 | Alliance | Lissencephaly 5 | 615191 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| coloboma | lamb1am189/m189 | standard conditions | (2) |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like domain | Galactose-binding-like domain superfamily | Laminin IV type B | Laminin/Netrin Extracellular Matrix | Laminin, N-terminal | Laminin-type EGF domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q8JHV7 | InterPro | 1785 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lamb1a-201
(1)
|
Ensembl | 1,654 nt | ||
| mRNA |
lamb1a-202
(1)
|
Ensembl | 5,358 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-332D23 | ZFIN Curated Data | |
| Encodes | EST | cb95 | ||
| Encodes | EST | fc20b05 | Parsons et al., 2002 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_173275 (1) | 5358 nt | ||
| Genomic | GenBank:CU929267 (2) | 37889 nt | ||
| Polypeptide | UniProtKB:Q8JHV7 (1) | 1785 aa |
- Pollitt, E.J.G., Sánchez-Posada, J., Snashall, C.M., Derrick, C.J., Noël, E.S. (2024) Llgl1 mediates timely epicardial emergence and establishment of an apical laminin sheath around the trabeculating cardiac ventricle. Development (Cambridge, England). 151(13):
- Drepanos, L., Gans, I.M., Grendler, J., Guitar, S., Fuqua, J.H., Maki, N.J., Tilden, A.R., Graber, J.H., Coffman, J.A. (2023) Loss of Krüppel-like factor 9 deregulates both physiological gene expression and development. Scientific Reports. 13:1223912239
- Kolb, J., Tsata, V., John, N., Kim, K., Möckel, C., Rosso, G., Kurbel, V., Parmar, A., Sharma, G., Karandasheva, K., Abuhattum, S., Lyraki, O., Beck, T., Müller, P., Schlüßler, R., Frischknecht, R., Wehner, A., Krombholz, N., Steigenberger, B., Beis, D., Takeoka, A., Blümcke, I., Möllmert, S., Singh, K., Guck, J., Kobow, K., Wehner, D. (2023) Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Nature communications. 14:68146814
- Falat, E.J., Voit, G.C., Gutzman, J.H. (2022) Laminin-111 mutant studies reveal a hierarchy within laminin-111 genes in their requirement for basal epithelial tissue folding. Developmental Biology. 492:172-186
- Zhao, N., Wang, X., Wang, T., Xu, X., Liu, Q., Li, J. (2022) Genome-Wide Identification of Laminin Family Related to Follicular Pseudoplacenta Development in Black Rockfish (Sebastes schlegelii). International Journal of Molecular Sciences. 23(18)
- Derrick, C.J., Pollitt, E.J.G., Sevilla Uruchurtu, A.S., Hussein, F., Grierson, A.J., Noël, E.S. (2021) Lamb1a regulates atrial growth by limiting second heart field addition during zebrafish heart development. Development (Cambridge, England). 148(20)
- Roan, H.Y., Tseng, T.L., Chen, C.H. (2021) Whole-body clonal mapping identifies giant dominant clones in zebrafish skin epidermis. Development (Cambridge, England). 148(18)
- Tseng, T.L., Wang, Y.T., Tsao, C.Y., Ke, Y.T., Lee, Y.C., Hsu, H.J., Poss, K.D., Chen, C.H. (2021) The RNA helicase Ddx52 functions as a growth switch in juvenile zebrafish. Development (Cambridge, England). 148(15):
- Nicholas, C., Weaver, M., Piedade, W.P., Vocking, O., Famulski, J.K. (2019) Temporal characterization of optic fissure basement membrane composition suggests nidogen may be an initial target of remodeling. Developmental Biology. 452(1):43-54
- Wang, Y.T., Tseng, T.L., Kuo, Y.C., Yu, J.K., Su, Y.H., Poss, K.D., Chen, C.H. (2019) Genetic Reprogramming of Positional Memory in a Regenerating Appendage. Current biology : CB. 29(24):4193-4207.e4
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