Gene
mc4r
- ID
- ZDB-GENE-021223-2
- Name
- melanocortin 4 receptor
- Symbol
- mc4r Nomenclature History
- Previous Names
-
- zMC4
- si:dkey-151m6.62
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables melanocortin receptor activity. Involved in energy homeostasis and energy reserve metabolic process. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of feeding behavior; and regulation of growth. Predicted to be located in membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in brain; female organism; gonad; myotome; and primary motor neurons. Human ortholog(s) of this gene implicated in morbid obesity and obesity. Orthologous to human MC4R (melanocortin 4 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Melanocortin 4 receptor | Melanocortin/ACTH receptor | Melanocortin receptor 3-5 |
|---|---|---|---|---|---|---|---|
| UniProtKB:B0V1P1 | InterPro | 326 |
Interactions and Pathways
No data available
Plasmids
No data available