Gene
ache
- ID
- ZDB-GENE-010906-1
- Name
- acetylcholinesterase (Yt blood group)
- Symbol
- ache Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables acetylcholinesterase activity. Acts upstream of or within several processes, including acetylcholine catabolic process; cellular response to methanol; and nervous system development. Predicted to be located in extracellular region; membrane; and synapse. Predicted to be active in extracellular space and plasma membrane. Is expressed in several structures, including female organism; male organism; muscle; nervous system; and neural tube. Human ortholog(s) of this gene implicated in Alzheimer's disease; drug dependence (multiple); epilepsy; myasthenia gravis; and subacute delirium. Orthologous to human ACHE (acetylcholinesterase (Yt blood group)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 31 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu3 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 24 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb832 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| ihb833 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| sa31572 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40891 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sb55 | Allele with one point mutation | Unknown | Missense | ENU | |
| tf222a | Allele with one point mutation | Unknown | Missense | not specified | |
| tm205 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tm206 | unknown | Unknown | Unknown | ENU |
1 - 8 of 8
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ache | Zebrafish Nomenclature Committee | |
| CRISPR2-ache | Moreno-Campos et al., 2024 | |
| MO1-ache | N/A | (2) |
1 - 3 of 3
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| [Blood group, Yt system] | 112100 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR019826 | Carboxylesterase type B, active site |
| Conserved_site | IPR019819 | Carboxylesterase type B, conserved site |
| Domain | IPR002018 | Carboxylesterase, type B |
| Domain | IPR014788 | Acetylcholinesterase, tetramerisation domain |
| Family | IPR000997 | Cholinesterase |
1 - 5 of 7 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Acetylcholinesterase-related enzymes | Acetylcholinesterase, tetramerisation domain | Alpha/Beta hydrolase fold | Carboxylesterase, type B | Carboxylesterase type B, active site | Carboxylesterase type B, conserved site | Cholinesterase |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B3DKL4 | InterPro | 634 | |||||||
| UniProtKB:Q9DDE3 | InterPro | 634 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(Cca.Actb:YFP,5xUAS:ache) |
|
| 1 | (3) |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-153N19 | ZFIN Curated Data | |
| Contained in | BAC | CH211-196F2 | ZFIN Curated Data | |
| Encodes | EST | eu3 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:92550 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195318 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195325 | ZFIN Curated Data |
1 - 6 of 6
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131846 (1) | 4825 nt | ||
| Genomic | GenBank:BX470232 (1) | 194721 nt | ||
| Polypeptide | UniProtKB:B3DKL4 (1) | 634 aa |
- Gamba, B.F.G., Pickler, K.P., Lodetti, G., Farias, A.C.S., Teixeira, A.G., Bernardo, H.T., Dondossola, E.R., Cararo, J.H., Luchiari, A.C., Rosemberg, D.B., Rico, E.P. (2024) Embryonic alcohol exposure alters cholinergic neurotransmission and memory in adult zebrafish. Behavioural brain research. 474:115176
- Moreno-Campos, R., Singleton, E.W., Uribe, R.A. (2024) A targeted CRISPR-Cas9 mediated F0 screen identifies genes involved in establishment of the enteric nervous system. PLoS One. 19:e0303914e0303914
- Wang, H., Li, X., Li, J., Yu, F., Li, Q., Qin, M., Gui, L., Qian, Y., Huang, M. (2024) Long-term exposure to ionic liquid [C8mim]Br induces the potential risk of anxiety and memory deterioration through disturbing neurotransmitter systems. Neurotoxicology. 104:66-74
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Araujo-Silva, H., de Souza, A.M., Mamede, J.P.M., Batistuzzo de Medeiros, S.R., Luchiari, A.C. (2023) Individual differences in response to alcohol and nicotine in zebrafish: gene expression and behavior. Development, growth & differentiation. 65(8):434-445
- Karoglu-Eravsar, E.T., Tuz-Sasik, M.U., Karaduman, A., Keskus, A.G., Arslan-Ergul, A., Konu, O., Kafaligonul, H., Adams, M.M. (2023) Long-term Acetylcholinesterase Depletion Alters the Levels of Key Synaptic Proteins while Maintaining Neuronal Markers in the Aging Zebrafish (Danio rerio) Brain. Gerontology. 69(12):1424-1436
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Ivantsova, E., Wengrovitz, A.S., Souders, C.L., Martyniuk, C.J. (2022) Developmental and behavioral toxicity assessment of glyphosate and its main metabolite aminomethylphosphonic acid (AMPA) in zebrafish embryos/larvae. Environmental Toxicology and Pharmacology. 93:103873
- Kantha, P., Liu, S.T., Horng, J.L., Lin, L.Y. (2022) Acute exposure to polystyrene nanoplastics impairs skin cells and ion regulation in zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands). 248:106203
- Shen, W.Y., Fu, X.H., Cai, J., Li, W.C., Fan, B.Y., Pang, Y.L., Zhao, C.X., Abula, M., Kong, X.H., Yao, X., Feng, S.Q. (2022) Identification of key genes involved in recovery from spinal cord injury in adult zebrafish. Neural regeneration research. 17:1334-1342
1 - 10 of 113
Show