Gene
has2
- ID
- ZDB-GENE-020828-1
- Name
- hyaluronan synthase 2
- Symbol
- has2 Nomenclature History
- Previous Names
-
- DG42 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable hyaluronan synthase activity. Acts upstream of or within several processes, including circulatory system development; dorsal convergence; and fin regeneration. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; mesoderm; pericardial region; presumptive paraxial mesoderm; and swim bladder bud. Orthologous to human HAS2 (hyaluronan synthase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 64 figures from 44 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu226 (25 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-has2 | Capon et al., 2017 | |
| MO1-has2 | N/A | (10) |
| MO2-has2 | N/A | (3) |
| MO3-has2 | N/A | Rost et al., 2014 |
| MO4-has2 | N/A | (2) |
| MO5-has2 | N/A | Govindan et al., 2016 |
| MO6-has2 | N/A | Khatib et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Homologous_superfamily | IPR029044 | Nucleotide-diphospho-sugar transferases |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleotide-diphospho-sugar transferases |
|---|---|---|---|
| UniProtKB:Q9DG41 | InterPro | 552 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-221N14 | ZFIN Curated Data | |
| Encodes | EST | af190742 | Bakkers et al., 2004 | |
| Encodes | EST | eu226 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:114015 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_153650 (1) | 2895 nt | ||
| Genomic | GenBank:BX936449 (2) | 145798 nt | ||
| Polypeptide | UniProtKB:Q9DG41 (1) | 552 aa |
- Prill, K., Windsor Reid, P., Pilgrim, D. (2025) Heart Morphogenesis Requires Smyd1b for Proper Incorporation of the Second Heart Field in Zebrafish. Genes. 16:
- Zhou, W., Cai, W., Li, Y., Gao, L., Liu, X., Liu, S., Lei, J., Zhang, J., Wang, Y., Jiang, Z., Wu, X., Fan, X., Li, F., Zheng, L., Yuan, W. (2025) The Interaction Between the asb5a and asb5b Subtypes Jointly Regulates the L-R Asymmetrical Development of the Heart in Zebrafish. International Journal of Molecular Sciences. 26:
- da Silva, A.R., Gunawan, F., Boezio, G.L.M., Faure, E., Théron, A., Avierinos, J.F., Lim, S., Jha, S.G., Ramadass, R., Guenther, S., Looso, M., Zaffran, S., Juan, T., Stainier, D.Y.R. (2024) egr3 is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis. Science advances. 10:eadl0633
- Sam, J., Torregroza, I., Evans, T. (2024) Gata6 functions in zebrafish endoderm to regulate late differentiating arterial pole cardiogenesis. Development (Cambridge, England). 151(17):
- Uju, C., Karimzadeh, K., Unniappan, S. (2024) Brain Derived Neurotrophic Factor Stimulates Hypothalamic and Gonadal Reproductive Hormones and Oocyte Maturation in Zebrafish. Reproduction (Cambridge, England). 169(1):
- Xu, W., Liu, X., Li, J., Sun, C., Chen, L., Zhou, J., Li, K., Li, Q., Meng, A., Sun, Q. (2024) ULI-ssDRIP-seq revealed R-loop dynamics during vertebrate early embryogenesis. Cell insight. 3:100179100179
- Sugitani, K., Mokuya, T., Homma, S., Maeda, M., Konno, A., Ogai, K. (2023) Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration. International Journal of Molecular Sciences. 24(4):
- Wang, H., He, J., Han, X., Wu, X., Ye, X., Lv, W., Zu, Y. (2023) hoxa1a-Null Zebrafish as a Model for Studying HOXA1-Associated Heart Malformation in Bosley-Salih-Alorainy Syndrome. Biology. 12(7):
- Liu, Y., Lin, Z., Peng, Y., Jiang, Y., Zhang, X., Zhu, H., Zhang, L., Chen, J., Shu, X., Luo, M., Xie, D., Chen, Y., Liao, H., Liu, M., Zhang, X., Liu, S., Wang, H., Zhou, B., Sun, H. (2022) Embryonic organizer formation disorder leads to multiorgan dysplasia in Down syndrome. Cell Death & Disease. 13:10541054
- Ma, J., Gu, Y., Liu, J., Song, J., Zhou, T., Jiang, M., Wen, Y., Guo, X., Zhou, Z., Sha, J., He, J., Hu, Z., Luo, L., Liu, M. (2022) Functional screening of congenital heart disease risk loci identifies 5 genes essential for heart development in zebrafish. Cellular and molecular life sciences : CMLS. 80:1919
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