Gene
caspb
- ID
- ZDB-GENE-020812-1
- Name
- caspase b
- Symbol
- caspb Nomenclature History
- Previous Names
-
- caspy2
- casp19a (1)
- zgc:109807
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables aspartic-type peptidase activity; cysteine-type endopeptidase activity; and lipopolysaccharide binding activity. Involved in several processes, including defense response to bacterium; positive regulation of pyroptotic inflammatory response; and self proteolysis. Acts upstream of or within positive regulation of apoptotic process; pyroptotic inflammatory response; and response to bacterium. Part of NLRP1 inflammasome complex. Is expressed in several structures, including digestive system; heart; immune system; integument; and muscle. Orthologous to human CASP4 (caspase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109807 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| eib1 | Allele with one delins | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-caspb | Kenyon et al., 2017 | |
| CRISPR2-caspb | Kenyon et al., 2017 | |
| CRISPR3-caspb | Kenyon et al., 2017 | |
| CRISPR4-caspb | (3) | |
| CRISPR5-caspb,caspbl | Yang et al., 2018 | |
| MO1-caspb | N/A | (2) |
| MO2-caspb | N/A | Li et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016129 | Peptidase family C14A, His active site |
| Active_site | IPR033139 | Peptidase family C14A, cysteine active site |
| Domain | IPR001309 | Peptidase C14, p20 domain |
| Domain | IPR002138 | Peptidase C14, caspase non-catalytic subunit p10 |
| Domain | IPR004020 | DAPIN domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Caspase-like domain superfamily | DAPIN domain | Death-like domain superfamily | Peptidase C14A, caspase catalytic domain | Peptidase C14, caspase domain | Peptidase C14, caspase non-catalytic subunit p10 | Peptidase C14 family | Peptidase C14, p20 domain | Peptidase family C14A, cysteine active site | Peptidase family C14A, His active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q504J1 | InterPro | 404 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-114L13 | ZFIN Curated Data | |
| Encodes | EST | fl61f11 | ||
| Encodes | cDNA | MGC:109807 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191673 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_152884 (1) | 1812 nt | ||
| Genomic | GenBank:BX469930 (1) | 183380 nt | ||
| Polypeptide | UniProtKB:Q504J1 (1) | 404 aa |
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Removed orthology to human CASP1 curated from Woods et al. 2005. Not clear if CASP1 or CASP5 is ortholog.
No data available
- Zhang, Z., Zhang, H.L., Yang, D.H., Hao, Q., Yang, H.W., Meng, D.L., Meindert de Vos, W., Guan, L.L., Liu, S.B., Teame, T., Gao, C.C., Ran, C., Yang, Y.L., Yao, Y.Y., Ding, Q.W., Zhou, Z.G. (2024) Lactobacillus rhamnosus GG triggers intestinal epithelium injury in zebrafish revealing host dependent beneficial effects. iMeta. 3:e181e181
- Sellaththurai, S., Jung, S., Kim, M.J., Nadarajapillai, K., Ganeshalingam, S., Jeong, J.B., Lee, J. (2023) CRISPR/Cas9-Induced Knockout of Sting Increases Susceptibility of Zebrafish to Bacterial Infection. Biomolecules. 13(2):
- Shkarina, K., Hasel de Carvalho, E., Santos, J.C., Ramos, S., Leptin, M., Broz, P. (2022) Optogenetic activators of apoptosis, necroptosis, and pyroptosis. The Journal of cell biology. 221(6):
- Zhao, Y., Wang, H., Duah, P.A., Retyunskiy, V., Liu, Y., Chen, G. (2022) Zinc pyrithione (ZPT) -induced embryonic toxicogenomic responses reveal involvement of oxidative damage, apoptosis, endoplasmic reticulum (ER) stress and autophagy. Aquatic toxicology (Amsterdam, Netherlands). 248:106195
- Chen, W., Zhao, J., Mu, D., Wang, Z., Liu, Q., Zhang, Y., Yang, D. (2021) Pyroptosis Mediates Neutrophil Extracellular Trap Formation during Bacterial Infection in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 206(8):1913-1922
- Liu, X., Xie, X., Liu, H. (2021) Effects of Diethylstilbestrol on Zebrafish Gonad Development and Endocrine Disruption Mechanism. Biomolecules. 11(7):
- Molagoda, I.M.N., Athapaththu, A.M.G.K., Choi, Y.H., Park, C., Jin, C.Y., Kang, C.H., Lee, M.H., Kim, G.Y. (2021) Fisetin Inhibits NLRP3 Inflammasome by Suppressing TLR4/MD2-Mediated Mitochondrial ROS Production. Antioxidants (Basel, Switzerland). 10(8):
- Angileri, K.M., Gross, J.M. (2020) dnmt1 function is required to maintain retinal stem cells within the ciliary marginal zone of the zebrafish eye. Scientific Reports. 10:11293
- Wang, Z., Gu, Z., Hou, Q., Chen, W., Mu, D., Zhang, Y., Liu, Q., Liu, Z., Yang, D. (2020) Zebrafish GSDMEb Cleavage-Gated Pyroptosis Drives Septic-Acute Kidney Injury In Vivo. Journal of immunology (Baltimore, Md. : 1950). 204(7):1929-1942
- Li, J.Y., Wang, Y.Y., Shao, T., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2019) The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E-mediated pyroptosis. The Journal of biological chemistry. 295(4):1120-1141
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