Gene
ugdh
- ID
- ZDB-GENE-011022-1
- Name
- UDP-glucose 6-dehydrogenase
- Symbol
- ugdh Nomenclature History
- Previous Names
-
- ik:tdsubc_2a8 (1)
- jek
- jekyll
- sb:eu659
- tdsubc_2a8
- xx:tdsubc_2a8
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable NAD binding activity and UDP-glucose 6-dehydrogenase activity. Acts upstream of or within atrioventricular valve formation; determination of left/right symmetry; and positive regulation of signal transduction. Predicted to be active in nucleus. Is expressed in several structures, including axis; head; heart tube; mesoderm; and vestibuloauditory system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 84. Orthologous to human UGDH (UDP-glucose 6-dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu659 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 23 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ugdh | (2) | |
| CRISPR2-ugdh | (2) | |
| MO1-ugdh | N/A | (2) |
| MO2-ugdh | N/A | Hyde et al., 2012 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 84 | Alliance | Developmental and epileptic encephalopathy 84 | 618792 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001732 | UDP-glucose/GDP-mannose dehydrogenase, N-terminal |
| Domain | IPR014026 | UDP-glucose/GDP-mannose dehydrogenase, dimerisation |
| Domain | IPR014027 | UDP-glucose/GDP-mannose dehydrogenase, C-terminal |
| Family | IPR017476 | UDP-glucose/GDP-mannose dehydrogenase |
| Family | IPR028356 | UDP-glucose 6-dehydrogenase, eukaryotic type |
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Domain Details Per Protein
| Protein | Additional Resources | Length | 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily | NAD(P)-binding domain superfamily | UDP-glucose 6-dehydrogenase, eukaryotic type | UDP-glucose/GDP-mannose dehydrogenase | UDP-glucose/GDP-mannose dehydrogenase, C-terminal | UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily | UDP-glucose/GDP-mannose dehydrogenase, dimerisation | UDP-glucose/GDP-mannose dehydrogenase, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A8WGP7 | InterPro | 493 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-274K22 | ZFIN Curated Data | |
| Encodes | EST | eu659 | Thisse et al., 2005 | |
| Encodes | EST | tdsubc_2a8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174854 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194857 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194893 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001110402 (1) | 2247 nt | ||
| Genomic | GenBank:AL844559 (1) | 216608 nt | ||
| Polypeptide | UniProtKB:A8WGP7 (1) | 493 aa |
- Ren, M., Chen, X., Dai, L., Tu, J., Hu, H., Sun, X., Luo, J., Li, P., Fu, Y., Zhu, Y., Sun, W., Tang, Z., Liu, M., Ren, X., Lu, Q. (2024) Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish. Biomedicines. 13:
- Jones, A.A., Diamantopoulou, E., Baxendale, S., Whitfield, T.T. (2022) Presence of chondroitin sulphate and requirement for heparan sulphate biosynthesis in the developing zebrafish inner ear. Frontiers in cell and developmental biology. 10:959624
- Mackowetzky, K., Dicipulo, R., Fox, S.C., Philibert, D.A., Todesco, H., Doshi, J.D., Kawakami, K., Tierney, K., Waskiewicz, A.J. (2022) Retinoic Acid Signaling Regulates Late Stages of Semicircular Canal Morphogenesis and Otolith Maintenance in the Zebrafish Inner Ear. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(11):1798-1815
- Chen, X., Huang, Y., Gao, P., Lv, Y., Jia, D., Sun, K., Han, Y., Hu, H., Tang, Z., Ren, X., Liu, M. (2021) Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells. Biomedicines. 9(11):
- Munjal, A., Hannezo, E., Tsai, T.Y., Mitchison, T.J., Megason, S.G. (2021) Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis. Cell. 184:6313-6325.e18
- Hengel, H., Bosso-Lefèvre, C., Grady, G., Szenker-Ravi, E., Li, H., Pierce, S., Lebigot, É., Tan, T.T., Eio, M.Y., Narayanan, G., Utami, K.H., Yau, M., Handal, N., Deigendesch, W., Keimer, R., Marzouqa, H.M., Gunay-Aygun, M., Muriello, M.J., Verhelst, H., Weckhuysen, S., Mahida, S., Naidu, S., Thomas, T.G., Lim, J.Y., Tan, E.S., Haye, D., Willemsen, M.A.A.P., Oegema, R., Mitchell, W.G., Pierson, T.M., Andrews, M.V., Willing, M.C., Rodan, L.H., Barakat, T.S., van Slegtenhorst, M., Gavrilova, R.H., Martinelli, D., Gilboa, T., Tamim, A.M., Hashem, M.O., AlSayed, M.D., Abdulrahim, M.M., Al-Owain, M., Awaji, A., Mahmoud, A.A.H., Faqeih, E.A., Asmari, A.A., Algain, S.M., Jad, L.A., Aldhalaan, H.M., Helbig, I., Koolen, D.A., Riess, A., Kraegeloh-Mann, I., Bauer, P., Gulsuner, S., Stamberger, H., Ng, A.Y.J., Tang, S., Tohari, S., Keren, B., Schultz-Rogers, L.E., Klee, E.W., Barresi, S., Tartaglia, M., Mor-Shaked, H., Maddirevula, S., Begtrup, A., Telegrafi, A., Pfundt, R., Schüle, R., Ciruna, B., Bonnard, C., Pouladi, M.A., Stewart, J.C., Claridge-Chang, A., Lefeber, D.J., Alkuraya, F.S., Mathuru, A.S., Venkatesh, B., Barycki, J.J., Simpson, M.A., Jamuar, S.S., Schöls, L., Reversade, B. (2020) Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy. Nature communications. 11:595
- Wang, D., Zhang, Y., Li, J., Dahlgren, R.A., Wang, X., Huang, H., Wang, H. (2020) Risk assessment of cardiotoxicity to zebrafish (Danio rerio) by environmental exposure to triclosan and its derivatives. Environmental pollution (Barking, Essex : 1987). 265:114995
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Ortiz-Villanueva, E., Navarro-Martín, L., Jaumot, J., Benavente, F., Sanz-Nebot, V., Piña, B., Tauler, R. (2017) Metabolic disruption of zebrafish (Danio rerio) embryos by bisphenol A. An integrated metabolomic and transcriptomic approach. Environmental pollution (Barking, Essex : 1987). 231:22-36
- Superina, S., Borovina, A., and Ciruna, B. (2014) Analysis of maternal-zygotic ugdh mutants reveals divergent roles for HSPGs in vertebrate embryogenesis and provides new insight into the initiation of left-right asymmetry. Developmental Biology. 387(2):154-166
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