Gene

lamb1a

ID
ZDB-GENE-021226-1
Name
laminin, beta 1a
Symbol
lamb1a Nomenclature History
Previous Names
  • lamb1
  • cb95 (1)
  • fc20b05
  • grumpy
  • gup
  • sb:cb95
  • wu:fc20b05
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Enables mechanoreceptor activity. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; determination of left/right asymmetry in lateral mesoderm; and nervous system development. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of laminin complex. Is expressed in several structures, including digestive system; eye; fin; heart; and optic cup. Used to study coloboma. Human ortholog(s) of this gene implicated in autistic disorder and lissencephaly 5. Orthologous to human LAMB1 (laminin subunit beta 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
20 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
64 figures from 24 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
hi1113bTgTransgenic insertionIntron 1UnknownDNA
hi1297TgTransgenic insertionIntron 1UnknownDNA
hi3181TgTransgenic insertionIntron 1UnknownDNA
lamb1a_unspecifiedUnspecified AlleleUnknownUnknownnot specified
m135unknownUnknownUnknownENU
m189Allele with one point mutationUnknownPremature StopENU
m217unknownUnknownUnknownENU
m726unknownUnknownUnknownENU
m753unknownUnknownUnknownENU
pd110Allele with one point mutationUnknownMissenseENU
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Sequence Targeting Reagents
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Human Disease
Associated With lamb1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
lissencephaly 5 Alliance Lissencephaly 5 615191
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Associated With lamb1a Via Experimental Models
Human Disease Fish Conditions Citations
coloboma lamb1am189/m189 standard conditions (2)
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Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000742 EGF-like domain
Domain IPR002049 Laminin-type EGF domain
Domain IPR008211 Laminin, N-terminal
Domain IPR013015 Laminin IV type B
Family IPR050440 Laminin/Netrin Extracellular Matrix
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Domain Details Per Protein
Protein Additional Resources Length EGF-like domain Galactose-binding-like domain superfamily Laminin IV type B Laminin/Netrin Extracellular Matrix Laminin, N-terminal Laminin-type EGF domain
UniProtKB:Q8JHV7 InterPro 1785
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 25
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA lamb1a-201 (1) Ensembl 1,654 nt
mRNA lamb1a-202 (1) Ensembl 5,358 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inFosmidCH1073-332D23ZFIN Curated Data
EncodesESTcb95
EncodesESTfc20b05Parsons et al., 2002
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanLAMB17
Nucleotide sequence comparison (1)
Amino acid sequence comparison (3)
MouseLamb112
Amino acid sequence comparison (1)
Citations
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