Gene
slc11a2
- ID
- ZDB-GENE-021115-1
- Name
- solute carrier family 11 member 2
- Symbol
- slc11a2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Enables iron ion transmembrane transporter activity. Acts upstream of or within several processes, including embryonic hemopoiesis; hemoglobin biosynthetic process; and response to copper ion. Predicted to be located in late endosome membrane and lysosome. Predicted to be active in endosome membrane; lysosomal membrane; and plasma membrane. Is expressed in several structures, including alar plate midbrain region; digestive system; hematopoietic system; solid lens vesicle; and ventral mesoderm. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease (multiple); inflammatory bowel disease (multiple); leishmaniasis (multiple); and tuberculosis (multiple). Orthologous to several human genes including SLC11A2 (solute carrier family 11 member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb426 (11 images)
- IMAGE:7138101 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| te216 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypochromic microcytic anemia | Alliance | Anemia, hypochromic microcytic, with iron overload 1 | 206100 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001046 | NRAMP family |
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Domain Details Per Protein
| Protein | Additional Resources | Length | NRAMP family |
|---|---|---|---|
| UniProtKB:Q1RLY4 | InterPro | 547 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc11a2-201
(1)
|
Ensembl | 1,663 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | EST | af190508 | ||
| Encodes | EST | cb426 | Thisse et al., 2001 | |
| Encodes | EST | fa07b10 | ||
| Encodes | EST | IMAGE:7138101 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:136699 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193641 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001040370 (1) | 2846 nt | ||
| Genomic | GenBank:CR855375 (1) | 178231 nt | ||
| Polypeptide | UniProtKB:Q1RLY4 (1) | 547 aa |
- Guo, J., Zou, Z., Dou, X., Zhao, X., Wang, Y., Wei, L., Pi, Y., Wang, Y., He, C., Guo, S. (2024) Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior. Nucleic acids research. 52(8):4257-4275
- Suzuki, H., Ogawa, T., Fujita, S., Sone, R., Kawahara, A. (2023) Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis. Scientific Reports. 13:1227912279
- Wang, Y., Bo, J., Zhao, Z., Han, Y., Zhang, Q., Liu, L. (2023) Depletion of Igfbp7 alleviates zebrafish NAFLD progression through inhibiting hepatic ferroptosis. Life sciences. 332:122086
- Chandrapalan, T., Kwong, R.W.M. (2020) Influence of dietary iron exposure on trace metal homeostasis and expression of metal transporters during development in zebrafish☆. Environmental pollution (Barking, Essex : 1987). 261:114159
- Hassan, A.T., Kwong, R.W.M. (2020) The neurophysiological effects of iron in early life stages of zebrafish. Environmental pollution (Barking, Essex : 1987). 267:115625
- Yang, T.T., Zhang, M.J., Fan, Z.J., Jiang, S.H., Liu, Q.N., Liu, M. (2019) Molecular identification and expression analysis of natural resistance-associated macrophage protein (Nramp) gene from yellow catfish Pelteobagrus fulvidraco (Siluriformes: Bagridae). International journal of biological macromolecules. 141:345-350
- Moore, C., Richens, J.L., Hough, Y., Ucanok, D., Malla, S., Sang, F., Chen, Y., Elworthy, S., Wilkinson, R.N., Gering, M. (2018) Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Blood advances. 2:2589-2606
- Duan, Z., Xing, Y., Feng, Z., Zhang, H., Li, C., Gong, Z., Wang, L., Sun, H. (2017) Hepatotoxicity of benzotriazole and its effect on the cadmium induced toxicity in zebrafish Danio rerio. Environmental pollution (Barking, Essex : 1987). 224:706-713
- Grillo, A.S., SantaMaria, A.M., Kafina, M.D., Cioffi, A.G., Huston, N.C., Han, M., Seo, Y.A., Yien, Y.Y., Nardone, C., Menon, A.V., Fan, J., Svoboda, D.C., Anderson, J.B., Hong, J.D., Nicolau, B.G., Subedi, K., Gewirth, A.A., Wessling-Resnick, M., Kim, J., Paw, B.H., Burke, M.D. (2017) Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals. Science (New York, N.Y.). 356:608-616
- White, R.J., Collins, J.E., Sealy, I.M., Wali, N., Dooley, C.M., Digby, Z., Stemple, D.L., Murphy, D.N., Billis, K., Hourlier, T., Füllgrabe, A., Davis, M.P., Enright, A.J., Busch-Nentwich, E.M. (2017) A high-resolution mRNA expression time course of embryonic development in zebrafish. eLIFE. 6
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