Gene
copa
- ID
- ZDB-GENE-020905-2
- Name
- COPI coat complex subunit alpha
- Symbol
- copa Nomenclature History
- Previous Names
-
- cb281 (1)
- fb13c12
- sneezy
- wu:fb13c12
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable structural molecule activity. Acts upstream of or within notochord development and somite development. Predicted to be located in COPI-coated vesicle membrane and Golgi membrane. Predicted to be part of COPI vesicle coat. Is expressed in several structures, including axis; hatching gland; mesoderm; notochord; and pectoral fin. Human ortholog(s) of this gene implicated in autoimmune interstitial lung, joint, and kidney disease. Orthologous to human COPA (COPI coat complex subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb281 (6 images)
- IMAGE:7152734 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 22 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi1872Tg | Transgenic insertion | 5' UTR | Unknown | DNA | |
| hi2203Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| hi3669Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| la010427Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| m456 | Allele with one point mutation | Donor Splice Site | Cryptic Acceptor Splice Site, Frameshift, Premature Stop | ENU | |
| td204a | unknown | Unknown | Unknown | ENU | |
| tm11 | unknown | Unknown | Unknown | ENU | |
| tm75 | unknown | Unknown | Unknown | ENU | |
| tn211 | unknown | Unknown | Unknown | ENU | |
| tq249b | unknown | Unknown | Unknown | ENU |
1 - 10 of 10
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autoimmune interstitial lung, joint, and kidney disease | Alliance | {Autoinflammation and autoimmunity, systemic, with immune dysregulation} | 616414 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Coatomer, alpha subunit, C-terminal | Coatomer complex subunit | Coatomer subunit alpha | Coatomer subunit alpha, WD Associated Region | COPA/B second beta-propeller domain | COPA/B, TPR domain | G-protein beta WD-40 repeat | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DRK5 | InterPro | 1224 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-52K20 | ZFIN Curated Data | |
| Encodes | EST | cb281 | Thisse et al., 2001 | |
| Encodes | EST | fb13c12 | ||
| Encodes | EST | IMAGE:7152734 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:171377 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193571 | ZFIN Curated Data |
1 - 6 of 6
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001001941 (1) | 4096 nt | ||
| Genomic | GenBank:BX649372 (1) | 249584 nt | ||
| Polypeptide | UniProtKB:Q6DRK5 (1) | 1224 aa |
- Guillemyn, B., De Saffel, H., Bek, J.W., Tapaneeyaphan, P., De Clercq, A., Jarayseh, T., Debaenst, S., Willaert, A., De Rycke, R., Byers, P.H., Rosseel, T., Coucke, P., Blaumeiser, B., Syx, D., Malfait, F., Symoens, S. (2023) Syntaxin 18 Defects in Human and Zebrafish Unravel Key Roles in Early Cartilage and Bone Development. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 38(11):1718-1730
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Chen, J., Wu, X., Yao, L., Yan, L., Zhang, L., Qiu, J., Liu, X., Jia, S., Meng, A. (2017) Impairment of Cargo Transportation Caused by gbf1 Mutation Disrupts Vascular Integrity and Causes Hemorrhage in Zebrafish Embryos.. The Journal of biological chemistry. 292(6):2315-2327
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lim, A., Moussavi Nik, S.H., Ebrahimie, E., Lardelli, M. (2015) Analysis of nicastrin gene phylogeny and expression in zebrafish. Development genes and evolution. 225(3):171-8
- Shamay-Ramot, A., Khermesh, K., Porath, H.T., Barak, M., Pinto, Y., Wachtel, C., Zilberberg, A., Lerer-Goldshtein, T., Efroni, S., Levanon, E.Y., Appelbaum, L. (2015) Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish. PLoS Genetics. 11:e1005702
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Barresi, M.J., Burton, S., Dipietrantonio, K., Amsterdam, A., Hopkins, N., and Karlstrom, R.O. (2010) Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(10):2603-2618
- Hawkins, T.A., Cavodeassi, F., Erdelyi, F., Szabo, G., and Lele, Z. (2008) The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish. BMC Developmental Biology. 8(1):42
- Lemeer, S., Jopling, C., Gouw, J.W., Mohammed, S., Heck, A.J., Slijper, M., and den Hertog, J. (2008) Comparative phosphoproteomics of zebrafish Fyn/Yes morpholino knockdown embryos. Molecular & cellular proteomics : MCP. 7(11):2176-2187
1 - 10 of 19
Show