Gene
tagln2
- ID
- ZDB-GENE-020802-2
- Name
- transgelin 2
- Symbol
- tagln2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Acts upstream of or within several processes, including actin cytoskeleton organization; blood vessel remodeling; and endothelial cell migration. Located in actin cytoskeleton. Is expressed in several structures, including EVL; anterior axial hypoblast; gut; periderm; and vasculature. Orthologous to human TAGLN (transgelin) and TAGLN2 (transgelin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb223 (15 images)
- eu907 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Wen et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cqu1 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tagln2 | Wen et al., 2021 | |
| MO1-tagln2 | N/A | Yang et al., 2003 |
| MO2-tagln2 | N/A | Wen et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Calponin homology domain | Calponin-like | Calponin repeat | CH domain superfamily | Smooth muscle protein/calponin |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6TGT5 | InterPro | 201 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tagln2-201
(1)
|
Ensembl | 1,355 nt | ||
| mRNA |
tagln2-202
(1)
|
Ensembl | 615 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-110C7 | ZFIN Curated Data | |
| Contains | SNP | rs3727881 | ZFIN Curated Data | |
| Contains | SNP | rs3727882 | ZFIN Curated Data | |
| Contains | SNP | rs3727883 | ZFIN Curated Data | |
| Contains | SNP | rs3727884 | ZFIN Curated Data | |
| Contains | SNP | rs3727885 | ZFIN Curated Data | |
| Encodes | EST | cb223 | Thisse et al., 2001 | |
| Encodes | EST | eu907 | Thisse et al., 2005 | |
| Encodes | EST | fa92e03 | ||
| Encodes | EST | fb11g09 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201576 (1) | 1336 nt | ||
| Genomic | GenBank:BX510647 (1) | 198695 nt | ||
| Polypeptide | UniProtKB:Q6TGT5 (1) | 201 aa |
No data available
- Bhattarai, P., Gunasekaran, T.I., Belloy, M.E., Reyes-Dumeyer, D., Jülich, D., Tayran, H., Yilmaz, E., Flaherty, D., Turgutalp, B., Sukumar, G., Alba, C., McGrath, E.M., Hupalo, D.N., Bacikova, D., Le Guen, Y., Lantigua, R., Medrano, M., Rivera, D., Recio, P., Nuriel, T., Ertekin-Taner, N., Teich, A.F., Dickson, D.W., Holley, S., Greicius, M., Dalgard, C.L., Zody, M., Mayeux, R., Kizil, C., Vardarajan, B.N. (2024) Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease. Acta Neuropathologica. 147:7070
- Wen, L., Zhang, T., Wang, J., Jin, X., Rouf, M.A., Luo, D., Zhu, Y., Lei, D., Gregersen, H., Wang, Y., Wang, G. (2021) The blood flow-klf6a-tagln2 axis drives vessel pruning in zebrafish by regulating endothelial cell rearrangement and actin cytoskeleton dynamics. PLoS Genetics. 17:e1009690
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Kotkamp, K., Mössner, R., Allen, A., Onichtchouk, D., and Driever, W. (2014) A Pou5f1/Oct4 dependent Klf2a, Klf2b, and Klf17 regulatory sub-network contributes to EVL and ectoderm development during zebrafish embryogenesis. Developmental Biology. 385(2):433-47
- Lundquist, M.R., Storaska, A.J., Liu, T.C., Larsen, S.D., Evans, T., Neubig, R.R., Jaffrey, S.R. (2014) Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.. Cell. 156(3):563-76
- Wang, Y., Pan, L., Moens, C.B., and Appel, B. (2014) Notch3 establishes brain vascular integrity by regulating pericyte number. Development (Cambridge, England). 141(2):307-317
- Seiler, C., Abrams, J., and Pack, M. (2010) Characterization of zebrafish intestinal smooth muscle development using a novel sm22{alpha}-b promoter. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(11):2806-2812
- Santoro, M.M., Pesce, G., and Stainier, D.Y. (2009) Characterization of vascular mural cells during zebrafish development. Mechanisms of Development. 126(8-9):638-649
- Brown, J.L., Snir, M., Noushmehr, H., Kirby, M., Hong, S.K., Elkahloun, A.G., and Feldman, B. (2008) Transcriptional profiling of endogenous germ layer precursor cells identifies dusp4 as an essential gene in zebrafish endoderm specification. Proceedings of the National Academy of Sciences of the United States of America. 105(34):12337-12342
- Leung, Y.F., Ma, P., and Dowling, J.E. (2007) Gene expression profiling of zebrafish embryonic retinal pigment epithelium in vivo. Investigative ophthalmology & visual science. 48(2):881-890
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