Gene
her9
- ID
- ZDB-GENE-011213-1
- Name
- hairy-related 9
- Symbol
- her9 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including bone mineralization; neuronal stem cell population maintenance; and photoreceptor cell maintenance. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; digestive system; neural plate; pronephros; and retina. Orthologous to human HES4 (hes family bHLH transcription factor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 46 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| co66 | Allele with one point mutation | Exon 4 | Premature Stop | ENU | |
| la011036Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa43978 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| uky2 | Allele with one insertion | Unknown | Frameshift, Premature Stop | CRISPR | |
| uky3 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Hairy and Enhancer of Split/HEY-related | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Orange domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B8Z8 | InterPro | 290 | ||||
| UniProtKB:Q9DF41 | InterPro | 291 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-27M6 | ZFIN Curated Data | |
| Encodes | EST | fc30a03 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:100766 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174858 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131873 (1) | 1448 nt | ||
| Genomic | GenBank:CR751236 (2) | 108342 nt | ||
| Polypeptide | UniProtKB:Q9DF41 (1) | 291 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Chen, Y.C., Hsieh, F.Y., Chang, C.W., Sun, M.Q., Cheng, Y.C. (2024) Temporal and Spatial Variations in Zebrafish Hairy/E(spl) Gene Expression in Response to Mib1-Mediated Notch Signaling During Neurodevelopment. International Journal of Molecular Sciences. 25(17):
- Engel-Pizcueta, C., Hevia, C.F., Voltes, A., Livet, J., Pujades, C. (2024) Her9 controls the stemness properties of hindbrain boundary cells. Development (Cambridge, England). 152(1):
- Li, Y., Liu, C., Bai, X., Li, M., Duan, C. (2023) FK506-binding protein 5 regulates cell quiescence-proliferation decision in zebrafish epithelium. FEBS letters. 597(14):1868-1879
- Morales, R.A., Rabahi, S., Diaz, O.E., Salloum, Y., Kern, B.C., Westling, M., Luo, X., Parigi, S.M., Monasterio, G., Das, S., Hernández, P.P., Villablanca, E.J. (2022) Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine. Mucosal immunology. 15(5):940-951
- Sánchez-Iranzo, H., Halavatyi, A., Diz-Muñoz, A. (2022) Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord. eLIFE. 11:
- Soto, X., Burton, J., Manning, C.S., Minchington, T., Lea, R., Lee, J., Kursawe, J., Rattray, M., Papalopulu, N. (2022) Sequential and additive expression of miR-9 precursors control timing of neurogenesis. Development (Cambridge, England). 149(19):
- Stenzel, A., Mumme-Monheit, A., Sucharov, J., Walker, M., Mitchell, J.M., Appel, B., Nichols, J.T. (2022) Distinct and redundant roles for zebrafish her genes during mineralization and craniofacial patterning. Frontiers in endocrinology. 13:10338431033843
- Kuretani, A., Yamamoto, T., Taira, M., Michiue, T. (2021) Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. BMC ecology and evolution. 21:147
- Yuikawa, T., Ikeda, M., Tsuda, S., Saito, S., Yamasu, K. (2021) Involvement of Oct4-type transcription factor Pou5f3 in posterior spinal cord formation in zebrafish embryos. Development, growth & differentiation. 63(6):306-322
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