Gene
cldna
- ID
- ZDB-GENE-010328-1
- Name
- claudin a
- Symbol
- cldna Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable structural molecule activity. Predicted to be involved in bicellular tight junction assembly and cell adhesion. Predicted to be located in anchoring junction and membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in several structures, including gonad; nervous system; otic epithelium; otic vesicle; and spleen. Human ortholog(s) of this gene implicated in ovarian cancer and pancreatic cancer. Orthologous to human CLDN4 (claudin 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la019278Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Claudin | PMP-22/EMP/MP20/Claudin |
---|---|---|---|---|
UniProtKB:A0A8M1P6R7 | InterPro | 206 | ||
UniProtKB:Q90XS1 | InterPro | 206 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-235M3 | ZFIN Curated Data | |
Encodes | EST | fb99d09 | ZFIN Curated Data | |
Encodes | cDNA | MGC:77747 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131762 (1) | 1882 nt | ||
Genomic | GenBank:CR382327 (1) | 151282 nt | ||
Polypeptide | UniProtKB:A0A8M1P6R7 (1) | 206 aa |
No data available
- Rostam, N., Goloborodko, A., Riemer, S., Hertel, A., Riedel, D., Vorbrüggen, G., Dosch, R. (2022) The germ plasm is anchored at the cleavage furrows through interaction with tight junctions in the early zebrafish embryo. Development (Cambridge, England). 149(15)
- Phatak, M., Kulkarni, S., Miles, L.B., Anjum, N., Dworkin, S., Sonawane, M. (2021) Grhl3 promotes retention of epidermal cells under endocytic stress to maintain epidermal architecture in zebrafish. PLoS Genetics. 17:e1009823
- Conant, G.C. (2020) The lasting after-effects of an ancient polyploidy on the genomes of teleosts. PLoS One. 15:e0231356
- Hou, Y., Lee, H.J., Chen, Y., Ge, J., Osman, F.O.I., McAdow, A.R., Mokalled, M.H., Johnson, S.L., Zhao, G., Wang, T. (2020) Cellular diversity of the regenerating caudal fin. Science advances. 6:eaba2084
- Kim, S.S., Lee, J.A., Yeo, M.K. (2019) Reduction in Toxicity of Nano-Ag-Polyvinyl-pyrrolidone Using Hydra Proteins and Peptides during Zebrafish Embryogenesis. Nanomaterials (Basel, Switzerland). 9(9)
- Mathiyalagan, N., Miles, L.B., Anderson, P.J., Wilanowski, T., Grills, B.L., McDonald, S.J., Keightley, M.C., Charzynska, A., Dabrowski, M., Dworkin, S. (2019) Meta-Analysis of Grainyhead-Like Dependent Transcriptional Networks: A Roadmap for Identifying Novel Conserved Genetic Pathways. Genes. 10(11)
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Tobia, C., Chiodelli, P., Barbieri, A., Buraschi, S., Ferrari, E., Mitola, S., Borsani, G., Guerra, J., Presta, M. (2019) Atypical Chemokine Receptor 3 Generates Guidance Cues for CXCL12-Mediated Endothelial Cell Migration. Frontiers in immunology. 10:1092
- Gou, Y., Guo, J., Maulding, K., Riley, B.B. (2018) sox2 and sox3 cooperate to regulate otic/epibranchial placode induction in zebrafish. Developmental Biology. 435(1):84-95
- Li, X., Song, G., Zhao, Y., Zhao, F., Liu, C., Liu, D., Li, Q., Cui, Z. (2017) Claudin7b is required for the formation and function of inner ear in zebrafish. Journal of Cellular Physiology. 233(4):3195-3206
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