Gene
insrb
- ID
- ZDB-GENE-020503-4
- Name
- insulin receptor b
- Symbol
- insrb Nomenclature History
- Previous Names
-
- IRb (1)
- sb:eu666
- si:dkey-6n3.1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable insulin receptor activity and insulin receptor substrate binding activity. Acts upstream of or within with a positive effect on glycolytic process. Acts upstream of or within chordate embryonic development; developmental growth; and sprouting angiogenesis. Predicted to be located in membrane. Predicted to be part of insulin receptor complex. Predicted to be active in axon and plasma membrane. Is expressed in several structures, including endoderm; fertilized egg; immature eye; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Donohue syndrome; glucose metabolism disease (multiple); hepatocellular carcinoma; and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu666 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 20 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb358 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | TALEN | |
| la014143Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la014144Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028387Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028388Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa6697 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16909 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32383 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| xu0422Gt | Transgenic insertion | Unknown | Unknown | DNA |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Donohue syndrome | Alliance | Donohue syndrome | 246200 |
| familial hyperinsulinemic hypoglycemia 5 | Alliance | Hyperinsulinemic hypoglycemia, familial, 5 | 609968 |
| Diabetes mellitus, insulin-resistant, with acanthosis nigricans | 610549 | ||
| Rabson-Mendenhall syndrome | 262190 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR002011 | Tyrosine-protein kinase, receptor class II, conserved site |
| Domain | IPR000494 | Receptor L-domain |
| Domain | IPR000719 | Protein kinase domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Furin-like cysteine-rich domain | Furin-like repeat | Growth factor receptor cysteine-rich domain superfamily | Immunoglobulin-like fold | Insulin receptor, trans-membrane domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor L-domain | Receptor L-domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, insulin-like receptor | Tyrosine-protein kinase, receptor class II, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1LVG4 | InterPro | 1348 |
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Interactions and Pathways
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-6N3 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-38O13 | ZFIN Curated Data | |
| Encodes | EST | eu666 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001123229 (1) | 4047 nt | ||
| Genomic | GenBank:BX666064 (2) | 156234 nt | ||
| Polypeptide | UniProtKB:Q1LVG4 (1) | 1348 aa |
- Benchoula, K., Serpell, C.J., Mediani, A., Albogami, A., Misnan, N.M., Ismail, N.H., Parhar, I.S., Ogawa, S., Hwa, W.E. (2024) 1H NMR metabolomics insights into comparative diabesity in male and female zebrafish and the antidiabetic activity of DL-limonene. Scientific Reports. 14:38233823
- Chen, J., Zhao, W., Cao, L., Martins, R.S.T., Canário, A.V.M. (2024) Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish. BMC Biology. 22:163163
- Du, Q., Shao, R., Wang, W., Zhang, H., Liao, X., Wang, Z., Yin, Z., Ai, Q., Mai, K., Tang, X., Wan, M. (2024) Vitamin D3 Regulates Energy Homeostasis under Short-Term Fasting Condition in Zebrafish (Danio Rerio). Nutrients. 16(9):
- Wang, J.X., Zhang, Y.Y., Qian, Y.C., Qian, Y.F., Jin, A.H., Wang, M., Luo, Y., Qiao, F., Zhang, M.L., Chen, L.Q., Du, Z.Y. (2024) Inhibition of mitochondrial citrate shuttle alleviates metabolic syndromes induced by high-fat diet. American journal of physiology. Cell physiology. 327(3):C737-C749
- Antomagesh, F., Jayakumar Rajeswari, J., Vijayan, M.M. (2023) Chronic cortisol elevation restricts glucose uptake but not insulin responsiveness in zebrafish skeletal muscle. General and comparative endocrinology. 336:114231
- Qian, X., Klatt, S., Bennewitz, K., Wohlfart, D.P., Lou, B., Meng, Y., Buettner, M., Poschet, G., Morgenstern, J., Fleming, T., Sticht, C., Hausser, I., Fleming, I., Szendroedi, J., Nawroth, P.P., Kroll, J. (2023) Impaired Detoxification of Trans, Trans-2,4-Decadienal, an Oxidation Product from Omega-6 Fatty Acids, Alters Insulin Signaling, Gluconeogenesis and Promotes Microvascular Disease. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 11(4):e2302325
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) Deciphering the pathogenesis of retinopathy associated with carnitine palmitoyltransferase I deficiency in zebrafish model. Biochemical and Biophysical Research Communications. 664:100107100-107
- Xi, L., Zhai, G., Liu, Y., Gong, Y., Lu, Q., Zhang, Z., Liu, H., Jin, J., Zhu, X., Yin, Z., Xie, S., Han, D. (2023) Attenuated glucose uptake promotes catabolic metabolism through activated AMPK signaling and impaired insulin signaling in zebrafish. Frontiers in nutrition. 10:11872831187283
- Ding, Y., Lang, D., Yan, J., Bu, H., Li, H., Jiao, K., Yang, J., Ni, H., Morotti, S., Le, T., Clark, K.J., Port, J., Ekker, S.C., Cao, H., Zhang, Y., Wang, J., Grandi, E., Li, Z., Shi, Y., Li, Y., Glukhov, A.V., Xu, X. (2022) A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. eLIFE. 11:
- Höijer, I., Emmanouilidou, A., Östlund, R., van Schendel, R., Bozorgpana, S., Tijsterman, M., Feuk, L., Gyllensten, U., den Hoed, M., Ameur, A. (2022) CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations. Nature communications. 13:627
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