Gene
cdk1
- ID
- ZDB-GENE-010320-1
- Name
- cyclin dependent kinase 1
- Symbol
- cdk1 Nomenclature History
- Previous Names
-
- cdc2
- wu:fc30e01
- zgc:92032
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within neural retina development; regulation of mitotic cell cycle, embryonic; and spermatogenesis. Predicted to be located in centrosome and cytoplasm. Predicted to be active in nucleus. Is expressed in ciliary marginal zone and eye. Human ortholog(s) of this gene implicated in breast cancer; cervical cancer; and urinary bladder cancer. Orthologous to human CDK1 (cyclin dependent kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR050108 | Cyclin-dependent kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cyclin-dependent kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T3L7 | InterPro | 302 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-239N21 | ZFIN Curated Data | |
| Encodes | EST | fc30e01 | ||
| Encodes | cDNA | MGC:92032 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212564 (1) | 1390 nt | ||
| Genomic | GenBank:CU861473 (2) | 88180 nt | ||
| Polypeptide | UniProtKB:Q7T3L7 (1) | 302 aa |
- Guo, D., Xiong, H., Yang, Z., Zhang, R., Shi, P., Yao, Y., Liu, M., Xu, C., Wang, Q.K. (2024) Lysosomal membrane protein TMEM106B modulates hematopoietic stem and progenitor cell proliferation and differentiation by regulating LAMP2A stability. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 38:e23870e23870
- Han, Y., Sun, K., Yu, S., Qin, Y., Zhang, Z., Luo, J., Hu, H., Dai, L., Cui, M., Jiang, C., Liu, F., Huang, Y., Gao, P., Chen, X., Xin, T., Ren, X., Wu, X., Song, J., Wang, Q., Tang, Z., Chen, J., Zhang, H., Zhang, X., Liu, M., Luo, D. (2024) A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells. The EMBO journal. 43(10):1990-2014
- Li, K., Fan, D., Zhou, J., Zhao, Z., Han, A., Song, Z., Tang, X., Hu, B. (2024) Deletion of Slc1a4 Suppresses Single Mauthner Cell Axon Regeneration In Vivo through Growth-Associated Protein 43. International Journal of Molecular Sciences. 25(20):
- Uju, C., Karimzadeh, K., Unniappan, S. (2024) Brain Derived Neurotrophic Factor Stimulates Hypothalamic and Gonadal Reproductive Hormones and Oocyte Maturation in Zebrafish. Reproduction (Cambridge, England). 169(1):
- Xiao, G., Li, X., Yang, H., Zhang, R., Huang, J., Tian, Y., Nie, M., Sun, X. (2024) mTOR mutation disrupts larval zebrafish tail fin regeneration via regulating proliferation of blastema cells and mitochondrial functions. Journal of orthopaedic surgery and research. 19:321321
- Zhang, S., Yang, J., Xu, J., Li, J., Xu, L., Jin, N., Li, X. (2024) Integrative mRNA and miRNA Expression Profiles from Developing Zebrafish Head Highlight Brain-Preference Genes and Regulatory Networks. Molecular neurobiology. :
- Zhang, Y., Li, R., Li, H., Huang, Y., Mei, Y., Zheng, Y., Guo, Y., Zhou, Z., Yong, Z., Zhao, Y., Dong, W., Gao, J., Cao, X. (2024) Morpho-histological and Transcriptome Analysis Reveal the Unreduced Sperm Formation Mechanism in cdk1-Depletion Zebrafish. Marine biotechnology (New York, N.Y.). 26(6):1206-1218
- Zhu, B., Zhang, Z., Pardeshi, L., Chen, Y., Ge, W. (2024) Role of Y box-binding protein 1 (Ybx1) in zebrafish folliculogenesis: Promoting follicle cell proliferation via suppression of p21 (cdkn1a). Development (Cambridge, England). 151(21):
- Zhu, M., Li, Y., Liu, D., Gong, Z. (2024) Partial Hepatectomy Promotes the Development of KRASG12V-Induced Hepatocellular Carcinoma in Zebrafish. Cancers. 16(10):
- Zhu, M., Li, Y., Shen, Q., Gong, Z., Liu, D. (2024) Sex disparity in zebrafish liver cell proliferation after partial hepatectomy is regulated by sex hormone receptors and the S100A1-YAP signaling cascade. Disease models & mechanisms. 17(10):
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