Gene
six2a
- ID
- ZDB-GENE-010412-1
- Name
- SIX homeobox 2a
- Symbol
- six2a Nomenclature History
- Previous Names
-
- six2.1
- wu:fj04e08
- zgc:91945
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within pronephros development. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including head mesenchyme; immature eye; intermediate mesoderm; nervous system; and pronephric tubule. Human ortholog(s) of this gene implicated in renal Wilms' tumor. Orthologous to human SIX2 (SIX homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91945 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Weber et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein SIX1, N-terminal SD domain | Homeodomain | KN homeodomain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q98TH1 | InterPro | 288 |
Interactions and Pathways
No data available
Plasmids
No data available