Gene
mt-cyb
- ID
- ZDB-GENE-011205-17
- Name
- cytochrome b, mitochondrial
- Symbol
- mt-cyb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: MT Mapping Details/Browsers
- Description
- Predicted to enable electron transfer activity; metal ion binding activity; and oxidoreductase activity. Predicted to contribute to quinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Predicted to act upstream of or within respiratory electron transport chain. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex III. Predicted to be active in membrane. Is expressed in brain; liver; male organism; and muscle. Human ortholog(s) of this gene implicated in ovarian carcinoma and urinary bladder cancer. Orthologous to human MT-CYB (mitochondrially encoded cytochrome b).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005797 | Cytochrome b/b6, N-terminal domain |
| Domain | IPR005798 | Cytochrome b/b6, C-terminal |
| Domain | IPR048259 | Cytochrome b/b6, N-terminal domain, eukaryotic/bacterial |
| Domain | IPR048260 | Cytochrome b/b6, C-terminal domain, eukaryotic/bacterial |
| Family | IPR030689 | Cytochrome b |
1 - 5 of 8 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome b | Cytochrome b/b6, C-terminal | Cytochrome b/b6, C-terminal domain, eukaryotic/bacterial | Cytochrome b/b6, C-terminal domain superfamily | Cytochrome b/b6-like domain superfamily | Cytochrome b/b6, N-terminal domain | Cytochrome b/b6, N-terminal domain, eukaryotic/bacterial | Di-haem cytochrome, transmembrane |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0A0VDB5 | InterPro | 380 |
1 - 1 of 1
- Genome Browsers
- No data available
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mt-cyb-201
(1)
|
Ensembl | 1,141 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
- Lin, J., Li, X., Lu, K., Song, K., Wang, L., Dai, W., Mohamed, M., Zhang, C. (2024) Low phosphorus causes hepatic energy metabolism disorder through Dynamin-related protein 1-mediated mitochondrial fission in fish. The Journal of nutrition. 155(1):132-152
- Wang, J.X., Zhang, Y.Y., Qian, Y.C., Qian, Y.F., Jin, A.H., Wang, M., Luo, Y., Qiao, F., Zhang, M.L., Chen, L.Q., Du, Z.Y. (2024) Inhibition of mitochondrial citrate shuttle alleviates metabolic syndromes induced by high-fat diet. American journal of physiology. Cell physiology. 327(3):C737-C749
- Shi, L., Zhang, A., Liu, H., Wang, H. (2023) Deletion of the foxO4 Gene Increases Hypoxia Tolerance in Zebrafish. International Journal of Molecular Sciences. 24(10):
- Van Haute, L., O'Connor, E., Díaz-Maldonado, H., Munro, B., Polavarapu, K., Hock, D.H., Arunachal, G., Athanasiou-Fragkouli, A., Bardhan, M., Barth, M., Bonneau, D., Brunetti-Pierri, N., Cappuccio, G., Caruana, N.J., Dominik, N., Goel, H., Helman, G., Houlden, H., Lenaers, G., Mention, K., Murphy, D., Nandeesh, B., Olimpio, C., Powell, C.A., Preethish-Kumar, V., Procaccio, V., Rius, R., Rebelo-Guiomar, P., Simons, C., Vengalil, S., Zaki, M.S., Ziegler, A., Thorburn, D.R., Stroud, D.A., Maroofian, R., Christodoulou, J., Gustafsson, C., Nalini, A., Lochmüller, H., Minczuk, M., Horvath, R. (2023) TEFM variants impair mitochondrial transcription causing childhood-onset neurological disease. Nature communications. 14:10091009
- Liu, H., Chen, Y., Hu, W., Luo, Y., Zhu, P., You, S., Li, Y., Jiang, Z., Wu, X., Li, X. (2022) Impacts of PFOAC8, GenXC6, and their mixtures on zebrafish developmental toxicity and gene expression provide insight about tumor-related disease. The Science of the total environment. 858(Pt 2):160085
- Sabharwal, A., Wishman, M.D., Cervera, R.L., Serres, M.R., Anderson, J.L., Holmberg, S.R., Kar, B., Treichel, A.J., Ichino, N., Liu, W., Yang, J., Ding, Y., Deng, Y., Lacey, J.M., Laxen, W.J., Loken, P.R., Oglesbee, D., Farber, S.A., Clark, K.J., Xu, X., Ekker, S.C. (2022) Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality. eLIFE. 11:
- Song, Y., Chen, W., Zhu, B., Ge, W. (2022) Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Frontiers in cell and developmental biology. 9:750888
- Tian, J., Du, Y., Yu, E., Lei, C., Xia, Y., Jiang, P., Li, H., Zhang, K., Li, Z., Gong, W., Xie, J., Wang, G. (2022) Prostaglandin 2α Promotes Autophagy and Mitochondrial Energy Production in Fish Hepatocytes. Cells. 11(12)
- Dong, N., Bandura, J., Zhang, Z., Wang, Y., Labadie, K., Noel, B., Davison, A., Koene, J.M., Sun, H.S., Coutellec, M.A., Feng, Z.P. (2021) Ion channel profiling of the Lymnaea stagnalis ganglia via transcriptome analysis. BMC Genomics. 22:18
- Han, S.L., Qian, Y.C., Limbu, S.M., Wang, J., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2021) Lipolysis and lipophagy play individual and interactive roles in regulating triacylglycerol and cholesterol homeostasis and mitochondrial form in zebrafish. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1866(9):158988
1 - 10 of 41
Show