Gene

gbx2

ID
ZDB-GENE-020509-2
Name
gastrulation brain homeobox 2
Symbol
gbx2 Nomenclature History
Previous Names
  • gbx-2 (1)
  • fd07f12
  • wu:fd07f12 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within cerebellum development; iridophore differentiation; and telencephalon regionalization. Predicted to be active in nucleus. Is expressed in several structures, including midbrain hindbrain boundary neural keel; midbrain hindbrain boundary neural rod; midbrain neural rod; nervous system; and presumptive rhombomere 1. Orthologous to human GBX2 (gastrulation brain homeobox 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
40 figures from 23 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
e30Allele with one point mutationUnknownPremature StopENU
fh248Allele with one point mutationUnknownUnknownENU
fh253Allele with one point mutationUnknownPremature Stopnot specified
gbx2_unrecoveredAllele with one point mutationUnknownUnknownENU
mpn433TgTransgenic insertionUnknownUnknownDNA and CRISPR
sa40660Allele with one point mutationUnknownPremature StopENU
tud51TgTransgenic insertionUnknownUnknownDNA and CRISPR
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Sequence Targeting Reagents
1 - 4 of 4
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Human Disease
Associated With gbx2 Human Ortholog
No data available
Associated With gbx2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeodomain
Domain IPR020479 Homeodomain, metazoa
Family IPR042982 Homeobox protein GBX-1/2
Homologous_superfamily IPR009057 Homedomain-like superfamily
1 - 5 of 5
Domain Details Per Protein
Protein Additional Resources Length Homedomain-like superfamily Homeobox, conserved site Homeobox protein GBX-1/2 Homeodomain Homeodomain, metazoa
UniProtKB:Q8QGU1 InterPro 342
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 6
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA gbx2-201 (1) Ensembl 2,095 nt
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg1(gbx2-hsp70l:EGFP)
  • Danio rerio
1 (5)
Tg2(gbx2-hsp70l:EGFP)
  • Danio rerio
1 (3)
Tg3(gbx2-hsp70l:EGFP)
  • Danio rerio
1 (2)
Tg4(gbx2-hsp70l:EGFP)
  • Danio rerio
1 (3)
Tg(gbx2:Venus-NLS)
  • gbx2
  • Danio rerio
1Kesavan et al., 2020
Tg(hsp70l:gbx2)
  • gbx2
  • Danio rerio
1 (4)
Tg(mitfa:gbx2,EGFP)
  • Danio rerio
1Jang et al., 2021
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-30F11ZFIN Curated Data
EncodesESTfd07f12ZFIN Curated Data
EncodesESTmb2
    Rhinn et al., 2003
    EncodescDNAMGC:73023ZFIN Curated Data
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    Sequences
    Orthology
    Comparative Orthology
    Alliance
    Gene Tree
    Ensembl
    Species Symbol Chromosome Accession # Evidence
    HumanGBX22
    Conserved genome location (synteny) (3)
    Amino acid sequence comparison (4)
    MouseGbx21
    Amino acid sequence comparison (3)
    Conserved genome location (synteny) (1)
    Citations
    1 - 10 of 47
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