Gene
meis1a
- ID
- ZDB-GENE-020122-3
- Name
- Meis homeobox 1 a
- Symbol
- meis1a Nomenclature History
- Previous Names
-
- meis4.1a
- meis4.1b
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific. Acts upstream of or within brain development. Predicted to be located in nucleus. Is expressed in several structures, including digestive system; nervous system; pectoral fin bud; pectoral fin musculature; and segmental plate. Orthologous to human MEIS1 (Meis homeobox 1).
- Genome Resources
- Note
-
meis4.1b was merged into meis4.1a because they were splice variants of the same gene according to the original publication by Waskiewicz et al., 2001.
- Comparative Information
-
- All Expression Data
- 10 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65739 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
iem1 | Allele with one delins | Donor Splice Site | Unknown | CRISPR | |
la021291Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la028180Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa16771 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa25673 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa44514 | Allele with one point mutation | Unknown | Unknown | ENU | |
sa45085 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
zko1001a | Allele with one deletion | Unknown | Unknown | CRISPR | |
zko1001b | Allele with one deletion | Unknown | Unknown | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-meis1a | (2) | |
CRISPR2-meis1a | Psutkova et al., 2024 | |
MO1-meis1 | N/A | Schulte et al., 2014 |
MO1-meis1a | N/A | Bessa et al., 2008 |
MO2-meis1 | N/A | (2) |
MO2-meis1a | N/A | Melvin et al., 2013 |
MO3-meis1a | N/A | Amin et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox protein PKNOX/Meis, N-terminal | Homeodomain | KN homeodomain | Three Amino acid Loop Extension (TALE) homeobox |
---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2B7B4 | InterPro | 379 | |||||
UniProtKB:Q7SZP3 | InterPro | 380 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
meis1a-201
(1)
|
Ensembl | 2,185 nt | ||
mRNA |
meis1a-203
(1)
|
Ensembl | 760 nt | ||
mRNA |
meis1a-204
(1)
|
Ensembl | 942 nt | ||
ncRNA |
meis1a-003
(1)
|
Ensembl | 933 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-212H16 | ZFIN Curated Data | |
Contained in | BAC | DKEY-202B17 | ZFIN Curated Data | |
Encodes | cDNA | MGC:65739 | ZFIN Curated Data | |
Encodes | cDNA | MGC:76814 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131897 (1) | 2178 nt | ||
Genomic | GenBank:BX547996 (1) | 213398 nt | ||
Polypeptide | UniProtKB:Q7SZP3 (1) | 380 aa |
- Psutkova, V., Nickl, P., Brezinova, V., Machonova, O., Machon, O. (2024) Transcription factor Meis1b regulates craniofacial morphogenesis in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 254(1):40-60
- Pradhan, S.J., Reddy, P.C., Smutny, M., Sharma, A., Sako, K., Oak, M.S., Shah, R., Pal, M., Deshpande, O., Dsilva, G., Tang, Y., Mishra, R., Deshpande, G., Giraldez, A.J., Sonawane, M., Heisenberg, C.P., Galande, S. (2021) Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis. Nature communications. 12:6094
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Ghosh, P., Maurer, J.M., Sagerström, C.G. (2018) Analysis of novel caudal hindbrain genes reveals different regulatory logic for gene expression in rhombomere 4 versus 5/6 in embryonic zebrafish. Neural Development. 13:13
- Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
- Macaulay, I.C., Svensson, V., Labalette, C., Ferreira, L., Hamey, F., Voet, T., Teichmann, S.A., Cvejic, A. (2016) Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells. Cell Reports. 14(4):966-77
- Xiao, C., Gao, L., Hou, Y., Xu, C., Chang, N., Wang, F., Hu, K., He, A., Luo, Y., Wang, J., Peng, J., Tang, F., Zhu, X., Xiong, J.W. (2016) Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish. Nature communications. 7:13787
- Amin, S., Donaldson, I.J., Zannino, D.A., Hensman, J., Rattray, M., Losa, M., Spitz, F., Ladam, F., Sagerström, C., Bobola, N. (2015) Hoxa2 selectively enhances Meis binding to change a branchial arch ground state. Developmental Cell. 32:265-77
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Schulte, E.C., Kousi, M., Tan, P.L., Tilch, E., Knauf, F., Lichtner, P., Trenkwalder, C., Högl, B., Frauscher, B., Berger, K., Fietze, I., Hornyak, M., Oertel, W.H., Bachmann, C.G., Zimprich, A., Peters, A., Gieger, C., Meitinger, T., Müller-Myhsok, B., Katsanis, N., Winkelmann, J. (2014) Targeted resequencing and systematic in vivo functional testing identifies rare variants in MEIS1 as significant contributors to restless legs syndrome. American journal of human genetics. 95:85-95
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