Gene
gria4a
- ID
- ZDB-GENE-020125-7
- Name
- glutamate receptor, ionotropic, AMPA 4a
- Symbol
- gria4a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Enables glutamate-gated receptor activity. Acts upstream of or within glial cell migration. Located in dendrite and neuronal cell body. Is expressed in nervous system. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human GRIA4 (glutamate ionotropic receptor AMPA type subunit 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 9 figures from Piller et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la019441Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa35998 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| uva43 | Allele with one insertion | Exon 6 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gria4a | Piller et al., 2021 | |
| CRISPR2-gria4a | Quint et al., 2023 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with or without seizures and gait abnormalities | 617864 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001320 | Ionotropic glutamate receptor, C-terminal |
| Domain | IPR001828 | Receptor, ligand binding region |
| Domain | IPR019594 | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain |
| Family | IPR001508 | Ionotropic glutamate receptor, metazoa |
| Family | IPR015683 | Ionotropic glutamate receptor |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Ionotropic glutamate receptor | Ionotropic glutamate receptor, C-terminal | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain | Ionotropic glutamate receptor, metazoa | Periplasmic binding protein-like I | Receptor, ligand binding region |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q71E59 | InterPro | 898 | ||||||
| UniProtKB:A0A8M9QLC3 | InterPro | 441 | ||||||
| UniProtKB:A0A8M6Z9L8 | InterPro | 898 | ||||||
| UniProtKB:A0A8M6Z4D2 | InterPro | 882 | ||||||
| UniProtKB:A0A8M6Z2V5 | InterPro | 882 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gria4a-201
(1)
|
Ensembl | 3,021 nt | ||
| mRNA |
gria4a-202
(1)
|
Ensembl | 1,407 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | ZFOS-1047B8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193824 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_214806 (1) | 3021 nt | ||
| Genomic | GenBank:FO704637 (1) | 41464 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z9L8 (1) | 898 aa |
- Quint, W.H., Tadema, K.C.D., Kokke, N.C.C.J., Meester-Smoor, M.A., Miller, A.C., Willemsen, R., Klaver, C.C.W., Iglesias, A.I. (2023) Post-GWAS screening of candidate genes for refractive error in mutant zebrafish models. Scientific Reports. 13:20172017
- Ikeda, A., Yamasaki, C., Kubo, Y., Doi, Y., Komamizu, M., Komatsu, M., Shiozaki, K. (2022) Alteration of the neuronal and glial cell profiles in Neu1-deficient zebrafish. Glycoconjugate journal. 39(4):499-512
- Buchumenski, I., Holler, K., Appelbaum, L., Eisenberg, E., Junker, J.P., Levanon, E.Y. (2021) Systematic identification of A-to-I RNA editing in zebrafish development and adult organs. Nucleic acids research. 49(8):4325-4337
- Piller, M., Werkman, I.L., Brown, E.A., Latimer, A.J., Kucenas, S. (2021) Glutamate signaling via the AMPAR subunit GluR4 regulates oligodendrocyte progenitor cell migration in the developing spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(25):5353-5371
- Maugars, G., Nourizadeh-Lillabadi, R., Weltzien, F.A. (2020) New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. Frontiers in endocrinology. 11:538196
- Naderi, M., Salahinejad, A., Attaran, A., Chivers, D.P., Niyogi, S. (2020) Chronic exposure to environmentally relevant concentrations of bisphenol S differentially affects cognitive behaviors in adult female zebrafish. Environmental pollution (Barking, Essex : 1987). 261:114060
- Naderi, M., Salahinejad, A., Attaran, A., Niyogi, S., Chivers, D.P. (2020) Rapid effects of estradiol and its receptors on object recognition and object placement in adult male zebrafish. Behavioural brain research. 384:112514
- Nakajo, H., Chou, M.Y., Kinoshita, M., Appelbaum, L., Shimazaki, H., Tsuboi, T., Okamoto, H. (2020) Hunger Potentiates the Habenular Winner Pathway for Social Conflict by Orexin-Promoted Biased Alternative Splicing of the AMPA Receptor Gene. Cell Reports. 31:107790
- Probst, J., Kölker, S., Okun, J.G., Kumar, A., Gursky, E., Posset, R., Hoffmann, G.F., Peravali, R., Zielonka, M. (2020) Chronic hyperammonemia causes a hypoglutamatergic and hyperGABAergic metabolic state associated with neurobehavioral abnormalities in zebrafish larvae. Experimental neurology. 331:113330
- Li, H., Zhao, F., Cao, F., Teng, M., Yang, Y., Qiu, L. (2019) Mitochondrial dysfunction-based cardiotoxicity and neurotoxicity induced by pyraclostrobin in zebrafish larvae. Environmental pollution (Barking, Essex : 1987). 251:203-211
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