Gene
f7i
- ID
- ZDB-GENE-021206-10
- Name
- coagulation factor VIIi
- Symbol
- f7i Nomenclature History
- Previous Names
-
- factor VII-like gene
- fb61d02
- wu:fb61d02 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase activity. Acts upstream of or within negative regulation of blood coagulation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebral infarction; diabetes mellitus (multiple); factor VII deficiency; and obesity. Orthologous to human F7 (coagulation factor VII).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la028149Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa19389 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 2 of 2
Show
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-f7i | Sun et al., 2019 | |
CRISPR2-f7i | Sun et al., 2019 | |
MO1-f7i | N/A | Gregory et al., 2002 |
1 - 3 of 3
Show
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR018114 | Serine proteases, trypsin family, histidine active site |
Domain | IPR000294 | Gamma-carboxyglutamic acid-rich (GLA) domain |
Domain | IPR000742 | EGF-like domain |
Domain | IPR001254 | Serine proteases, trypsin domain |
Domain | IPR001881 | EGF-like calcium-binding domain |
1 - 5 of 12 Show all
Domain Details Per Protein
Protein | Additional Resources | Length | Coagulation factor-like, Gla domain superfamily | EGF-like calcium-binding domain | EGF-like domain | Gamma-carboxyglutamic acid-rich (GLA) domain | Gamma-carboxyglutamic acid-rich (GLA) domain superfamily | Peptidase S1A, chymotrypsin family | Peptidase S1A, coagulation factor VII/IX/X/C/Z | Peptidase S1 family, coagulation factors | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Serine proteases, trypsin domain | Serine proteases, trypsin family, histidine active site |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:F1QPL4 | InterPro | 443 | ||||||||||||
UniProtKB:F1QZK5 | InterPro | |||||||||||||
UniProtKB:Q8JHC9 | InterPro | 443 | ||||||||||||
UniProtKB:A0A8N7UZT1 | InterPro | 443 |
1 - 4 of 4
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-367P20 | ZFIN Curated Data | |
Contained in | Fosmid | ZFOS-1608A7 | ZFIN Curated Data | |
Contained in | Fosmid | ZFOS-1962A1 | ZFIN Curated Data | |
Encodes | EST | fb61d02 | ZFIN Curated Data | |
Encodes | cDNA | MGC:136351 | ZFIN Curated Data |
1 - 5 of 5
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_173228 (1) | 1717 nt | ||
Genomic | GenBank:CU929326 | 60413 nt | ||
Polypeptide | UniProtKB:A0A8N7UZT1 (1) | 443 aa |
No data available
- Jones, R.A., Cooper, F., Kelly, G., Barry, D., Renshaw, M.J., Sapkota, G., Smith, J.C. (2024) Zebrafish reveal new roles for Fam83f in hatching and the DNA damage-mediated autophagic response. Open Biology. 14:240194240194
- Cho, H.J., Lee, J.G., Kim, J.H., Kim, S.Y., Huh, Y.H., Kim, H.J., Lee, K.S., Yu, K., Lee, J.S. (2019) Vascular defects of DYRK1A knockouts are ameliorated by modulating calcium signaling in zebrafish. Disease models & mechanisms. 12(5):
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Wu, X.M., Cao, L., Hu, Y.W., Chang, M.X. (2019) Transcriptomic characterization of adult zebrafish infected with Streptococcus agalactiae. Fish & shellfish immunology. 94:355-372
- Takada, N., Omae, M., Sagawa, F., Chi, N.C., Endo, S., Kozawa, S., Sato, T.N. (2017) Re-evaluating functional landscape of the cardiovascular system during development. Biology Open. 6(11):1756-1770
- Wu, T.S., Lin, Y.T., Huang, Y.T., Cheng, Y.C., Yu, F.Y., Liu, B.H. (2017) Disruption of liver development and coagulation pathway by ochratoxin A in embryonic zebrafish. Toxicology and applied pharmacology. 340:1-8
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Lam, S.H., Winata, C.L., Tong, Y., Korzh, S., Lim, W.S., Korzh, V., Spitsbergen, J., Mathavan, S., Miller, L.D., Liu, E.T., and Gong, Z. (2006) Transcriptome Kinetics of Arsenic-induced Adaptive Response in Zebrafish Liver. Physiological Genomics. 27(3):351-361
1 - 10 of 14
Show