Gene

angpt1

ID
ZDB-GENE-010817-1
Name
angiopoietin 1
Symbol
angpt1 Nomenclature History
Previous Names
  • ang1 (1)
  • wu:fc76g06
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to enable receptor tyrosine kinase binding activity. Acts upstream of or within blood vessel development and brain development. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including brain; cardiovascular system; hypochord; medial longitudinal fasciculus; and ventral mesenchyme. Human ortholog(s) of this gene implicated in alcohol dependence; brain ischemia; diabetic retinopathy; hereditary angioedema; and hypertension. Orthologous to human ANGPT1 (angiopoietin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 15 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
1 - 4 of 4
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-angpt1N/A (2)
MO2-angpt1N/ALamont et al., 2010
MO3-angpt1N/ALi et al., 2014
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Human Disease
Associated With angpt1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Angioedema, hereditary, 5 619361
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Associated With angpt1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020837 Fibrinogen, conserved site
Domain IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Family IPR037579 Fibrinogen/angiopoietin-like
Homologous_superfamily IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Homologous_superfamily IPR036056 Fibrinogen-like, C-terminal
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Domain Details Per Protein
Protein Additional Resources Length Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 Fibrinogen/angiopoietin-like Fibrinogen, conserved site Fibrinogen-like, C-terminal
UniProtKB:Q90Z19 InterPro 513
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 19
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA angpt1-201 (1) Ensembl 2,164 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanANGPT18
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseAngpt115
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
1 - 10 of 51
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