Gene
angpt1
- ID
- ZDB-GENE-010817-1
- Name
- angiopoietin 1
- Symbol
- angpt1 Nomenclature History
- Previous Names
-
- ang1 (1)
- wu:fc76g06
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable receptor tyrosine kinase binding activity. Acts upstream of or within blood vessel development and brain development. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including brain; cardiovascular system; hypochord; medial longitudinal fasciculus; and ventral mesenchyme. Human ortholog(s) of this gene implicated in alcohol dependence; brain ischemia; diabetic retinopathy; hereditary angioedema; and hypertension. Orthologous to human ANGPT1 (angiopoietin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028073Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa14264 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30714 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43349 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 4 of 4
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-angpt1 | N/A | (2) |
| MO2-angpt1 | N/A | Lamont et al., 2010 |
| MO3-angpt1 | N/A | Li et al., 2014 |
1 - 3 of 3
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Angioedema, hereditary, 5 | 619361 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020837 | Fibrinogen, conserved site |
| Domain | IPR002181 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain |
| Family | IPR037579 | Fibrinogen/angiopoietin-like |
| Homologous_superfamily | IPR014716 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 |
| Homologous_superfamily | IPR036056 | Fibrinogen-like, C-terminal |
1 - 5 of 5
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 | Fibrinogen/angiopoietin-like | Fibrinogen, conserved site | Fibrinogen-like, C-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q90Z19 | InterPro | 513 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
angpt1-201
(1)
|
Ensembl | 2,164 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-338A11 | ZFIN Curated Data | |
| Contained in | BAC | CH211-121H11 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-163O15 | ZFIN Curated Data | |
| Encodes | EST | fc76g06 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195033 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195051 | ZFIN Curated Data |
1 - 6 of 6
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131813 (1) | 1595 nt | ||
| Genomic | GenBank:AL953858 (2) | 145746 nt | ||
| Polypeptide | UniProtKB:Q90Z19 (1) | 513 aa |
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Chen, Y.C., Martins, T.A., Marchica, V., Panula, P. (2024) Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development. Frontiers in Cellular Neuroscience. 17:12897941289794
- Pham, V.C., Rödel, C.J., Valentino, M., Malinverno, M., Paolini, A., Münch, J., Pasquier, C., Onyeogaziri, F.C., Lazovic, B., Girard, R., Koskimäki, J., Hußmann, M., Keith, B., Jachimowicz, D., Kohl, F., Hagelkruys, A., Penninger, J.M., Schulte-Merker, S., Awad, I.A., Hicks, R., Magnusson, P.U., Faurobert, E., Pagani, M., Abdelilah-Seyfried, S. (2024) Epigenetic regulation by polycomb repressive complex 1 promotes cerebral cavernous malformations. EMBO Molecular Medicine. 16(11):2827-2855
- He, Y., Kam, H., Wu, X., Chen, Q., Lee, S.M.Y. (2023) Dual effect of aucubin on promoting VEGFR2 mediated angiogenesis and reducing RANKL-induced bone resorption. Chinese Medicine. 18:108108
- Kondo, M., Kimura, K., Kobayashi-Sun, J., Yamamori, S., Taniguchi, M., Traver, D., Kobayashi, I. (2023) The sinusoidal hematopoietic niche is formed by Jam1a via Notch signaling in the zebrafish kidney. iScience. 26:106508106508
- Ribeiro, A., Rebocho da Costa, M., de Sena-Tomás, C., Rodrigues, E.C., Quitéria, R., Maçarico, T., Rosa Santos, S.C., Saúde, L. (2023) Development and repair of blood vessels in the zebrafish spinal cord. Open Biology. 13:230103230103
- Zhang, R., Ma, Z., Wang, J., Fan, C. (2023) HIF signaling overactivation inhibits lateral line neuromast development through Wnt in zebrafish. Gene. 898:148077
- Wang, W., Li, H., Huang, M., Wang, X., Li, W., Qian, X., Jing, L. (2022) Hoxa9/meis1-transgenic zebrafish develops acute myeloid leukaemia-like disease with rapid onset and high penetrance. Open Biology. 12:220172
- Balkrishna, A., Solleti, S.K., Verma, S., Varshney, A. (2020) Validation of a Novel Zebrafish Model of Dengue Virus (DENV-3) Pathology Using the Pentaherbal Medicine Denguenil Vati. Biomolecules. 10(7):
- Gong, G., Kam, H., Tse, Y.C., Giesy, J.P., Seto, S.W., Lee, S.M. (2020) Forchlorfenuron (CPPU) causes disorganization of the cytoskeleton and dysfunction of human umbilical vein endothelial cells, and abnormal vascular development in zebrafish embryos. Environmental pollution (Barking, Essex : 1987). 271:115791
1 - 10 of 51
Show