Gene
mt-co1
- ID
- ZDB-GENE-011205-14
- Name
- cytochrome c oxidase I, mitochondrial
- Symbol
- mt-co1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: MT Mapping Details/Browsers
- Description
- Predicted to enable several functions, including copper ion binding activity; heme binding activity; and oxidoreduction-driven active transmembrane transporter activity. Predicted to contribute to cytochrome-c oxidase activity. Acts upstream of or within response to cadmium ion and response to methylmercury. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Is expressed in several structures, including female organism; gill; liver; male organism; and musculature system. Orthologous to human MT-CO1 (mitochondrially encoded cytochrome c oxidase I).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR023615 | Cytochrome c oxidase, subunit I, copper-binding site |
| Domain | IPR023616 | Cytochrome c oxidase-like, subunit I domain |
| Domain | IPR033944 | Cytochrome c oxidase subunit I domain |
| Family | IPR000883 | Cytochrome c oxidase subunit I |
| Homologous_superfamily | IPR036927 | Cytochrome c oxidase-like, subunit I superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome c oxidase-like, subunit I domain | Cytochrome c oxidase-like, subunit I superfamily | Cytochrome c oxidase subunit I | Cytochrome c oxidase, subunit I, copper-binding site | Cytochrome c oxidase subunit I domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q9MIY8 | InterPro | 516 | |||||
| UniProtKB:A0A0A0VG02 | InterPro | 516 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mt-co1-201
(1)
|
Ensembl | 1,551 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
- She, P., Gao, B., Li, D., Wu, C., Zhu, X., He, Y., Mo, F., Qi, Y., Jin, D., Chen, Y., Zhao, X., Lin, J., Hu, H., Li, J., Zhang, B., Xie, P., Lin, C., Christoffels, V.M., Wu, Y., Zhu, P., Zhong, T.P. (2025) The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis. Nature communications. 16:232232
- Wang, H., Siren, J., Perttunen, S., Immonen, K., Chen, Y.C., Narumanchi, S., Kosonen, R., Paavola, J., Laine, M., Tikkanen, I., Lakkisto, P. (2024) Deficiency of heme oxygenase 1a causes detrimental effects on cardiac function. Journal of Cellular and Molecular Medicine. 28:e18243e18243
- Moraes, I.B., Paiva, I.M., Moreira-Júnior, R.E., Sartori, B.M., Franco, R.R., Espindola, F.S., Murgas, L.D.S., Brunialti-Godard, A.L. (2023) Ethanol Preference Leads to Alterations in Telomere Length, Mitochondria Copy Number, and Antioxidant Enzyme Activity in Zebrafish Brains. Frontiers in bioscience (Landmark edition). 28:7373
- Shi, L., Zhang, A., Liu, H., Wang, H. (2023) Deletion of the foxO4 Gene Increases Hypoxia Tolerance in Zebrafish. International Journal of Molecular Sciences. 24(10):
- Van Haute, L., O'Connor, E., Díaz-Maldonado, H., Munro, B., Polavarapu, K., Hock, D.H., Arunachal, G., Athanasiou-Fragkouli, A., Bardhan, M., Barth, M., Bonneau, D., Brunetti-Pierri, N., Cappuccio, G., Caruana, N.J., Dominik, N., Goel, H., Helman, G., Houlden, H., Lenaers, G., Mention, K., Murphy, D., Nandeesh, B., Olimpio, C., Powell, C.A., Preethish-Kumar, V., Procaccio, V., Rius, R., Rebelo-Guiomar, P., Simons, C., Vengalil, S., Zaki, M.S., Ziegler, A., Thorburn, D.R., Stroud, D.A., Maroofian, R., Christodoulou, J., Gustafsson, C., Nalini, A., Lochmüller, H., Minczuk, M., Horvath, R. (2023) TEFM variants impair mitochondrial transcription causing childhood-onset neurological disease. Nature communications. 14:10091009
- Cacialli, P., Mailhe, M.P., Wagner, I., Merkler, D., Golub, R., Bertrand, J.Y. (2022) Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates. The EMBO journal. 41(19):e108536
- Ivantsova, E., Wengrovitz, A.S., Souders, C.L., Martyniuk, C.J. (2022) Developmental and behavioral toxicity assessment of glyphosate and its main metabolite aminomethylphosphonic acid (AMPA) in zebrafish embryos/larvae. Environmental Toxicology and Pharmacology. 93:103873
- Sabharwal, A., Wishman, M.D., Cervera, R.L., Serres, M.R., Anderson, J.L., Holmberg, S.R., Kar, B., Treichel, A.J., Ichino, N., Liu, W., Yang, J., Ding, Y., Deng, Y., Lacey, J.M., Laxen, W.J., Loken, P.R., Oglesbee, D., Farber, S.A., Clark, K.J., Xu, X., Ekker, S.C. (2022) Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality. eLIFE. 11:
- Song, Y., Chen, W., Zhu, B., Ge, W. (2022) Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Frontiers in cell and developmental biology. 9:750888
- Spelat, R., Ferro, F., Contessotto, P., Aljaabary, A., Martin-Saldaña, S., Jin, C., Karlsson, N.G., Grealy, M., Hilscher, M.M., Magni, F., Chinello, C., Kilcoyne, M., Pandit, A. (2022) Metabolic reprogramming and membrane glycan remodeling as potential drivers of zebrafish heart regeneration. Communications biology. 5:13651365
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