Gene
foxn1
- ID
- ZDB-GENE-021008-1
- Name
- forkhead box N1
- Symbol
- foxn1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Enables transcription cis-regulatory region binding activity. Acts upstream of or within adaptive immune response; regulation of T cell differentiation in thymus; and thymus development. Predicted to be located in nucleus. Is expressed in pharyngeal arch; pharyngeal arch 3-7 skeleton; thymic epithelium; thymus; and thymus primordium. Human ortholog(s) of this gene implicated in T-cell immunodeficiency, congenital alopecia, and nail dystrophy; alopecia; nail disease; and primary immunodeficiency disease. Orthologous to human FOXN1 (forkhead box N1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 44 figures from 38 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fr107 | Allele with one delins | Unknown | Unknown | CRISPR | |
| ioz112 | Allele with one delins | Unknown | Premature Stop | zinc finger nuclease | |
| sa35901 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45541 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-foxn1 | (2) | |
| CRISPR2-foxn1 | (3) | |
| CRISPR3-foxn1 | (3) | |
| MO1-foxn1 | N/A | Bajoghli et al., 2009 |
| MO2-foxn1 | N/A | Bajoghli et al., 2009 |
| MO3-foxn1 | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| T-cell immunodeficiency, congenital alopecia, and nail dystrophy | Alliance | T-cell immunodeficiency, congenital alopecia, and nail dystrophy | 601705 |
| T-cell lymphopenia, infantile, with or without nail dystrophy, autosomal dominant | 618806 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Domain | IPR047401 | Forkhead box protein N1, forkhead domain |
| Family | IPR049624 | Forkhead box protein N1/4 |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead box protein N1/4 | Forkhead box protein N1, forkhead domain | Fork head domain | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZTC0 | InterPro | 565 | ||||||
| UniProtKB:F1R9K2 | InterPro | 565 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(foxn1:mCherry) |
|
| 1 | (5) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-234F12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193870 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212573 (1) | 1911 nt | ||
| Genomic | GenBank:BX663513 (1) | 249413 nt | ||
| Polypeptide | UniProtKB:F1R9K2 (1) | 565 aa |
- Liu, M., Li, Y., Deng, Z., Zhang, K., Huang, S., Xia, J., Feng, Y., Liang, Y., Sun, C., Liu, X., Li, S., Su, B., Dong, Y., Huang, S. (2025) Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage. Cell Death & Disease. 16:8484
- Sertori, R., Truong, B., Singh, M.K., Shinton, S., Price, R., Sharo, A., Shultes, P., Sunderam, U., Rana, S., Srinivasan, R., Datta, S., Font-Burgada, J., Brenner, S.E., Puck, J.M., Wiest, D.L. (2025) Disruption of the moonlighting function of CTF18 in a patient with T-lymphopenia. Frontiers in immunology. 16:15398481539848
- Lawir, D.F., Soza-Ried, C., Iwanami, N., Siamishi, I., Bylund, G.O., O Meara, C., Sikora, K., Kanzler, B., Johansson, E., Schorpp, M., Cauchy, P., Boehm, T. (2024) Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish. Communications biology. 7:3131
- Luo, H., Li, Q., Hong, J., Huang, Z., Deng, W., Wei, K., Lu, S., Wang, H., Zhang, W., Liu, W. (2024) Targeting TNF/IL-17/MAPK pathway in hE2A-PBX1 leukemia: effects of OUL35, KJ-Pyr-9, and CID44216842. Haematologica. 109(7):2092-2110
- Li, H., Luo, Q., Cai, S., Tie, R., Meng, Y., Shan, W., Xu, Y., Zeng, X., Qian, P., Huang, H. (2023) Glia maturation factor-γ is required for initiation and maintenance of hematopoietic stem and progenitor cells. Stem Cell Research & Therapy. 14:117117
- Schorpp, M., Swann, J.B., Hess, I., Ho, H.C., Pietsch, T.W., Boehm, T. (2023) Foxn1 is not essential for T-cell development in teleosts. European journal of immunology. 53(12):e2350725
- Yang, S., Xu, X., Yin, Z., Liu, Y., Wang, H., Guo, J., Wang, F., Bao, Y., Zhang, T., Sun, S. (2023) nkx2.3 is responsible for posterior pharyngeal cartilage formation by inhibiting Fgf signaling. Heliyon. 9:e21915e21915
- Sertori, R., Lin, J.X., Martinez, E., Rana, S., Sharo, A., Kazemian, M., Sunderam, U., Andrake, M., Shinton, S., Truong, B., Dunbrack, R.M., Liu, C., Srinivasan, R., Brenner, S.E., Seroogy, C.M., Puck, J.M., Leonard, W.J., Wiest, D.L. (2022) Investigation of the causal etiology in a patient with T-B+NK+ immunodeficiency. Frontiers in immunology. 13:928252
- Lim, J.Y., Kim, Y.J., Woo, S.A., Jeong, J.W., Lee, Y.R., Kim, C.H., Park, H.M. (2021) The LAMMER Kinase, LkhA, Affects Aspergillus fumigatus Pathogenicity by Modulating Reproduction and Biosynthesis of Cell Wall PAMPs. Frontiers in cellular and infection microbiology. 11:756206
- Lin, Z., Luo, M., Zhou, B., Liu, Y., Sun, H. (2021) CFTR regulates embryonic T lymphopoiesis via Wnt signaling in zebrafish. Immunology Letters. 234:47-53
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