Gene
cbsb
- ID
- ZDB-GENE-021030-3
- Name
- cystathionine beta-synthase b
- Symbol
- cbsb Nomenclature History
- Previous Names
-
- cbs
- cb442 (1)
- wu:fb37g05
- wu:fm61c07
- wu:fq06c06
- zgc:113704
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable cystathionine beta-synthase activity. Acts upstream of or within axis elongation and regulation of homocysteine metabolic process. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including digestive system; germ ring; immature eye; musculature system; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including cerebral infarction; homocystinuria; hyperhomocysteinemia; malaria; and neural tube defect. Orthologous to human CBS (cystathionine beta-synthase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb442 (20 images)
- IMAGE:7147404 (15 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cbsb | (2) | |
| CRISPR2-cbsb | Jiang et al., 2020 | |
| MO1-cbsb | N/A | (2) |
| MO2-cbsb | N/A | (2) |
| MO3-cbsb | N/A | Prabhudesai et al., 2018 |
| MO4-cbsb | N/A | Prabhudesai et al., 2018 |
| MO5-cbsb | N/A | (2) |
1 - 7 of 7
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| homocystinuria | Alliance | Homocystinuria, B6-responsive and nonresponsive types | 236200 |
| homocystinuria | Alliance | Thrombosis, hyperhomocysteinemic | 236200 |
1 - 2 of 2
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR001216 | Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site |
| Domain | IPR000644 | CBS domain |
| Domain | IPR001926 | Tryptophan synthase beta chain-like, PALP domain |
| Domain | IPR046353 | Cystathionine beta-synthase, C-terminal domain |
| Family | IPR005857 | Cystathionine beta-synthase |
1 - 5 of 8 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | CBS domain | CBS domain superfamily | Cystathionine beta-synthase | Cystathionine beta-synthase, C-terminal domain | Cysteine synthase/Cystathionine beta-synthase | Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site | Tryptophan synthase beta chain-like, PALP domain | Tryptophan synthase beta chain-like, PALP domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5EI65 | InterPro | 597 | ||||||||
| UniProtKB:A0A8M1N4Z7 | InterPro | 597 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-214P13 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-392N17 | ZFIN Curated Data | |
| Encodes | EST | cb442 | Thisse et al., 2001 | |
| Encodes | EST | fb37g05 | ||
| Encodes | EST | fb83h03 | Rauch et al., 2003 | |
| Encodes | EST | fm61c07 | ZFIN Curated Data | |
| Encodes | EST | fq06c06 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7147404 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:113704 | ZFIN Curated Data |
1 - 9 of 9
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001014345 (1) | 2857 nt | ||
| Genomic | GenBank:AL954142 (2) | 238837 nt | ||
| Polypeptide | UniProtKB:A0A8M1N4Z7 (1) | 597 aa |
- Chatterjee, B., Fatima, F., Seth, S., Sinha Roy, S. (2024) Moderate Elevation of Homocysteine Induces Endothelial Dysfunction through Adaptive UPR Activation and Metabolic Rewiring. Cells. 13(3):
- Freeburg, S.H., Shwartz, A., Kemény, L.V., Smith, C.J., Weeks, O., Miller, B.M., PenkoffLidbeck, N., Fisher, D.E., Evason, K.J., Goessling, W. (2024) Hepatocyte vitamin D receptor functions as a nutrient sensor that regulates energy storage and tissue growth in zebrafish. Cell Reports. 43:114393114393
- Koslow, M., Zhu, P., McCabe, C., Xu, X., Lin, X. (2023) Kidney transcriptome and cystic kidney disease genes in zebrafish. Frontiers in Physiology. 14:11840251184025
- Zhang, F., Zeng, Q.Y., Xu, H., Xu, A.N., Liu, D.J., Li, N.Z., Chen, Y., Jin, Y., Xu, C.H., Feng, C.Z., Zhang, Y.L., Liu, D., Liu, N., Xie, Y.Y., Yu, S.H., Yuan, H., Xue, K., Shi, J.Y., Liu, T.X., Xu, P.F., Zhao, W.L., Zhou, Y., Wang, L., Huang, Q.H., Chen, Z., Chen, S.J., Zhou, X.L., Sun, X.J. (2021) Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis. Cell discovery. 7:98
- Dey, A., Prabhudesai, S., Zhang, Y., Rao, G., Thirugnanam, K., Hossen, M.N., Dwivedi, S.K.D., Ramchandran, R., Mukherjee, P., Bhattacharya, R. (2020) Cystathione β-synthase regulates HIF-1α stability through persulfidation of PHD2. Science advances. 6(27):
- Jiang, W., Liu, C., Deng, M., Wang, F., Ren, X., Fan, Y., Du, J., Wang, Y. (2020) H2S promotes developmental brain angiogenesis via the NOS/NO pathway in zebrafish. Stroke and vascular neurology. 6(2):244-251
- Adam, A.C., Skjærven, K.H., Whatmore, P., Moren, M., Lie, K.K. (2018) Parental high dietary arachidonic acid levels modulated the hepatic transcriptome of adult zebrafish (Danio rerio) progeny. PLoS One. 13:e0201278
- Perna, A.F., Anishchenko, E., Vigorito, C., Zacchia, M., Trepiccione, F., D'Aniello, S., Ingrosso, D. (2018) Zebrafish, a Novel Model System to Study Uremic Toxins: The Case for the Sulfur Amino Acid Lanthionine. International Journal of Molecular Sciences. 19(5)
- Prabhudesai, S., Koceja, C., Dey, A., Eisa-Beygi, S., Leigh, N.R., Bhattacharya, R., Mukherjee, P., Ramchandran, R. (2018) Cystathionine β-Synthase Is Necessary for Axis Development in Vivo.. Frontiers in cell and developmental biology. 6:14
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
1 - 10 of 19
Show