Gene
meis2a
- ID
- ZDB-GENE-020122-2
- Name
- Meis homeobox 2a
- Symbol
- meis2a Nomenclature History
- Previous Names
-
- meis2.2
- fa26d08
- wu:fa26d08 (1)
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific. Acts upstream of or within embryonic viscerocranium morphogenesis. Predicted to be located in nucleus. Is expressed in several structures, including anterior neural keel; hindbrain neural keel; nervous system; neural plate; and neural rod. Human ortholog(s) of this gene implicated in cleft palate; cleft palate, cardiac defects, and intellectual disability; learning disability; open-angle glaucoma; and orofacial cleft. Orthologous to human MEIS2 (Meis homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu315 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Melvin et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| iem3 | Allele with one deletion | Exon 2 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-meis2a | Psutkova et al., 2024 | |
| MO1-meis2a | N/A | Bessa et al., 2008 |
| MO2-meis2a | N/A | Ebarasi et al., 2009 |
| MO3-meis2a | N/A | Melvin et al., 2013 |
| MO4-meis2a | N/A | Amin et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cleft palate, cardiac defects, and intellectual disability | Alliance | Cleft palate, cardiac defects, and impaired intellectual development | 600987 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox protein PKNOX/Meis, N-terminal | Homeodomain | KN homeodomain | Three Amino acid Loop Extension (TALE) homeobox |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AJB0 | InterPro | 402 | |||||
| UniProtKB:A0A8M3B2P5 | InterPro | 396 | |||||
| UniProtKB:A0A0H2UKR5 | InterPro | 390 | |||||
| UniProtKB:A0A8M3AUM6 | InterPro | 389 | |||||
| UniProtKB:A0A8M3AUL9 | InterPro | 408 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
meis2a-201
(1)
|
Ensembl | 1,299 nt | ||
| mRNA |
meis2a-202
(1)
|
Ensembl | 581 nt | ||
| mRNA |
meis2a-203
(1)
|
Ensembl | 3,169 nt | ||
| mRNA |
meis2a-205
(1)
|
Ensembl | 1,221 nt | ||
| mRNA |
meis2a-206
(1)
|
Ensembl | 2,783 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-425J19 | ZFIN Curated Data | |
| Encodes | EST | eu315 | Thisse et al., 2005 | |
| Encodes | EST | fa26d08 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65757 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:76847 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131896 (1) | 2802 nt | ||
| Genomic | GenBank:CU467629 (2) | 29394 nt | ||
| Polypeptide | UniProtKB:A0A8M3AK57 (1) | 409 aa |
- Park, S.J., Silic, M.R., Staab, P.L., Chen, J., Zackschewski, E.L., Zhang, G. (2024) Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(8):722-749
- Psutkova, V., Nickl, P., Brezinova, V., Machonova, O., Machon, O. (2024) Transcription factor Meis1b regulates craniofacial morphogenesis in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 254(1):40-60
- Dai, Y.T., Zhang, F., Fang, H., Li, J.F., Lu, G., Jiang, L., Chen, B., Mao, D.D., Liu, Y.F., Wang, J., Peng, L.J., Feng, C., Chen, H.F., Mu, J.X., Zhang, Q.L., Wang, H., Ariffin, H., Moy, T.A., Wang, J.H., Lou, Y.J., Chen, S.N., Wang, Q., Liu, H., Shan, Z., Matsumura, I., Miyazaki, Y., Yasuda, T., Dou, L.P., Yan, X.J., Yan, J.S., Yeoh, A.E., Wu, D.P., Kiyoi, H., Hayakawa, F., Jin, J., Wang, S.Y., Sun, X.J., Mi, J.Q., Chen, Z., Huang, J.Y., Chen, S.J. (2022) Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases. Proceedings of the National Academy of Sciences of the United States of America. 119:e2120787119
- Jin, M., Zhang, H., Xu, B., Li, Y., Qin, H., Yu, S., He, J. (2022) Jag2b-Notch3/1b-mediated neuron-to-glia crosstalk controls retinal gliogenesis. EMBO reports. 23(10):e54922
- Kaaij, L.J., Mokry, M., Zhou, M., Musheev, M., Geeven, G., Melquiond, A.S., de Jesus Domingues, A.M., de Laat, W., Niehrs, C., Smith, A.D., Ketting, R.F. (2016) Enhancers reside in a unique epigenetic environment during early zebrafish development. Genome biology. 17:146
- Xiao, C., Gao, L., Hou, Y., Xu, C., Chang, N., Wang, F., Hu, K., He, A., Luo, Y., Wang, J., Peng, J., Tang, F., Zhu, X., Xiong, J.W. (2016) Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish. Nature communications. 7:13787
- Amin, S., Donaldson, I.J., Zannino, D.A., Hensman, J., Rattray, M., Losa, M., Spitz, F., Ladam, F., Sagerström, C., Bobola, N. (2015) Hoxa2 selectively enhances Meis binding to change a branchial arch ground state. Developmental Cell. 32:265-77
- Samarut, E., Gaudin, C., Hughes, S., Gillet, B., de Bernard, S., Jouve, P.E., Buffat, L., Allot, A., Lecompte, O., Berekelya, L., Rochette-Egly, C., and Laudet, V. (2014) Retinoic acid receptor subtype-specific transcriptotypes in the early zebrafish embryo. Molecular endocrinology (Baltimore, Md.). 28(2):260-272
- Melvin, V.S., Feng, W., Hernandez-Lagunas, L., Artinger, K.B., and Williams, T. (2013) A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(7):817-31
- Miyake, A., and Itoh, N. (2013) Fgf22 regulated by Fgf3/Fgf8 signaling is required for zebrafish midbrain development. Biology Open. 2(5):515-524
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