Gene
gria2b
- ID
- ZDB-GENE-020125-4
- Name
- glutamate receptor, ionotropic, AMPA 2b
- Symbol
- gria2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable AMPA glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in postsynaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in dendritic spine and postsynaptic density membrane. Is expressed in central nervous system; retinal neural layer; and sensory neurons. Orthologous to human GRIA2 (glutamate ionotropic receptor AMPA type subunit 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu2571 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa1498 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa10318 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22520 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35727 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39009 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42424 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU | |
| sa44813 | Allele with one point mutation | Unknown | Unknown | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with language impairment and behavioral abnormalities | 618917 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001320 | Ionotropic glutamate receptor, C-terminal |
| Domain | IPR001828 | Receptor, ligand binding region |
| Domain | IPR019594 | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain |
| Family | IPR001508 | Ionotropic glutamate receptor, metazoa |
| Family | IPR015683 | Ionotropic glutamate receptor |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Ionotropic glutamate receptor | Ionotropic glutamate receptor, C-terminal | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain | Ionotropic glutamate receptor, metazoa | Periplasmic binding protein-like I | Receptor, ligand binding region |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q71E62 | InterPro | 879 | ||||||
| UniProtKB:A0A286YAM5 | InterPro | 897 | ||||||
| UniProtKB:A0A140LG34 | InterPro | 879 | ||||||
| UniProtKB:F1QKT1 | InterPro | 897 | ||||||
| UniProtKB:A0AB32T3X4 | InterPro | 807 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gria2b-201
(1)
|
Ensembl | 4,505 nt | ||
| mRNA |
gria2b-202
(1)
|
Ensembl | 3,011 nt | ||
| mRNA |
gria2b-205
(1)
|
Ensembl | 2,724 nt | ||
| mRNA |
gria2b-206
(1)
|
Ensembl | 446 nt | ||
| mRNA |
gria2b-207
(1)
|
Ensembl | 4,618 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-5I20 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-37G16 | ZFIN Curated Data | |
| Encodes | EST | eu643 | Thisse et al., 2005 | |
| Encodes | EST | eu924 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131895 (1) | 3736 nt | ||
| Genomic | GenBank:CT009687 (2) | 189137 nt | ||
| Polypeptide | UniProtKB:A0AB32T5C3 (1) | 944 aa |
- Dhiman, P., Kumar, R., Singh, D. (2025) Neuronal nitric oxide synthase activation by tadalafil protects neurological impairments in a zebrafish larva model of hyperammonemia. Life sciences. 361:123325123325
- Guo, J., Zou, Z., Dou, X., Zhao, X., Wang, Y., Wei, L., Pi, Y., Wang, Y., He, C., Guo, S. (2024) Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior. Nucleic acids research. 52(8):4257-4275
- Ikeda, A., Yamasaki, C., Kubo, Y., Doi, Y., Komamizu, M., Komatsu, M., Shiozaki, K. (2022) Alteration of the neuronal and glial cell profiles in Neu1-deficient zebrafish. Glycoconjugate journal. 39(4):499-512
- Shi, Z., Liang, X., Zhao, Y., Liu, W., Martyniuk, C.J. (2022) Neurotoxic effects of synthetic phenolic antioxidants on dopaminergic, serotoninergic, and GABAergic signaling in larval zebrafish (Danio rerio). The Science of the total environment. 830:154688
- Varela, T., Varela, D., Martins, G., Conceição, N., Cancela, M.L. (2022) Cdkl5 mutant zebrafish shows skeletal and neuronal alterations mimicking human CDKL5 deficiency disorder. Scientific Reports. 12:9325
- Buchumenski, I., Holler, K., Appelbaum, L., Eisenberg, E., Junker, J.P., Levanon, E.Y. (2021) Systematic identification of A-to-I RNA editing in zebrafish development and adult organs. Nucleic acids research. 49(8):4325-4337
- Liu, C., Wang, Y., Deng, J., Lin, J., Hu, C., Li, Q., Xu, X. (2021) Social Deficits and Repetitive Behaviors Are Improved by Early Postnatal Low-Dose VPA Intervention in a Novel shank3-Deficient Zebrafish Model. Frontiers in neuroscience. 15:682054
- Okamoto, H., Cherng, B.W., Nakajo, H., Chou, M.Y., Kinoshita, M. (2021) Habenula as the experience-dependent controlling switchboard of behavior and attention in social conflict and learning. Current opinion in neurobiology. 68:36-43
- Piller, M., Werkman, I.L., Brown, E.A., Latimer, A.J., Kucenas, S. (2021) Glutamate signaling via the AMPAR subunit GluR4 regulates oligodendrocyte progenitor cell migration in the developing spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(25):5353-5371
- Cao, Z., Su, M., Wang, H., Zhou, L., Meng, Z., Xiong, G., Liao, X., Lu, H. (2020) Carboxyl graphene oxide nanoparticles induce neurodevelopmental defects and locomotor disorders in zebrafish larvae. Chemosphere. 270:128611
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