Gene
sim1a
- ID
- ZDB-GENE-020829-1
- Name
- SIM bHLH transcription factor 1a
- Symbol
- sim1a Nomenclature History
- Previous Names
-
- sim1
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within nervous system development and proximal tubule development. Predicted to be active in nucleus. Is expressed in several structures, including basal plate midbrain region; central nervous system; corpuscles of Stannius; intermediate mesoderm; and pronephros. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SIM1 (SIM bHLH transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 40 figures from 25 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa2864 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa30996 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa36012 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42640 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42641 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf3867Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-sim1a | Böhm et al., 2022 | |
| CRISPR2-sim1a | Mazzaferro et al., 2025 | |
| MO1-sim1a | N/A | (7) |
| MO2-sim1a | N/A | (5) |
| MO3-sim1a | N/A | Borodovsky et al., 2009 |
| MO4-sim1a | N/A | Borodovsky et al., 2009 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | PAC motif | PAS domain | PAS domain superfamily | PAS fold | PAS fold-3 | Single-minded, C-terminal |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QMF7 | InterPro | 745 | ||||||||
| UniProtKB:Q98SJ5 | InterPro | 745 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-167H2 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-265C18 | ZFIN Curated Data | |
| Encodes | EST | ay028626 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_178222 (1) | 2655 nt | ||
| Genomic | GenBank:BX005277 (2) | 137475 nt | ||
| Polypeptide | UniProtKB:F1QMF7 (1) | 745 aa |
- Mazzaferro, E., Mujica, E., Zhang, H., Emmanouilidou, A., Jenseit, A., Evcimen, B., Metzendorf, C., Dethlefsen, O., Loos, R.J., Vienberg, S.G., Larsson, A., Allalou, A., den Hoed, M. (2025) Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning. Scientific Reports. 15:54085408
- Zhang, Q., Li, F., Li, T., Lin, J., Jian, J., Zhang, Y., Chen, X., Liu, T., Gou, S., Zhang, Y., Liu, X., Ji, Y., Wang, X., Li, Q. (2024) Nomo1 deficiency causes autism-like behavior in zebrafish. EMBO reports. 25(2):570-592
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Lin, C.Y., Yeh, K.Y., Lai, H.H., Her, G.M. (2023) AgRP Neuron-Specific Ablation Represses Appetite, Energy Intake, and Somatic Growth in Larval Zebrafish. Biomedicines. 11(2):
- Böhm, U.L., Kimura, Y., Kawashima, T., Ahrens, M.B., Higashijima, S.I., Engert, F., Cohen, A.E. (2022) Voltage imaging identifies spinal circuits that modulate locomotor adaptation in zebrafish. Neuron. 110(7):1211-1222.e4
- Jacobs, C.T., Kejriwal, A., Kocha, K.M., Jin, K.Y., Huang, P. (2022) Temporal cell fate determination in the spinal cord is mediated by the duration of Notch signalling. Developmental Biology. 489:1-13
- Wang, R., Guo, S., Yang, L. (2022) Tal2 is required for generation of GABAergic neurons in the zebrafish midbrain. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(2):263-275
- Westphal, M., Panza, P., Kastenhuber, E., Wehrle, J., Driever, W. (2022) Wnt/β-catenin signaling promotes neurogenesis in the diencephalospinal dopaminergic system of embryonic zebrafish. Scientific Reports. 12:1030
- Chu, S., Kwon, B.R., Lee, Y.M., Zoh, K.D., Choi, K. (2021) Effects of 2-ethylhexyl-4-methoxycinnamate (EHMC) on thyroid hormones and genes associated with thyroid, neurotoxic, and nephrotoxic responses in adult and larval zebrafish (Danio rerio). Chemosphere. 263:128176
- Danesin, C., Darche-Gabinaud, R., Escalas, N., Bouguetoch, V., Cochard, P., Al Oustah, A., Ohayon, D., Glise, B., Soula, C. (2021) Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord. Scientific Reports. 11:118
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