Gene

thbs1b

ID
ZDB-GENE-020708-1
Name
thrombospondin 1b
Symbol
thbs1b Nomenclature History
Previous Names
  • thbs1
  • Tsp-1 (1)
  • si:dkey-11e23.1
  • wu:fc48c03
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable calcium ion binding activity and heparin binding activity. Predicted to be involved in negative regulation of angiogenesis. Predicted to act upstream of or within cell adhesion. Predicted to be located in cell surface; extracellular region; and sarcoplasmic reticulum. Predicted to be active in extracellular matrix. Is expressed in several structures, including cardiovascular system; head mesenchyme; nervous system; pectoral fin; and somite. Human ortholog(s) of this gene implicated in cholangiocarcinoma; pancreatic cancer; pancreatic ductal carcinoma; and primary open angle glaucoma. Orthologous to human THBS1 (thrombospondin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa1225Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-thbs1b
    Lin et al., 2025
    CRISPR2-thbs1b
      Lin et al., 2025
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      Human Disease
      Associated With thbs1b Human Ortholog
      No data available
      Associated With thbs1b Via Experimental Models
      No data available
      Gene Ontology
      Protein Domains
      Domain, Family, and Site Summary
      Type InterPro ID Name
      Domain IPR000742 EGF-like domain
      Domain IPR001007 VWFC domain
      Domain IPR001881 EGF-like calcium-binding domain
      Domain IPR008859 Thrombospondin, C-terminal
      Domain IPR048287 Thrombospondin-like, N-terminal domain
      1 - 5 of 11 Show all
      Domain Details Per Protein
      Protein Additional Resources Length Concanavalin A-like lectin/glucanase domain superfamily EGF-like calcium-binding domain EGF-like domain Thrombospondin, C-terminal Thrombospondin-like, N-terminal domain Thrombospondin type-1 (TSP1) repeat Thrombospondin type-1 (TSP1) repeat superfamily Thrombospondin, type 3-like repeat Thrombospondin, type 3 repeat TSP type-3 repeat VWFC domain
      UniProtKB:F1QEE7 InterPro 1170
      UniProtKB:F1QL35 InterPro 1171
      1 - 2 of 2
      Transcripts
      Genome Browsers
      Genome Build: GRCz11Chromosome: 20
      Type Name Annotation Method Has Havana Data Length (nt) Analysis
      mRNA thbs1b-201 (1) Ensembl 7,291 nt
      mRNA thbs1b-202 (1) Ensembl 5,303 nt
      mRNA thbs1b-204 (1) Ensembl 7,394 nt
      ncRNA thbs1b-002 (1) Ensembl 574 nt
      1 - 4 of 4
      Interactions and Pathways
      No data available
      Antibodies
      No data available
      Plasmids
      No data available
      Constructs
      No data available
      Marker Relationships
      Relationship Marker Type Marker Accession Numbers Citations
      Contained inBACDKEY-11E23ZFIN Curated Data
      EncodesESTfc48c03
      EncodesESTIMAGE:7157705Thisse et al., 2004
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      Sequences
      Orthology
      Comparative Orthology
      Alliance
      Gene Tree
      Ensembl
      Species Symbol Chromosome Accession # Evidence
      HumanTHBS115
      Conserved genome location (synteny) (1)
      Amino acid sequence comparison (1)
      MouseThbs12
      Amino acid sequence comparison (1)
      Conserved genome location (synteny) (1)
      Citations
      1 - 10 of 20
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