Gene
cry1a
- ID
- ZDB-GENE-010426-2
- Name
- cryptochrome circadian regulator 1a
- Symbol
- cry1a Nomenclature History
- Previous Names
-
- cry1a
- cry1aa
- zcry1a (1)
- zgc:153885
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Enables transcription corepressor activity. Acts upstream of or within several processes, including entrainment of circadian clock; negative regulation of DNA-templated transcription; and response to hydrogen peroxide. Located in nucleus. Part of transcription regulator complex. Is expressed in brain; eye; integument; and kidney. Human ortholog(s) of this gene implicated in delayed sleep phase syndrome. Orthologous to human CRY1 (cryptochrome circadian regulator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-cry1a | N/A | Kayser et al., 2022 |
| MO2-cry1a | N/A | Kayser et al., 2022 |
| TALEN1-cry1a | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Delayed sleep phase disorder, susceptibility to} | 614163 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005101 | Cryptochrome/DNA photolyase, FAD-binding domain |
| Domain | IPR006050 | DNA photolyase, N-terminal |
| Family | IPR002081 | Cryptochrome/DNA photolyase class 1 |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
| Homologous_superfamily | IPR036134 | Cryptochrome/DNA photolyase, FAD-binding domain-like superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cryptochrome/DNA photolyase class 1 | Cryptochrome/DNA photolyase, FAD-binding domain | Cryptochrome/DNA photolyase, FAD-binding domain-like superfamily | Cryptochrome/photolyase, N-terminal domain superfamily | DNA photolyase, N-terminal | Rossmann-like alpha/beta/alpha sandwich fold |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A4QN37 | InterPro | 619 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cry1aa-201
(1)
|
Ensembl | 1,984 nt | ||
| mRNA |
cry1aa-202
(1)
|
Ensembl | 3,301 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-222F8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153885 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:161968 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194757 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077297 (1) | 3361 nt | ||
| Genomic | GenBank:BX005210 (2) | 207949 nt | ||
| Polypeptide | UniProtKB:A4QN37 (1) | 619 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Cao, M., Xu, T., Song, Y., Wei, S., Wang, H., Guo, X., Yin, D. (2024) Brominated Flame Retardant HBCD and Artificial Light at Night Synergically Caused Visual Disorder and Sleep Difficulty in Zebrafish Larvae. Environmental science & technology. 58(39):17247-17258
- Chaigne, C., Sapède, D., Cousin, X., Sanchou, L., Blader, P., Cau, E. (2024) Contribution of the eye and of opn4xa function to circadian photoentrainment in the diurnal zebrafish. PLoS Genetics. 20:e1011172e1011172
- Chen, M., Ouyang, Y., Yang, Y., Liu, Z., Zhao, M. (2024) Impact of sleep problems on the cardiometabolic risks: an integrated epidemiological and metabolomics study. Diabetology & metabolic syndrome. 16:267267
- Ding, H., Chen, X.C., Wan, L., Zhang, Y.Y., Rui, X.H., He, T., Liu, J., Shang, Z.B. (2024) Klebsiella pneumoniae alters zebrafish circadian rhythm via inflammatory pathways and is dependent on light cues. Heliyon. 10:e30829e30829
- Godino-Gimeno, A., Leal, E., Chivite, M., Tormos, E., Rotllant, J., Vallone, D., Foulkes, N.S., Míguez, J.M., Cerdá-Reverter, J.M. (2024) Role of melanocortin system in the locomotor activity rhythms and melatonin secretion as revealed by agouti-signalling protein (asip1) overexpression in zebrafish. Journal of pineal research. 76:e12939e12939
- Liu, T., He, W., Zhong, Z., Lu, C., Wu, L., Wang, Z., Smith, W.K., Shi, Q., Long, Q., Wang, H. (2024) The circadian clock orchestrates spermatogonial differentiation and fertilization by regulating retinoic acid signaling in vertebrates. National science review. 12:nwae456nwae456
- Morales Fénero, C., Sacksteder, R.E., Diamos, A.G., Kimmey, J.M. (2024) Heat-inactivated Streptococcus pneumoniae augments circadian clock gene expression in zebrafish cells. Scientific Reports. 14:2780527805
- Aranda-Martínez, P., Fernández-Martínez, J., Ramírez-Casas, Y., Rodríguez-Santana, C., Rusanova, I., Escames, G., Acuña-Castroviejo, D. (2023) Chronodisruption and Loss of Melatonin Rhythm, Associated with Alterations in Daily Motor Activity and Mitochondrial Dynamics in Parkinsonian Zebrafish, Are Corrected by Melatonin Treatment. Antioxidants (Basel, Switzerland). 12(4):
- Cao, M., Xu, T., Zhang, H., Wei, S., Wang, H., Song, Y., Guo, X., Chen, D., Yin, D. (2023) BDE-47 Causes Depression-like Effects in Zebrafish Larvae via a Non-Image-Forming Visual Mechanism. Environmental science & technology. 57(26):9592-9602
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