Gene

ugdh

ID
ZDB-GENE-011022-1
Name
UDP-glucose 6-dehydrogenase
Symbol
ugdh Nomenclature History
Previous Names
  • ik:tdsubc_2a8 (1)
  • jek
  • jekyll
  • sb:eu659
  • tdsubc_2a8
  • xx:tdsubc_2a8
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable NAD binding activity and UDP-glucose 6-dehydrogenase activity. Acts upstream of or within atrioventricular valve formation; determination of left/right symmetry; and positive regulation of signal transduction. Predicted to be active in nucleus. Is expressed in several structures, including axis; head; heart tube; mesoderm; and vestibuloauditory system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 84. Orthologous to human UGDH (UDP-glucose 6-dehydrogenase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
23 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
m151Allele with one point mutationUnknownMissenseENU
m310unknownUnknownUnknownENU
zko444aAllele with one deletionUnknownUnknownCRISPR
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-ugdh (2)
CRISPR2-ugdh (2)
MO1-ugdhN/A (2)
MO2-ugdhN/AHyde et al., 2012
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Human Disease
Associated With ugdh Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
developmental and epileptic encephalopathy 84 Alliance Developmental and epileptic encephalopathy 84 618792
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Associated With ugdh Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal
Domain IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation
Domain IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal
Family IPR017476 UDP-glucose/GDP-mannose dehydrogenase
Family IPR028356 UDP-glucose 6-dehydrogenase, eukaryotic type
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Domain Details Per Protein
Protein Additional Resources Length 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily NAD(P)-binding domain superfamily UDP-glucose 6-dehydrogenase, eukaryotic type UDP-glucose/GDP-mannose dehydrogenase UDP-glucose/GDP-mannose dehydrogenase, C-terminal UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily UDP-glucose/GDP-mannose dehydrogenase, dimerisation UDP-glucose/GDP-mannose dehydrogenase, N-terminal
UniProtKB:A8WGP7 InterPro 493
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 1
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ugdh-201 (1) Ensembl 2,589 nt
mRNA ugdh-202 (1) Ensembl 1,596 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanUGDH4
Functional complementation (1)
Amino acid sequence comparison (2)
Conserved genome location (synteny) (1)
MouseUgdh5
Amino acid sequence comparison (2)
Conserved genome location (synteny) (1)
Fruit flysgl3L
Amino acid sequence comparison (1)
Citations
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