Gene
copb2
- ID
- ZDB-GENE-010724-7
- Name
- COPI coat complex subunit beta 2
- Symbol
- copb2 Nomenclature History
- Previous Names
-
- dop
- dopey
- sb:cb121
- wu:fb30f06
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable structural molecule activity. Acts upstream of or within several processes, including Golgi localization; endoplasmic reticulum localization; and notochord development. Predicted to be located in COPI-coated vesicle membrane and Golgi membrane. Predicted to be part of COPI vesicle coat. Is expressed in several structures, including axial mesoderm; cardiovascular system; digestive system; fin; and nervous system. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 19. Orthologous to human COPB2 (COPI coat complex subunit beta 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb121 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b1327 | Allele with one delins | Exon 2 | Unknown | CRISPR | |
| la023673Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| m341 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| m475 | unknown | Unknown | Unknown | ENU | |
| sa39897 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tm18a | unknown | Unknown | Unknown | ENU | |
| tr222b | unknown | Unknown | Unknown | ENU | |
| tz226 | unknown | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-copb2 | Marom et al., 2021 | |
| MO1-copb2 | N/A | Coutinho et al., 2004 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary autosomal recessive microcephaly 19 | Alliance | ?Microcephaly 19, primary, autosomal recessive | 617800 |
| Osteoporosis, childhood- or juvenile-onset, with developmental delay | 619884 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006692 | COPA/B second beta-propeller domain |
| Domain | IPR056176 | COPA/B, TPR domain |
| Family | IPR016453 | Coatomer beta' subunit (COPB2) |
| Family | IPR050844 | Coatomer complex subunit |
| Homologous_superfamily | IPR011044 | Quinoprotein amine dehydrogenase, beta chain-like |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Coatomer beta' subunit (COPB2) | Coatomer complex subunit | COPA/B second beta-propeller domain | COPA/B, TPR domain | G-protein beta WD-40 repeat | Quinoprotein amine dehydrogenase, beta chain-like | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6JWU7 | InterPro | 934 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-119O8 | ZFIN Curated Data | |
| Contains | SNP | rs3727648 | ZFIN Curated Data | |
| Contains | SNP | rs3727649 | ZFIN Curated Data | |
| Contains | SNP | rs3727650 | ZFIN Curated Data | |
| Encodes | EST | cb121 | ZFIN Curated Data | |
| Encodes | EST | fb30f06 | Rajarao et al., 2001 | |
| Encodes | EST | wz178 | ||
| Encodes | cDNA | MGC:175021 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194073 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001001940 (1) | 3170 nt | ||
| Genomic | GenBank:AL953896 (1) | 158018 nt | ||
| Polypeptide | UniProtKB:Q6JWU7 (1) | 934 aa |
- Yang, Y., Zhang, X., Zhao, Q., Zhang, J., Lou, X. (2024) Compromised COPII vesicle trafficking leads to glycogenic hepatopathy in zebrafish. Disease models & mechanisms. 17(9):
- Marom, R., Burrage, L.C., Venditti, R., Clément, A., Blanco-Sánchez, B., Jain, M., Scott, D.A., Rosenfeld, J.A., Sutton, V.R., Shinawi, M., Mirzaa, G., DeVile, C., Roberts, R., Calder, A.D., Allgrove, J., Grafe, I., Lanza, D.G., Li, X., Joeng, K.S., Lee, Y.C., Song, I.W., Sliepka, J.M., Batkovskyte, D., Washington, M., Dawson, B.C., Jin, Z., Jiang, M.M., Chen, S., Chen, Y., Tran, A.A., Emrick, L.T., Murdock, D.R., Hanchard, N.A., Zapata, G.E., Mehta, N.R., Weis, M.A., Scott, A.A., Tremp, B.A., Phillips, J.B., Wegner, J., Taylor-Miller, T., Gibbs, R.A., Muzny, D.M., Jhangiani, S.N., Hicks, J., Stottmann, R.W., Dickinson, M.E., Seavitt, J.R., Heaney, J.D., Eyre, D.R., Undiagnosed Diseases Network, Westerfield, M., De Matteis, M.A., Lee, B. (2021) COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay. American journal of human genetics. 108(9):1710-1724
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Yang, Y.J., Wang, Y., Li, Z., Zhou, L., Gui, J.F. (2017) Sequential, Divergent, and Cooperative Requirements of Foxl2a and Foxl2b in Ovary Development and Maintenance of Zebrafish.. Genetics. 205(4):1551-1572
- Lim, A., Moussavi Nik, S.H., Ebrahimie, E., Lardelli, M. (2015) Analysis of nicastrin gene phylogeny and expression in zebrafish. Development genes and evolution. 225(3):171-8
- Herrero-Turrión, M.J., Rodríguez-Martín, I., López-Bellido, R., Rodríguez, R.E. (2014) Whole-genome expression profile in zebrafish embryos after chronic exposure to morphine: identification of new genes associated with neuronal function and mu opioid receptor expression. BMC Genomics. 15:874
- Crespo, B., Lan-Chow-Wing, O., Rocha, A., Zanuy, S., Gómez, A. (2013) foxl2 and foxl3 are two ancient paralogs that remain fully functional in teleosts. General and comparative endocrinology. 194:81-93
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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