Gene
pklr
- ID
- ZDB-GENE-010907-1
- Name
- pyruvate kinase L/R
- Symbol
- pklr Nomenclature History
- Previous Names
-
- wu:fd15e01
- wu:fi37e08
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable pyruvate kinase activity. Acts upstream of or within liver development. Predicted to be active in cytoplasm. Is expressed in digestive system; female organism; heart; male organism; and muscle. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; congenital nonspherocytic hemolytic anemia 2; malaria; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nonspherocytic hemolytic anemia 2 | Alliance | Anemia, congenital, nonspherocytic hemolytic, 2, pyruvate kinase deficient | 266200 |
| [Adenosine triphosphate, elevated, of erythrocytes] | 102900 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Pyruvate kinase | Pyruvate kinase, active site | Pyruvate kinase, barrel | Pyruvate kinase, C-terminal | Pyruvate kinase, C-terminal domain superfamily | Pyruvate kinase, insert domain superfamily | Pyruvate kinase-like domain superfamily | Pyruvate kinase-like, insert domain superfamily | Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SXK3 | InterPro | 538 | |||||||||
| UniProtKB:A0A8M9NZ14 | InterPro | 527 | |||||||||
| UniProtKB:A0AB32T4X3 | InterPro | 469 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | EST | fd15e01 | ZFIN Curated Data | |
| Encodes | EST | fi37e08 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:66245 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174509 | ZFIN Curated Data |
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- Banerjee, K., Mandal, S., Nath, A., Chakraborty, S.B., Mitra, A., Gupta, S. (2025) Thyroxine (T3)-mediated regulation of early cardiac repair in a chemical-induced hypoxia/reoxygenation model of adult zebrafish (Danio rerio). Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 33:e13244e13244
- Li, S., Li, H., Bennewitz, K., Poschet, G., Buettner, M., Hausser, I., Szendroedi, J., Nawroth, P.P., Kroll, J. (2025) Combined loss of glyoxalase 1 and aldehyde dehydrogenase 3a1 amplifies dicarbonyl stress, impairs proteasome activity resulting in hyperglycemia and activated retinal angiogenesis. Metabolism: clinical and experimental. :156149156149
- Chen, J., Zhao, W., Cao, L., Martins, R.S.T., Canário, A.V.M. (2024) Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish. BMC Biology. 22:163163
- Du, Q., Shao, R., Wang, W., Zhang, H., Liao, X., Wang, Z., Yin, Z., Ai, Q., Mai, K., Tang, X., Wan, M. (2024) Vitamin D3 Regulates Energy Homeostasis under Short-Term Fasting Condition in Zebrafish (Danio Rerio). Nutrients. 16(9):
- Karampelias, C., Băloiu, B., Rathkolb, B., da Silva-Buttkus, P., Bachar-Wikström, E., Marschall, S., Fuchs, H., Gailus-Durner, V., Chu, L., Hrabě de Angelis, M., Andersson, O. (2024) Examining the liver-pancreas crosstalk reveals a role for the molybdenum cofactor in β-cell regeneration. Life science alliance. 7(11):
- Schmitner, N., Thumer, S., Regele, D., Mayer, E., Bergerweiss, I., Helker, C., Stainier, D.Y.R., Meyer, D., Kimmel, R.A. (2024) Conserved glucokinase regulation in zebrafish confirms therapeutic utility for pharmacologic modulation in diabetes. Communications biology. 7:15571557
- Wang, J.X., Zhang, Y.Y., Qian, Y.C., Qian, Y.F., Jin, A.H., Wang, M., Luo, Y., Qiao, F., Zhang, M.L., Chen, L.Q., Du, Z.Y. (2024) Inhibition of mitochondrial citrate shuttle alleviates metabolic syndromes induced by high-fat diet. American journal of physiology. Cell physiology. 327(3):C737-C749
- Xu, Y., Zhang, S., Bao, Y., Luan, J., Fu, Z., Sun, M., Zhao, X., Feng, X. (2024) Melatonin protects zebrafish pancreatic development and physiological rhythms from sodium propionate-induced disturbances via the hypothalamic-pituitary-thyroid axis. Journal of the science of food and agriculture. 104(12):7454-7463
- Zhu, X., Zhang, D., Wang, Y., Wang, C., Liu, X., Niu, Y. (2024) Study on the signaling pathways involved in the anti-hyperglycemic effect of raspberry ketone on zebrafish using integrative transcriptome and metabolome analyses. Food & function. 15(18):9457-9470
- Antomagesh, F., Jayakumar Rajeswari, J., Vijayan, M.M. (2023) Chronic cortisol elevation restricts glucose uptake but not insulin responsiveness in zebrafish skeletal muscle. General and comparative endocrinology. 336:114231
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