Gene
gpc4
- ID
- ZDB-GENE-011119-1
- Name
- glypican 4
- Symbol
- gpc4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Acts upstream of with a positive effect on lamellipodium organization; regulation of cell migration; and regulation of extracellular matrix assembly. Acts upstream of or within several processes, including gastrulation; post-anal tail morphogenesis; and skeletal system development. Predicted to be located in plasma membrane and side of membrane. Predicted to be active in cell surface and synapse. Is expressed in several structures, including axial chorda mesoderm; blastomere; lateral line system; quadrate-anguloarticular joint; and tail bud. Human ortholog(s) of this gene implicated in Keipert syndrome. Orthologous to human GPC4 (glypican 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 67 figures from 32 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b404 | unknown | Unknown | Unknown | g-rays | |
| b639 | unknown | Unknown | Unknown | ENU | |
| fr6 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| gpc4_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
| hi1688Tg | Transgenic insertion | Exon 4 | Unknown | DNA | |
| hi1934Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la012557Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| m119 | Allele with one point mutation | Unknown | Missense | ENU | |
| m818 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa9771 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-gpc4 | N/A | (2) |
| MO2-gpc4 | N/A | Shao et al., 2009 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Keipert syndrome | Alliance | Keipert syndrome | 301026 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001863 | Glypican |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Glypican |
|---|---|---|---|
| UniProtKB:B3DJ94 | InterPro | 557 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(sox17:GFP-gpc4) |
|
| 1 | Hu et al., 2021 | |
| Tg(sox17:GFP-gpc4-sdc4) |
| 1 | Hu et al., 2021 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-191O15 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-57B1 | ZFIN Curated Data | |
| Encodes | EST | fc47a08 | ||
| Encodes | EST | fe05f10 | ZFIN Curated Data | |
| Encodes | STS | chunp6920 | ||
| Encodes | cDNA | MGC:194854 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131860 (1) | 1822 nt | ||
| Genomic | GenBank:BX530080 (1) | 165220 nt | ||
| Polypeptide | UniProtKB:B3DJ94 (1) | 557 aa |
- Carroll, S.H., Schafer, S., Kawasaki, K., Tsimbal, C., Jule, A.M., Hallett, S.A., Li, E., Liao, E.C. (2024) Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis. eLIFE. 13:
- Dranow, D.B., Le Pabic, P., Schilling, T.F. (2023) The non-canonical Wnt receptor Ror2 is required for cartilage cell polarity and morphogenesis of the craniofacial skeleton in zebrafish. Development (Cambridge, England). 150(8):
- Balaraju, A.K., Hu, B., Rodriguez, J.J., Murry, M., Lin, F. (2021) Glypican 4 regulates planar cell polarity of endoderm cells by controlling the localization of Cadherin 2. Development (Cambridge, England). 148(14):
- Hu, B., Rodriguez, J.J., Kakkerla Balaraju, A., Gao, Y., Nguyen, N.T., Steen, H., Suhaib, S., Chen, S., Lin, F. (2021) Glypican 4 mediates Wnt transport between germ layers via signaling filopodia. The Journal of cell biology. 220(12):
- Keil, S., Gupta, M., Brand, M., Knopf, F. (2021) Heparan sulfate proteoglycan expression in the regenerating zebrafish fin. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(9):1368-1380
- Sidik, A., Dixon, G., Buckley, D.M., Kirby, H.G., Sun, S., Eberhart, J.K. (2021) Exposure to ethanol leads to midfacial hypoplasia in a zebrafish model of FASD via indirect interactions with the Shh pathway. BMC Biology. 19:134
- Xia, Z.J., Zeng, X.I., Tambe, M., Ng, B.G., Dong, P.D.S., Freeze, H.H. (2021) A Dominant Heterozygous Mutation in COG4 Causes Saul-Wilson Syndrome, a Primordial Dwarfism, and Disrupts Zebrafish Development via Wnt Signaling. Frontiers in cell and developmental biology. 9:720688
- Statzer, C., Ewald, C.Y. (2020) The extracellular matrix phenome across species. Matrix biology plus. 8:100039
- Williams, M.L.K., Solnica-Krezel, L. (2020) Nodal and Planar Cell Polarity signaling cooperate to regulate zebrafish convergence and extension gastrulation movements. eLIFE. 9:
- Navajas Acedo, J., Voas, M.G., Alexander, R., Woolley, T., Unruh, J.R., Li, H., Moens, C., Piotrowski, T. (2019) PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation. Nature communications. 10:3993
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