Gene

pwp2h

ID
ZDB-GENE-021031-3
Name
PWP2 small subunit processome component
Symbol
pwp2h Nomenclature History
Previous Names
  • cb471 (1)
  • titania (1)
  • tti
  • zgc:56063
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Acts upstream of or within digestive system development and ribosomal small subunit assembly. Predicted to be located in nucleolus. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Is expressed in several structures, including brain; digestive system; head; immature eye; and mesoderm. Orthologous to human PWP2 (PWP2 small subunit processome component).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Boglev et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ct143aGtTransgenic insertionUnknownUnknownDNA
la013618TgTransgenic insertionUnknownUnknownDNA
la021102TgTransgenic insertionUnknownUnknownDNA
s450Allele with one point mutationAcceptor Splice Site of Intron 9Cryptic Splice Site, Frameshift, Premature StopENU
s927Allele with one point mutationExon 5MissenseENU
sa14829Allele with one point mutationUnknownPremature StopENU
sa18575Allele with one point mutationUnknownPremature StopENU
sa19511Allele with one point mutationUnknownSplice SiteENU
sa32693Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-pwp2h
    Sun et al., 2019
    MO1-pwp2hN/ABoglev et al., 2013
    1 - 2 of 2
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    Human Disease
    Associated With pwp2h Human Ortholog
    No data available
    Associated With pwp2h Via Experimental Models
    No data available
    Gene Ontology
    Protein Domains
    Domain, Family, and Site Summary
    Type InterPro ID Name
    Conserved_site IPR019775 WD40 repeat, conserved site
    Domain IPR007148 Small-subunit processome, Utp12
    Family IPR027145 Periodic tryptophan protein 2
    Homologous_superfamily IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
    Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    1 - 5 of 7 Show all
    Domain Details Per Protein
    Protein Additional Resources Length G-protein beta WD-40 repeat Periodic tryptophan protein 2 Quinoprotein alcohol dehydrogenase-like superfamily Small-subunit processome, Utp12 WD40 repeat WD40 repeat, conserved site WD40/YVTN repeat-like-containing domain superfamily
    UniProtKB:Q7ZUV4 InterPro 937
    1 - 1 of 1
    Transcripts
    Genome Browsers
    Genome Build: GRCz11Chromosome: 1
    Type Name Annotation Method Has Havana Data Length (nt) Analysis
    mRNA pwp2h-201 (1) Ensembl 3,435 nt
    ncRNA pwp2h-002 (1) Ensembl 695 nt
    1 - 2 of 2
    Interactions and Pathways
    No data available
    Antibodies
    No data available
    Plasmids
    No data available
    Constructs
    No data available
    Marker Relationships
    Relationship Marker Type Marker Accession Numbers Citations
    Contained inBACCH73-98J8ZFIN Curated Data
    Contained inBACCH73-118M16ZFIN Curated Data
    EncodesESTcb471
    EncodesESTfz83e03
    EncodescDNAMGC:56063ZFIN Curated Data
    1 - 5 of 5
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    Sequences
    Orthology
    Comparative Orthology
    Alliance
    Gene Tree
    Ensembl
    Species Symbol Chromosome Accession # Evidence
    HumanPWP221
    Amino acid sequence comparison (1)
    MousePwp210
    Amino acid sequence comparison (1)
    Citations
    1 - 9 of 9
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