Gene

sec61a1a

ID
ZDB-GENE-020418-2
Name
SEC61 translocon subunit alpha 1a
Symbol
sec61a1a Nomenclature History
Previous Names
  • fb62c11
  • sec61a1
  • sec61a
  • sec61al1 (1)
  • chunp6898
  • wu:fb62c11 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to enable protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Involved in pronephric nephron development. Acts upstream of or within habenula development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of Sec61 translocon complex. Is expressed in several structures, including axis; digestive system; hatching gland; midbrain hindbrain boundary; and polster. Human ortholog(s) of this gene implicated in autosomal dominant tubulointerstitial kidney disease 5; common variable immunodeficiency; and severe congenital neutropenia. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
15 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
c163Allele with one point mutationExon 6Premature StopENU
hi1058TgTransgenic insertionIntron 1UnknownDNA
hi2839bTgTransgenic insertionIntron 1UnknownDNA
la011479TgTransgenic insertionUnknownUnknownDNA
sa31532Allele with one point mutationUnknownPremature StopENU
sa40755Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-sec61a1aN/A (2)
MO2-sec61a1aN/A (2)
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Human Disease
Associated With sec61a1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant tubulointerstitial kidney disease 5 Alliance Tubulointerstitial kidney disease, autosomal dominant, 5 617056
Immunodeficiency, common variable, 15 620670
?Neutropenia, severe congenital, 11, autosomal dominant 620674
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Associated With sec61a1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR030659 SecY conserved site
Domain IPR019561 Translocon Sec61/SecY, plug domain
Family IPR002208 SecY/SEC61-alpha family
Homologous_superfamily IPR023201 SecY domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length SecY conserved site SecY domain superfamily SecY/SEC61-alpha family Translocon Sec61/SecY, plug domain
UniProtKB:Q90ZM2 InterPro 476
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 6
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA sec61a1-201 (1) Ensembl 2,586 nt
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-197J19ZFIN Curated Data
EncodesESTfb62c11ZFIN Curated Data
EncodesESTIMAGE:6907835Thisse et al., 2004
EncodescDNAMGC:55256ZFIN Curated Data
EncodescDNAMGC:76848ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanSEC61A13
Amino acid sequence comparison (1)
MouseSec61a16
Amino acid sequence comparison (1)
Citations
1 - 10 of 17
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