Gene
mc4r
- ID
- ZDB-GENE-021223-2
- Name
- melanocortin 4 receptor
- Symbol
- mc4r Nomenclature History
- Previous Names
-
- zMC4
- si:dkey-151m6.62
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables melanocortin receptor activity. Involved in energy homeostasis and energy reserve metabolic process. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of feeding behavior; and regulation of growth. Predicted to be located in membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in brain; female organism; gonad; myotome; and primary motor neurons. Human ortholog(s) of this gene implicated in morbid obesity and obesity. Orthologous to human MC4R (melanocortin 4 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa122 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa148 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa149 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf3069 | Allele with one delins | Unknown | Unknown | CRISPR | |
| zf3584 | Allele with one insertion | Exon 1 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mc4r | Xie et al., 2016 | |
| CRISPR2-mc4r | (2) | |
| CRISPR3-mc4r | Mazzaferro et al., 2025 | |
| MO1-mc4r | N/A | (2) |
| MO2-mc4r | N/A | Shimada et al., 2012 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Melanocortin 4 receptor | Melanocortin/ACTH receptor | Melanocortin receptor 3-5 |
|---|---|---|---|---|---|---|---|
| UniProtKB:B0V1P1 | InterPro | 326 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-151M6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194184 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194203 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_173278 (1) | 981 nt | ||
| Genomic | GenBank:CR925777 (2) | 210659 nt | ||
| Polypeptide | UniProtKB:B0V1P1 (1) | 326 aa |
- Mazzaferro, E., Mujica, E., Zhang, H., Emmanouilidou, A., Jenseit, A., Evcimen, B., Metzendorf, C., Dethlefsen, O., Loos, R.J., Vienberg, S.G., Larsson, A., Allalou, A., den Hoed, M. (2025) Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning. Scientific Reports. 15:54085408
- Rajeswari, J.J., Faught, E., Santos, H., Vijayan, M.M. (2024) Mineralocorticoid receptor activates postnatal adiposity in zebrafish lacking proopiomelanocortin. Journal of Cellular Physiology. 239(12):e31428
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Navarro, S., Crespo, D., Schulz, R.W., Ge, W., Rotllant, J., Cerdá-Reverter, J.M., Rocha, A. (2022) Role of the Melanocortin System in Gonadal Steroidogenesis of Zebrafish. Animals : an open access journal from MDPI. 12(20):
- Nipu, N., Antomagesh, F., Faught, E., Vijayan, M.M. (2022) Glucocorticoid receptor activation reduces food intake independent of hyperglycemia in zebrafish. Scientific Reports. 12:15677
- Xu, J., Wang, M., Fu, Y., Zhang, C., Kuang, Z., Bian, S., Wan, R., Qu, S., Zhang, C. (2022) Reversion of MRAP2 Protein Sequence Generates a Functional Novel Pharmacological Modulator for MC4R Signaling. Biology. 11(6)
- Del Vecchio, G., Murashita, K., Verri, T., Gomes, A.S., Rønnestad, I. (2021) Leptin receptor-deficient (knockout) zebrafish: effects on nutrient acquisition. General and comparative endocrinology. 310:113832
- Li, Z., Jiang, B., Cao, B., Zhang, Z., Zhang, J., Li, J., Huang, Y., Wang, Y. (2021) Characterization of Four Orphan Receptors (GPR3, GPR6, GPR12 and GPR12L) in Chickens and Ducks and Regulation of GPR12 Expression in Ovarian Granulosa Cells by Progesterone. Genes. 12(4):
- Schneider, A.C.R., de Moura, A.C., Carvalho, F.B., Alves, T., Meurer, F., Porawski, M., da Silveira, T.R. (2021) Effect of Melatonin on the Reduction of Hepatic Steatosis and Intestinal Leptin Expression in Zebrafish Exposed to Fructose. Zebrafish. 18(3):184-189
- Fei, F., Sun, S., Li, Q., Pei, Z., Wang, L., Zhang, R., Luo, F., Yu, M., Wang, X. (2020) Combinatorial normalization of liver-derived cytokine pathways alleviates hepatic tumor-associated cachexia in zebrafish. Cancer research. 81(4):873-884
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