Gene
f7
- ID
- ZDB-GENE-010814-1
- Name
- coagulation factor VII
- Symbol
- f7 Nomenclature History
- Previous Names
-
- wu:fb59f04
- zgc:109870
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase activity. Acts upstream of or within blood coagulation, fibrin clot formation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in blood plasma; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebral infarction; diabetes mellitus (multiple); factor VII deficiency; and obesity. Orthologous to human F7 (coagulation factor VII).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109870 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Khandekar et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zko2a | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-f7 | (2) | |
| MO1-f7 | N/A | Gregory et al., 2002 |
| MO2-f7 | N/A | Khandekar et al., 2014 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| factor VII deficiency | Alliance | Factor VII deficiency | 227500 |
| {Myocardial infarction, decreased susceptibility to} | 608446 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018114 | Serine proteases, trypsin family, histidine active site |
| Active_site | IPR033116 | Serine proteases, trypsin family, serine active site |
| Domain | IPR000294 | Gamma-carboxyglutamic acid-rich (GLA) domain |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001254 | Serine proteases, trypsin domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Coagulation factor-like, Gla domain superfamily | EGF-like calcium-binding domain | EGF-like domain | Gamma-carboxyglutamic acid-rich (GLA) domain | Gamma-carboxyglutamic acid-rich (GLA) domain superfamily | Peptidase S1A, chymotrypsin family | Peptidase S1A, coagulation factor VII/IX/X/C/Z | Peptidase S1 family, coagulation factors | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Serine proteases, trypsin domain | Serine proteases, trypsin family, histidine active site | Serine proteases, trypsin family, serine active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q504H3 | InterPro | 433 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | ZFOS-1962A1 | ZFIN Curated Data | |
| Encodes | EST | fb59f04 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:109870 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193057 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131819 (1) | 1828 nt | ||
| Genomic | GenBank:FP017167 (1) | 39043 nt | ||
| Polypeptide | UniProtKB:Q504H3 (1) | 433 aa |
- Deebani, A., Mary, J., Dhinoja, S., Al Qaryoute, A., Fallatah, W., Jagadeeswaran, P. (2025) Knockdown of zebrafish tmem242 enhances the production of ROS that signals to increase f9a expression resulting in DIC-like condition. Scientific Reports. 15:30583058
- Xie, C., Zheng, N., Li, M., Zhang, Z., Huang, D., Xiao, M., Chen, D., He, C., Zuo, Z., Chen, X. (2024) Comparative Analysis of Therapeutic Efficacy and Adverse Reactions among Various Thrombolytic Agents. Toxics. 12(7):
- Zhang, H., Sun, C., Xia, Q., Li, P., Liu, K., Zhang, Y. (2024) Brevianamide F Exerts Antithrombotic Effects by Modulating the MAPK Signaling Pathway and Coagulation Cascade. Marine drugs. 22(10):
- Ma, X., Guo, R., Xu, H., Ma, Y., Zhang, R., Liu, X., Zhang, J., Han, Y. (2023) Developmental adcyap1b loss leads to hemorrhage, disrupted hemostasis, and a blood coagulation cascade in zebrafish. Journal of thrombosis and haemostasis : JTH. 22(4):951-964
- Wang, Y., Wu, H., Sheng, H., Wang, Y., Li, X., Wang, Y., Zhao, L. (2022) Discovery of anti-stroke active substances in Guhong injection based on multi-phenotypic screening of zebrafish. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 155:113744
- Zhang, Y., Ma, C., He, L., Liao, L., Guo, C., Wang, C., Gong, L., Zhou, H., Fu, K., Peng, C., Li, Y. (2022) Tetramethylpyrazine Protects Endothelial Injury and Antithrombosis via Antioxidant and Antiapoptosis in HUVECs and Zebrafish. Oxidative medicine and cellular longevity. 2022:2232365
- Li, J., Liu, H., Yang, Z., Yu, Q., Zhao, L., Wang, Y. (2021) Synergistic Effects of Cryptotanshinone and Senkyunolide I in Guanxinning Tablet Against Endogenous Thrombus Formation in Zebrafish. Frontiers in pharmacology. 11:622787
- Khandekar, G., Iyer, N., Jagadeeswaran, P. (2020) Prostasin and hepatocyte growth factor B in factor VIIa generation: Serine protease knockdowns in zebrafish. Research and practice in thrombosis and haemostasis. 4:1150-1157
- Raman, R., Ryon, M., Jagadeeswaran, P. (2020) RNaseH-mediated simultaneous piggyback knockdown of multiple genes in adult zebrafish. Scientific Reports. 10:20187
- Sheng, J., Meng, Q., Yang, Z., Guan, J., Zhao, Y., Zhang, J., Wang, Y., Zhao, L., Wang, Y. (2020) Identification of cryptotanshinone from Tongmai to inhibit thrombosis in zebrafish via regulating oxidative stress and coagulation cascade. Phytomedicine : international journal of phytotherapy and phytopharmacology. 76:153263
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