Gene
gbx1
- ID
- ZDB-GENE-020117-2
- Name
- gastrulation brain homeobox 1
- Symbol
- gbx1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior pattern specification; cerebellum development; and regulation of canonical Wnt signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including nervous system; neural keel; neural plate; presumptive neural plate; and ventral mesoderm. Orthologous to human GBX1 (gastrulation brain homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 39 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb619 (31 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Rhinn et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh271 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| gbx1_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU | |
| tud48Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| um300 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| um301 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gbx1 | Ghosh et al., 2018 | |
| CRISPR2-gbx1 | Kesavan et al., 2020 | |
| CRISPR3-gbx1 | Zhao et al., 2024 | |
| MO1-gbx1 | N/A | Rhinn et al., 2009 |
| MO2-gbx1 | N/A | Rhinn et al., 2009 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein GBX-1/2 | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q90ZB2 | InterPro | 316 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(gbx1:Venus) |
|
| 1 | Kesavan et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-89L23 | ZFIN Curated Data | |
| Encodes | EST | cb619 | Thisse et al., 2001 | |
| Encodes | EST | fj77a06 | ZFIN Curated Data | |
| Encodes | EST | mb1 | Rhinn et al., 2003 | |
| Encodes | cDNA | MGC:194383 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194384 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_174861 (1) | 1837 nt | ||
| Genomic | GenBank:CT583690 (2) | 110045 nt | ||
| Polypeptide | UniProtKB:Q90ZB2 (1) | 316 aa |
- Zhao, S., Wang, C., Luo, H., Li, F., Wang, Q., Xu, J., Huang, Z., Liu, W., Zhang, W. (2024) A role for Retinoblastoma 1 in hindbrain morphogenesis by regulating GBX family. Journal of genetics and genomics = Yi chuan xue bao. 51(9):900-910
- Silva, N., Campinho, M.A. (2023) In a zebrafish biomedical model of human Allan-Herndon-Dudley syndrome impaired MTH signaling leads to decreased neural cell diversity. Frontiers in endocrinology. 14:11576851157685
- Brunt, L., Greicius, G., Rogers, S., Evans, B.D., Virshup, D.M., Wedgwood, K.C.A., Scholpp, S. (2021) Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling. Nature communications. 12:2058
- Green, D.G., Whitener, A.E., Mohanty, S., Mistretta, B., Gunaratne, P., Yeh, A.T., Lekven, A.C. (2020) Wnt signaling regulates neural plate patterning in distinct temporal phases with dynamic transcriptional outputs. Developmental Biology. 462(2):152-164
- Kesavan, G., Machate, A., Hans, S., Brand, M. (2020) Cell-fate plasticity, adhesion and cell sorting complementarily establish a sharp midbrain-hindbrain boundary. Development (Cambridge, England). 147(11):
- Tuazon, F.B., Wang, X., Andrade, J.L., Umulis, D., Mullins, M.C. (2020) Proteolytic Restriction of Chordin Range Underlies BMP Gradient Formation. Cell Reports. 32:108039
- Ghosh, P., Maurer, J.M., Sagerström, C.G. (2018) Analysis of novel caudal hindbrain genes reveals different regulatory logic for gene expression in rhombomere 4 versus 5/6 in embryonic zebrafish. Neural Development. 13:13
- Wang, Z., Nakayama, Y., Tsuda, S., Yamasu, K. (2018) The role of gastrulation brain homeobox 2 (gbx2) in the development of the ventral telencephalon in zebrafish embryos. Differentiation; research in biological diversity. 99:28-40
- Nakayama, Y., Inomata, C., Yuikawa, T., Tsuda, S., Yamasu, K. (2017) Comprehensive analysis of target genes in zebrafish embryos reveals gbx2 involvement in neurogenesis. Developmental Biology. 430(1):237-248
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
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