Gene
mycn
- ID
- ZDB-GENE-020711-1
- Name
- MYCN proto-oncogene, bHLH transcription factor
- Symbol
- mycn Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity; DNA-binding transcription factor activity; and protein dimerization activity. Predicted to be involved in hematopoietic progenitor cell differentiation. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in several structures, including immature eye; nervous system; pectoral fin bud; pharyngeal arch; and vagal neural crest. Human ortholog(s) of this gene implicated in Feingold syndrome. Orthologous to human MYCN (MYCN proto-oncogene, bHLH transcription factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mycn | Li et al., 2022 | |
| CRISPR2-mycn | Li et al., 2022 | |
| CRISPR3-mycn | Li et al., 2022 | |
| CRISPR4-mycn | Li et al., 2022 | |
| CRISPR5-mycn | Li et al., 2022 | |
| CRISPR6-mycn | Li et al., 2022 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Feingold syndrome | Alliance | Feingold syndrome 1 | 164280 |
| Megalencephaly-polydactyly syndrome | 620748 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR012682 | Transcription regulator Myc, N-terminal |
| Family | IPR002418 | Transcription regulator Myc |
| Family | IPR050433 | Myc family transcription factors |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | Myc family transcription factors | Myc-type, basic helix-loop-helix (bHLH) domain | Transcription regulator Myc | Transcription regulator Myc, N-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q9PSJ0 | InterPro | ||||||
| UniProtKB:Q5GFD4 | InterPro | 456 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212614 (1) | 2734 nt | ||
| Genomic | GenBank:BX005358 (2) | 181198 nt | ||
| Polypeptide | UniProtKB:Q5GFD4 (1) | 456 aa |
- Wang, W., Yang, N., Wang, L., Zhu, Y., Chu, X., Xu, W., Li, Y., Xu, Y., Gao, L., Zhang, B., Zhang, G., Sun, Q., Wang, W., Wang, Q., Zhang, W., Chen, D. (2024) The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development. Cell Reports. 43:113873113873
- Heng, J., Shi, B., Zhou, J.Y., Zhang, Y., Ma, D., Yang, Y.G., Liu, F. (2023) Cpeb1b-mediated cytoplasmic polyadenylation of shha mRNA modulates zebrafish definitive hematopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 120:e2212212120e2212212120
- Chen, X., Liu, F., Chen, K., Wang, Y., Yin, A., Kang, X., Yang, S., Zhao, H., Dong, S., Li, Y., Chen, J., Wu, Y. (2022) TFG mutation induces haploinsufficiency and drives axonal Charcot-Marie-Tooth disease by causing neurite degeneration. CNS neuroscience & therapeutics. 28(12):2076-2089
- Li, Y.F., Cheng, T., Zhang, Y.J., Fu, X.X., Mo, J., Zhao, G.Q., Xue, M.G., Zhuo, D.H., Xing, Y.Y., Huang, Y., Sun, X.Z., Wang, D., Liu, X., Dong, Y., Zhu, X.S., He, F., Ma, J., Chen, D., Jin, X., Xu, P.F. (2022) Mycn regulates intestinal development through ribosomal biogenesis in a zebrafish model of Feingold syndrome 1. PLoS Biology. 20:e3001856
- Nunes, C., Depestel, L., Mus, L., Keller, K.M., Delhaye, L., Louwagie, A., Rishfi, M., Whale, A., Kara, N., Andrews, S.R., Dela Cruz, F., You, D., Siddiquee, A., Cologna, C.T., De Craemer, S., Dolman, E., Bartenhagen, C., De Vloed, F., Sanders, E., Eggermont, A., Bekaert, S.L., Van Loocke, W., Bek, J.W., Dewyn, G., Loontiens, S., Van Isterdael, G., Decaesteker, B., Tilleman, L., Van Nieuwerburgh, F., Vermeirssen, V., Van Neste, C., Ghesquiere, B., Goossens, S., Eyckerman, S., De Preter, K., Fischer, M., Houseley, J., Molenaar, J., De Wilde, B., Roberts, S.S., Durinck, K., Speleman, F. (2022) RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition. Science advances. 8:eabn1382
- Dong, Z., Yeo, K.S., Lopez, G., Zhang, C., Dankert Eggum, E.N., Rokita, J.L., Ung, C.Y., Levee, T.M., Her, Z.P., Howe, C.J., Hou, X., van Ree, J.H., Li, S., He, S., Tao, T., Fritchie, K., Torres-Mora, J., Lehman, J.S., Meves, A., Razidlo, G.L., Rathi, K.S., Weroha, S.J., Look, A.T., van Deursen, J.M., Li, H., Westendorf, J.J., Maris, J.M., Zhu, S. (2021) GAS7 Deficiency Promotes Metastasis in MYCN-driven Neuroblastoma. Cancer research. 81(11):2995-3007
- Raby, L., Völkel, P., Hasanpour, S., Cicero, J., Toillon, R.A., Adriaenssens, E., Van Seuningen, I., Le Bourhis, X., Angrand, P.O. (2021) Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish. Cells. 10(11):
- Tao, L., Moreno-Smith, M., Ibarra-García-Padilla, R., Milazzo, G., Drolet, N.A., Hernandez, B.E., Oh, Y.S., Patel, I., Kim, J.J., Zorman, B., Patel, T., Kamal, A.H.M., Zhao, Y., Hicks, J., Vasudevan, S.A., Putluri, N., Coarfa, C., Sumazin, P., Perini, G., Parchem, R.J., Uribe, R.A., Barbieri, E. (2021) CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 8(19):e2005047
- Gao, X., Huang, S.S., Qiu, S.W., Su, Y., Wang, W.Q., Xu, H.Y., Xu, J.C., Kang, D.Y., Dai, P., Yuan, Y.Y. (2020) Congenital sensorineural hearing loss as the initial presentation of PTPN11-associated Noonan syndrome with multiple lentigines or Noonan syndrome: clinical features and underlying mechanisms. Journal of Medical Genetics. 58(7):465-474
- Ye, Z., Su, Z., Xie, S., Liu, Y., Wang, Y., Xu, X., Zheng, Y., Zhao, M., Jiang, L. (2020) Yap-lin28a axis targets let7-Wnt pathway to restore progenitors for initiating regeneration. eLIFE. 9:
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