Gene
cpa5
- ID
- ZDB-GENE-020514-1
- Name
- carboxypeptidase A5
- Symbol
- cpa5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in blood; exocrine pancreas; liver; myeloid cell; and pancreas. Orthologous to several human genes including CPA1 (carboxypeptidase A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 38 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1060 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa38049 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Carboxypeptidase A, carboxypeptidase domain | Carboxypeptidase, activation peptide | Metallocarboxypeptidase-like, propeptide | Peptidase M14, carboxypeptidase A |
|---|---|---|---|---|---|---|
| UniProtKB:Q6PHV5 | InterPro | 419 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-92N2 | ZFIN Curated Data | |
| Encodes | EST | cb1060 | Thisse et al., 2001 | |
| Encodes | EST | fb68f03 | ||
| Encodes | cDNA | MGC:66011 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199271 (1) | 1360 nt | ||
| Genomic | GenBank:CT573397 (2) | 69590 nt | ||
| Polypeptide | UniProtKB:Q6PHV5 (1) | 419 aa |
- Chen, Z., He, M., Wang, H., Li, X., Qin, R., Ye, D., Zhai, X., Zhu, J., Zhang, Q., Hu, P., Shui, G., Sun, Y. (2024) Intestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally deposited yolk lipids. Nature communications. 15:97699769
- Prykhozhij, S.V., Ban, K., Brown, Z.L., Kobar, K., Wajnberg, G., Fuller, C., Chacko, S., Lacroix, J., Crapoulet, N., Midgen, C., Shlien, A., Malkin, D., Berman, J.N. (2024) miR-34a is a tumor suppressor in zebrafish and its expression levels impact metabolism, hematopoiesis and DNA damage. PLoS Genetics. 20:e1011290e1011290
- Sun, L., Yang, B., Peng, Z., Yang, T., Qin, B., Ao, J., Yang, Y., Wang, J., Zheng, L., Xie, H. (2023) Transcriptomics and Phenotypic Analysis of gpr56 Knockout in Zebrafish. International Journal of Molecular Sciences. 24(9):
- Biggs, C.M., Cordeiro-Santanach, A., Prykhozhij, S.V., Deveau, A.P., Lin, Y., Del Bel, K.L., Orben, F., Ragotte, R.J., Saferali, A., Mostafavi, S., Dinh, L., Dai, D., Weinacht, K.G., Dobbs, K., Ott de Bruin, L., Sharma, M., Tsai, K., Priatel, J.J., Schreiber, R.A., Rozmus, J., Hosking, M.C., Shopsowitz, K.E., McKinnon, M.L., Vercauteren, S., Seear, M., Notarangelo, L.D., Lynn, F.C., Berman, J.N., Turvey, S.E. (2022) Human JAK1 gain of function causes dysregulated myelopoeisis and severe allergic inflammation. JCI insight. 7(24):
- Ma, J., Shao, X., Geng, F., Liang, S., Yu, C., Zhang, R. (2022) Ercc2/Xpd deficiency results in failure of digestive organ growth in zebrafish with elevated nucleolar stress. iScience. 25:104957
- Shao, T., Ji, J.F., Zheng, J.Y., Li, C., Zhu, L.Y., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2022) Zbtb46 Controls Dendritic Cell Activation by Reprogramming Epigenetic Regulation of cd80/86 and cd40 Costimulatory Signals in a Zebrafish Model. Journal of immunology (Baltimore, Md. : 1950). 208(12):2686-2701
- Song, Y., Chen, W., Zhu, B., Ge, W. (2022) Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Frontiers in cell and developmental biology. 9:750888
- Tu, J., Yu, S., Li, J., Ren, M., Zhang, Y., Luo, J., Sun, K., Lv, Y., Han, Y., Huang, Y., Ren, X., Jiang, T., Tang, Z., Williams, M.T.S., Lu, Q., Liu, M. (2022) Dhx38 regulates the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Development (Cambridge, England). 149(17)
- Weeks, O., Miller, B.M., Pepe-Mooney, B.J., Oderberg, I.M., Freeburg, S.H., Smith, C.J., North, T.E., Goessling, W. (2022) Embryonic alcohol exposure disrupts the ubiquitin-proteasome system. JCI insight. 7(23):
- Yoon, B., Yeung, P., Santistevan, N., Bluhm, L., Kawasaki, K., Kueper, J., Dubielzig, R., Vanoudenhove, J., Cotney, J., Liao, E.C., Grinblat, Y. (2022) Zebrafish models of Alx-linked frontonasal dysplasia reveal a role for Alx1 and Alx3 in the anterior segment and vasculature of the developing eye. Biology Open. 11(5):
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