Gene
pard6gb
- ID
- ZDB-GENE-010319-35
- Name
- par-6 family cell polarity regulator gamma b
- Symbol
- pard6gb Nomenclature History
- Previous Names
-
- cb182 (1)
- id:ibd2873
- sb:cb182
- wu:fc33c12
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including apical protein localization; regulation of collateral sprouting in absence of injury; and tube morphogenesis. Located in several cellular components, including apical plasma membrane; cleavage furrow; and nucleus. Is expressed in several structures, including EVL; axis; central nervous system; immature eye; and pharyngeal arch. Orthologous to human PARD6G (par-6 family cell polarity regulator gamma).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb182 (8 images)
- eu699 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh266 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| la020695Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| pard6gb_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU | |
| s441 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa6558 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23529 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23530 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36844 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43287 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-pard6gb | N/A | (2) |
| MO2-pard6gb | N/A | Slanchev et al., 2011 |
| MO3-pard6gb | N/A | Schmidt et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Partitioning defective 6 homolog protein | Partitioning defective protein 6, PB1 domain | PB1 domain | PB1-like domain | PDZ domain | PDZ superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6TNS1 | InterPro | 434 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pard6gb-201
(1)
|
Ensembl | 3,213 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-202E17 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-286J2 | ZFIN Curated Data | |
| Encodes | EST | cb182 | ZFIN Curated Data | |
| Encodes | EST | eu699 | Thisse et al., 2005 | |
| Encodes | EST | fc33c12 | ZFIN Curated Data | |
| Encodes | EST | ibd2873 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212563 (1) | 3096 nt | ||
| Genomic | GenBank:BX842688 (1) | 254720 nt | ||
| Polypeptide | UniProtKB:Q6TNS1 (1) | 434 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | PARD6G | 18 | Amino acid sequence comparison (1) |
- Shi, B., Zhang, J., Heng, J., Gong, J., Zhang, T., Li, P., Sun, B.F., Yang, Y., Zhang, N., Zhao, Y.L., Wang, H.L., Liu, F., Zhang, Q.C., Yang, Y.G. (2020) RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function. Genome biology. 21:120
- Sharma, P., Saraswathy, V.M., Xiang, L., Fürthauer, M. (2019) Notch-mediated inhibition of neurogenesis is required for zebrafish spinal cord morphogenesis. Scientific Reports. 9:9958
- Guo, C., Zou, J., Wen, Y., Fang, W., Stolz, D.B., Sun, M., Wei, X. (2018) Apical Cell-Cell Adhesions Reconcile Symmetry and Asymmetry in Zebrafish Neurulation. iScience. 3:63-85
- Gebauer, J.M., Kobbe, B., Paulsson, M., Wagener, R. (2016) Structure, evolution and expression of collagen XXVIII: Lessons from the zebrafish. Matrix biology : journal of the International Society for Matrix Biology. 49:106-19
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Schmidt, J.T., Mariconda, L., Morillo, F., and Apraku, E. (2014) A Role for the polarity complex and PI3 kinase in branch formation within retinotectal arbors of zebrafish. Developmental Neurobiology. 74(6):591-601
- Ivanovitch, K., Cavodeassi, F., and Wilson, S.W. (2013) Precocious acquisition of neuroepithelial character in the eye field underlies the onset of eye morphogenesis. Developmental Cell. 27(3):293-305
- Kondrychyn, I., Teh, C., Sin, M., and Korzh, V. (2013) Stretching morphogenesis of the roof plate and formation of the central canal. PLoS One. 8(2):e56219
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Slanchev, K., Pütz, M., Schmitt, A., Kramer-Zucker, A., and Walz, G. (2011) Nephrocystin-4 is required for pronephric duct-dependent cloaca formation in zebrafish. Human molecular genetics. 20(16):3119-28
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