Gene
il17rd
- ID
- ZDB-GENE-020320-5
- Name
- interleukin 17 receptor D
- Symbol
- il17rd Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable interleukin-17 receptor activity. Acts upstream of or within dorsal/ventral pattern formation; negative regulation of MAPK cascade; and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in membrane. Is expressed in several structures, including digestive system; mesoderm; nervous system; neural keel; and neural rod. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 18 with or without anosmia. Orthologous to human IL17RD (interleukin 17 receptor D).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 40 figures from 26 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb208 (65 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Aman et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la010872Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la010996Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la012050Tg | Transgenic insertion | Unknown | Unknown | DNA |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
hypogonadotropic hypogonadism 18 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 18 with or without anosmia | 615267 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Interleukin 17 receptor D, N-terminal | Interleukin-17 receptor-like | SEFIR domain |
---|---|---|---|---|---|
UniProtKB:A0A8M1PDW3 | InterPro | 745 | |||
UniProtKB:B3DKQ2 | InterPro | 744 | |||
UniProtKB:Q8QHJ9 | InterPro | 745 | |||
UniProtKB:A0A8M1P417 | InterPro | 742 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
il17rd-201
(1)
|
Ensembl | 2,984 nt | ||
mRNA |
il17rd-202
(1)
|
Ensembl | 6,340 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-174E22 | ZFIN Curated Data | |
Encodes | EST | cb208 | (2) | |
Encodes | EST | ibd2875 | ||
Encodes | EST | ibd5059 | ZFIN Curated Data | |
Encodes | cDNA | MGC:136328 | ZFIN Curated Data | |
Encodes | cDNA | MGC:195368 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_153660 (1) | 2976 nt | ||
Genomic | GenBank:CU459094 (1) | 78270 nt | ||
Polypeptide | UniProtKB:A0A8M1PDW3 (1) | 745 aa |
- Jung, J., Choi, I., Ro, H., Huh, T.L., Choe, J., Rhee, M. (2020) march5 Governs the Convergence and Extension Movement for Organization of the Telencephalon and Diencephalon in Zebrafish Embryos. Molecules and cells. 43(1):76-85
- Tsukiyama, T., Zou, J., Kim, J., Ogamino, S., Shino, Y., Masuda, T., Merenda, A., Matsumoto, M., Fujioka, Y., Hirose, T., Terai, S., Takahashi, H., Ishitani, T., Nakayama, K.I., Ohba, Y., Koo, B.K., Hatakeyama, S. (2020) A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis. Nature communications. 11:4586
- Kozlovskaja-Gumbrienė, A., Yi, R., Alexander, R., Aman, A., Jiskra, R., Nagelberg, D., Knaut, H., McClain, M., Piotrowski, T. (2017) Proliferation-independent regulation of organ size by Fgf/Notch signaling. eLIFE. 6
- Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
- Oksanen, K.E., Myllymäki, H., Ahava, M.J., Mäkinen, L., Parikka, M., Rämet, M. (2016) DNA Vaccination Boosts Bacillus Calmette-Guérin Protection against Mycobacterial Infection in Zebrafish. Developmental and comparative immunology. 54(1):89-96
- Venero Galanternik M., Lush, M.E., Piotrowski, T. (2016) Glypican4 Modulates Lateral Line Collective Cell Migration Non Cell-Autonomously. Developmental Biology. 419(2):321-335
- Felber, K., Elks, P.M., Lecca, M., Roehl, H.H. (2015) Expression of osterix Is Regulated by FGF and Wnt/β-Catenin Signalling during Osteoblast Differentiation. PLoS One. 10:e0144982
- Venero Galanternik, M., Kramer, K.L., Piotrowski, T. (2015) Heparan Sulfate Proteoglycans Regulate Fgf Signaling and Cell Polarity during Collective Cell Migration. Cell Reports. 10(30):414-428
- McGraw, H.F., Culbertson, M.D., Nechiporuk, A.V. (2014) Kremen1 restricts Dkk activity during posterior lateral line development in zebrafish. Development (Cambridge, England). 141(16):3212-21
- Sang, Q., Zhang, J., Feng, R., Wang, X., Li, Q., Zhao, X., Xing, Q., Chen, W., Du, J., Sun, S., Chai, R., Jin, L., He, L., Li, H., Wang, L. (2014) Ildr1b is essential for semicircular canal development, migration of the posterior lateral line primordium, and hearing ability in zebrafish: Implications for a role in the recessive hearing impairment DFNB42. Human molecular genetics. 23(23):6201-11
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