Gene
angpt2b
- ID
- ZDB-GENE-010817-2
- Name
- angiopoietin 2b
- Symbol
- angpt2b Nomenclature History
- Previous Names
-
- ang2 (1)
- angpt2
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Acts upstream of or within blood vessel development. Predicted to be active in extracellular matrix and extracellular space. Is expressed in head mesenchyme; heart; lymphatic system; pronephric glomerulus; and vascular endothelium. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human ANGPT2 (angiopoietin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu404 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la013481Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa43320 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-angpt2b | N/A | (3) |
| MO2-angpt2b | N/A | (2) |
| MO3-angpt2b | N/A | Li et al., 2014 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Lymphatic malformation 10 | 619369 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020837 | Fibrinogen, conserved site |
| Domain | IPR002181 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain |
| Family | IPR050373 | Fibrinogen C-terminal domain-containing protein |
| Homologous_superfamily | IPR014716 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 |
| Homologous_superfamily | IPR036056 | Fibrinogen-like, C-terminal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 | Fibrinogen, conserved site | Fibrinogen C-terminal domain-containing protein | Fibrinogen-like, C-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q90Z18 | InterPro | 489 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
angpt2b-201
(1)
|
Ensembl | 1,790 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-206O8 | ZFIN Curated Data | |
| Encodes | EST | eu404 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:193798 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131814 (1) | 1509 nt | ||
| Genomic | GenBank:BX537287 (2) | 195505 nt | ||
| Polypeptide | UniProtKB:Q90Z18 (1) | 489 aa |
- Chen, Y.C., Martins, T.A., Marchica, V., Panula, P. (2024) Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development. Frontiers in Cellular Neuroscience. 17:12897941289794
- He, Y., Kam, H., Wu, X., Chen, Q., Lee, S.M.Y. (2023) Dual effect of aucubin on promoting VEGFR2 mediated angiogenesis and reducing RANKL-induced bone resorption. Chinese Medicine. 18:108108
- Lazzaroni, F., Meessen, J.M.T.A., Sun, Y., Lanfranconi, S., Scola, E., D'Alessandris, Q.G., Tassi, L., Carriero, M.R., Castori, M., Marino, S., Blanda, A., Nicolis, E.B., Novelli, D., Calabrese, R., Agnelli, N.M., Bottazzi, B., Leone, R., Mazzola, S., Besana, S., Catozzi, C., Nezi, L., Lampugnani, M.G., Malinverno, M., Grdseloff, N., Rödel, C.J., Rezai Jahromi, B., Bolli, N., Passamonti, F., Magnusson, P.U., Abdelilah-Seyfried, S., Dejana, E., Latini, R. (2023) Circulating biomarkers in familial cerebral cavernous malformation. EBioMedicine. 99:104914104914
- Ribeiro, A., Rebocho da Costa, M., de Sena-Tomás, C., Rodrigues, E.C., Quitéria, R., Maçarico, T., Rosa Santos, S.C., Saúde, L. (2023) Development and repair of blood vessels in the zebrafish spinal cord. Open Biology. 13:230103230103
- Matrone, G., Jung, S.Y., Choi, J.M., Jain, A., Leung, H.E., Rajapakshe, K., Coarfa, C., Rodor, J., Denvir, M.A., Baker, A.H., Cooke, J.P. (2021) Nuclear S-nitrosylation impacts tissue regeneration in zebrafish. Nature communications. 12:6282
- Gong, G., Kam, H., Tse, Y.C., Giesy, J.P., Seto, S.W., Lee, S.M. (2020) Forchlorfenuron (CPPU) causes disorganization of the cytoskeleton and dysfunction of human umbilical vein endothelial cells, and abnormal vascular development in zebrafish embryos. Environmental pollution (Barking, Essex : 1987). 271:115791
- Liu, Y.Y., Wu, J.Q., Fan, R.Y., He, Z.H., Li, C.Y., He, M.F. (2020) Isoliquiritin promote angiogenesis by recruiting macrophages to improve the healing of zebrafish wounds. Fish & shellfish immunology. 100:238-245
- Mi, X., Li, Z., Yan, J., Li, Y., Zheng, J., Zhaung, Z., Yang, W., Gong, L., Shi, J. (2020) Activation of HIF-1 signaling ameliorates liver steatosis in zebrafish atp7b deficiency (Wilson's disease) models. Biochimica et biophysica acta. Molecular basis of disease. 1866(10):165842
- Hu, J., Lin, S., Huang, J.J., Cheung, P.C.K. (2018) Mechanistic study of the in vitro and in vivo inhibitory effects of protocatechuic acid and syringic acid on VEGF-induced angiogenesis. Journal of Agricultural and Food Chemistry. 66(26):6742-6751
- Zhang, H.Z., Li, C.Y., Wu, J.Q., Wang, R.X., Wei, P., Liu, M.H., He, M.F. (2018) Anti-angiogenic activity of para-coumaric acid methyl ester on HUVECs in vitro and zebrafish in vivo. Phytomedicine : international journal of phytotherapy and phytopharmacology. 48:10-20
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