Gene

cry1a

ID

ZDB-GENE-010426-2

Name

cryptochrome circadian regulator 1a

Symbol

cry1a Nomenclature History

Previous Names

cry1a
cry1aa
zcry1a (1)
zgc:153885

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Enables transcription corepressor activity. Acts upstream of or within several processes, including entrainment of circadian clock; negative regulation of DNA-templated transcription; and response to hydrogen peroxide. Located in nucleus. Part of transcription regulator complex. Is expressed in brain; eye; integument; and kidney. Human ortholog(s) of this gene implicated in delayed sleep phase syndrome. Orthologous to human CRY1 (cryptochrome circadian regulator 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

27 figures from 20 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cry1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Delayed sleep phase disorder, susceptibility to}	614163

Associated With cry1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005101	Cryptochrome/DNA photolyase, FAD-binding domain
Domain	IPR006050	DNA photolyase, N-terminal
Family	IPR002081	Cryptochrome/DNA photolyase class 1
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily	IPR036134	Cryptochrome/DNA photolyase, FAD-binding domain-like superfamily
Homologous_superfamily	IPR036155	Cryptochrome/photolyase, N-terminal domain superfamily